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  • 1
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    Theory and experiments of disorder-induced resonance shifts and mode-edge broadening in deliberately disordered photonic crystal waveguides (2015)
    American Physical Society (APS)
    Details
    Publication Date: 2015-08-27
    Description: Author(s): Nishan Mann, Alisa Javadi, P. D. García, Peter Lodahl, and Stephen Hughes We study both theoretically and experimentally the effects of introducing deliberate disorder in a slow-light photonic crystal waveguide on the photon density of states. We introduce a theoretical model that includes both deliberate disorder through statistically moving the hole centers in the photo… [Phys. Rev. A 92, 023849] Published Wed Aug 26, 2015
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Photonic crystals with controlled disorder (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-08-11
    Description: Author(s): P. D. García, R. Sapienza, C. Toninelli, C. López, and D. S. Wiersma Photonic crystals are extremely sensitive to structural disorder even to the point of completely losing their functionalities. While, on one side, this can be detrimental for applications in traditional optical devices, on the other side, it gives also rise to very interesting new physics and maybe ... [Phys. Rev. A 84, 023813] Published Wed Aug 10, 2011
    Keywords: Quantum optics, physics of lasers, nonlinear optics, classical optics
    Print ISSN: 1050-2947
    Electronic ISSN: 1094-1622
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Receptor and betagamma binding sites in the alpha subunit of the retinal G protein transducin (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-01-17
    Description: Transmembrane receptors for hormones, neurotransmitters, light, and odorants mediate their cellular effects by activating heterotrimeric guanine nucleotide-binding proteins (G proteins). Crystal structures have revealed contact surfaces between G protein subunits, but not the surfaces or molecular mechanism through which Galphabetagamma responds to activation by transmembrane receptors. Such a surface was identified from the results of testing 100 mutant alpha subunits of the retinal G protein transducin for their ability to interact with rhodopsin. Sites at which alanine substitutions impaired this interaction mapped to two distinct Galpha surfaces: a betagamma-binding surface and a putative receptor-interacting surface. On the basis of these results a mechanism for receptor-catalyzed exchange of guanosine diphosphate for guanosine triphosphate is proposed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Onrust, R -- Herzmark, P -- Chi, P -- Garcia, P D -- Lichtarge, O -- Kingsley, C -- Bourne, H R -- CA-54427/CA/NCI NIH HHS/ -- GM-27800/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1997 Jan 17;275(5298):381-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143-0450, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8994033" target="_blank"〉PubMed〈/a〉
    Keywords: Aluminum Compounds/pharmacology ; Animals ; Binding Sites ; COS Cells ; Fluorides/pharmacology ; Guanosine 5'-O-(3-Thiotriphosphate)/metabolism ; Guanosine Diphosphate/metabolism ; Models, Molecular ; Mutation ; Phenotype ; *Protein Conformation ; Retinaldehyde/pharmacology ; Rhodopsin/*metabolism/pharmacology ; Rod Cell Outer Segment/metabolism ; Transducin/*chemistry/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Cavity quantum electrodynamics with Anderson-localized modes (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-13
    Description: A major challenge in quantum optics and quantum information technology is to enhance the interaction between single photons and single quantum emitters. This requires highly engineered optical cavities that are inherently sensitive to fabrication imperfections. We have demonstrated a fundamentally different approach in which disorder is used as a resource rather than a nuisance. We generated strongly confined Anderson-localized cavity modes by deliberately adding disorder to photonic crystal waveguides. The emission rate of a semiconductor quantum dot embedded in the waveguide was enhanced by a factor of 15 on resonance with the Anderson-localized mode, and 94% of the emitted single photons coupled to the mode. Disordered photonic media thus provide an efficient platform for quantum electrodynamics, offering an approach to inherently disorder-robust quantum information devices.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sapienza, Luca -- Thyrrestrup, Henri -- Stobbe, Soren -- Garcia, Pedro David -- Smolka, Stephan -- Lodahl, Peter -- New York, N.Y. -- Science. 2010 Mar 12;327(5971):1352-5. doi: 10.1126/science.1185080.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉DTU Fotonik, Department of Photonics Engineering, Technical University of Denmark, Orsteds Plads 343, DK-2800 Kgs. Lyngby, Denmark. lucs@fotonik.dtu.dk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20223981" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    All-optical radio-frequency modulation of Anderson-localized modes (2018)
    American Physical Society (APS)
    Details
    Publication Date: 2018-11-17
