Publication Date:
1997-07-11
Description:
Platelet-derived growth factor (PDGF)-B-deficient mouse embryos were found to lack microvascular pericytes, which normally form part of the capillary wall, and they developed numerous capillary microaneurysms that ruptured at late gestation. Endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rbeta-positive pericyte progenitor cells. Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lindahl, P -- Johansson, B R -- Leveen, P -- Betsholtz, C -- New York, N.Y. -- Science. 1997 Jul 11;277(5323):242-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medical Biochemistry, University of Goteborg, Medicinaregatan 9A, S-413 90 Goteborg, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9211853" target="_blank"〉PubMed〈/a〉
Keywords:
Aneurysm/*etiology
;
Animals
;
Brain/blood supply
;
Capillaries/*cytology/embryology/metabolism
;
Cell Movement
;
Endothelium, Vascular/cytology/metabolism
;
Hemorrhage/etiology
;
Mice
;
Mice, Inbred C57BL
;
Mutation
;
Neovascularization, Physiologic
;
Platelet-Derived Growth Factor/deficiency/genetics/*physiology
;
Proto-Oncogene Proteins/deficiency/genetics/*physiology
;
Proto-Oncogene Proteins c-sis
;
Receptor Protein-Tyrosine Kinases/metabolism
;
Receptor, Platelet-Derived Growth Factor beta
;
Receptor, TIE-2
;
Receptors, Platelet-Derived Growth Factor/metabolism
;
Signal Transduction
;
Stem Cells/cytology/metabolism
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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