Publication Date:
2006-09-30
Description:
The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Galon, Jerome -- Costes, Anne -- Sanchez-Cabo, Fatima -- Kirilovsky, Amos -- Mlecnik, Bernhard -- Lagorce-Pages, Christine -- Tosolini, Marie -- Camus, Matthieu -- Berger, Anne -- Wind, Philippe -- Zinzindohoue, Franck -- Bruneval, Patrick -- Cugnenc, Paul-Henri -- Trajanoski, Zlatko -- Fridman, Wolf-Herman -- Pages, Franck -- New York, N.Y. -- Science. 2006 Sep 29;313(5795):1960-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉INSERM U 255, Paris, 75006 France; Universite Paris-Descartes Paris 5, Faculte de Medecine, Paris, 75006 France. jerome.galon@u255.bhdc.jussieu.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17008531" target="_blank"〉PubMed〈/a〉
Keywords:
Antigens, CD3/*analysis
;
Antigens, CD45/analysis
;
CD8-Positive T-Lymphocytes/immunology
;
Cohort Studies
;
Colorectal Neoplasms/genetics/*immunology/pathology
;
Disease Progression
;
Disease-Free Survival
;
Female
;
Gene Expression Profiling
;
Humans
;
Immunohistochemistry
;
Immunologic Memory
;
Lymphatic Metastasis
;
Lymphocyte Count
;
Lymphocytes, Tumor-Infiltrating/*immunology
;
Male
;
Neoplasm Invasiveness
;
Neoplasm Recurrence, Local/immunology/prevention & control
;
Neoplasm Staging
;
Oligonucleotide Array Sequence Analysis
;
Polymerase Chain Reaction
;
Prognosis
;
Survival Analysis
;
T-Lymphocyte Subsets/*immunology
;
Th1 Cells/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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