ISSN:
0268-2605
Keywords:
diorganotin(IV) halides
;
N-methyl-2,2′-bisimidazole
;
Mössbauer
;
IR
;
NMR
;
cytostatic activity
;
Chemistry
;
Industrial Chemistry and Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The compounds [SnR2X2(MBIm)] (MBIm=N-methyl-2,2′-bisimidazole; R=Me, Et, Bu, Ph; X=Cl or Br) have been synthesized and characterized by IR, Raman, Mössbauer and NMR spectroscopy, and their capacity to inhibit tumour cell division has been assayed. Measurements of conductivity in acetonitrile show the adducts to behave as non-ionogens in this solvent. The IR, Raman and Mössbauer data suggest that all the complexes have analogous pseudo-octahedral coordination geometries, with the R groups trans and MBIm bidentate. The 1H NMR spectra show the MBIm ligand to be partially dissociated in CDCl3. The most active compounds against the established cell line KB were the butyl derivatives. © 1997 John Wiley & Sons, Ltd.
Additional Material:
4 Tab.
Type of Medium:
Electronic Resource
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