    Description: Author(s): G. Arregui, D. Navarro-Urrios, N. Kehagias, C. M. Sotomayor Torres, and P. D. García All-optical modulation of light relies on exploiting intrinsic material nonlinearities [V. R. Almeida et al. , Nature 431 , 1081 (2004) ]. However, this optical control is rather challenging due to the weak dependence of the refractive index and absorption coefficients on the concentration of free car... [Phys. Rev. B 98, 180202(R)] Published Fri Nov 16, 2018
    Keywords: Inhomogeneous, disordered, and partially ordered systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 6
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    Pif1 family helicases suppress genome instability at G-quadruplex motifs (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-05-10
    Description: The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases. Moreover, Pif1 helicases from organisms separated by more than 3 billion years of evolution suppressed DNA damage at G-quadruplex motifs in yeast. The G-quadruplex-induced damage generated in the absence of Pif1 helicases led to new genetic and epigenetic changes. Furthermore, when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680789/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3680789/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paeschke, Katrin -- Bochman, Matthew L -- Garcia, P Daniela -- Cejka, Petr -- Friedman, Katherine L -- Kowalczykowski, Stephen C -- Zakian, Virginia A -- R01 GM026938/GM/NIGMS NIH HHS/ -- R01 GM041347/GM/NIGMS NIH HHS/ -- R01 GM043265/GM/NIGMS NIH HHS/ -- England -- Nature. 2013 May 23;497(7450):458-62. doi: 10.1038/nature12149. Epub 2013 May 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23657261" target="_blank"〉PubMed〈/a〉
    Keywords: Base Sequence ; Conserved Sequence ; DNA Damage/genetics ; DNA Helicases/deficiency/genetics/*metabolism ; Epigenesis, Genetic ; Evolution, Molecular ; *G-Quadruplexes ; Gene Silencing ; Genetic Complementation Test ; *Genomic Instability ; Humans ; Molecular Sequence Data ; Mutation Rate ; Saccharomyces cerevisiae/*genetics/*metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Telomere Homeostasis/genetics
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 7
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    Two mechanisms of disorder-induced localization in photonic-crystal waveguides (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-10-07
    Description: Author(s): P. D. García, G. Kiršanskė, A. Javadi, S. Stobbe, and P. Lodahl The development of nanoscale optical devices requires high-quality nanocavities to mediate the optical feedback. Any fabrication method will generate imperfections that may induce light loss, limiting the device performance. However, in some cases such disorder may enable new functionalities as, for example, in state-of-the art photonic-crystal waveguides where localization originates from the random multiple scattering of light. Understanding the different mechanisms leading to this type of localization is crucial to exploit disorder as a resource as well as to design structures which are more robust against disorder. [Phys. Rev. B 96, 144201] Published Fri Oct 06, 2017
    Keywords: Inhomogeneous, disordered, and partially ordered systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 8
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    Optomechanical coupling in the Anderson-localization regime (2017)
    American Physical Society (APS)
    Details
    Publication Date: 2017-03-16
    Description: Author(s): P. D. García, R. Bericat-Vadell, G. Arregui, D. Navarro-Urrios, M. Colombano, F. Alzina, and C. M. Sotomayor-Torres Optomechanical crystals, purposely designed and fabricated semiconductor nanostructures, are used to enhance the coupling between the electromagnetic field and the mechanical vibrations of matter at the nanoscale. However, in real optomechanical crystals, imperfections open extra channels where the … [Phys. Rev. B 95, 115129] Published Tue Mar 14, 2017
    Keywords: Electronic structure and strongly correlated systems
    Print ISSN: 1098-0121
    Electronic ISSN: 1095-3795
    Topics: Physics
    Published by American Physical Society (APS)
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  • 9
    Electronic Resource
    Electronic Resource
    Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro (1988)
    [s.l.] : Nature Publishing Group
    Nature 333 (1988), S. 90-93 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Immunoglobulin heavy-chain binding protein (BiP) has been shown to be identical to the glucose regulated protein of relative molecular mass (Mr) 78,000 (GRP-78) and is a member of the evolutionarily conserved HSP-70 family of heat-shock related proteins4. Manipulations which inhibit N-linked ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/333090a0
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  • 10
    Electronic Resource
    Electronic Resource
    Substrate requirements for SRP-mediated targeting to the ER membrane (1987)
    Springer
    Molecular biology reports 12 (1987), S. 219-219 
    Details
    ISSN: 1573-4978
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00356909
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