Springer Online Journal Archives 1860-2000
Summary Polymorphism of the properdin factor B (BF) was investigated using an agarose gel immunofixation electrophoresis in 487 unrelated healthy adult Japanese who were already typed for HLA-A,-B,-C, and C2. Besides the previously reported phenotypes in Japanese (S, FS, and F), a rare heterozygous phenotype (tentatively maned FTS) was observed once. The estimated allele frequencies for BS * S, BF * F, and BF * FT (F Tokyo) were 0.801, 0.198, and 0.001, respectively. The relative electrophoretic mobility of the variant band of type FTS was measured by Dr. G. Mauff to be F 0.75. The conversion fragment Bb of the type showed a double-banded pattern. BF hemolytic activity of the FTS individual was at the same level as other phenotypes. Statistical tests for the phenotypic data of BF with HLA-A,-B,-C, and C2 indicated the presence of the following significant associations in Japanese: Aw33-BF * F, A11-BF * S, Aw24-BF * S, B15-BF * F, B17-BF * F, Bw44-BF * F, B7-BF * S, Bw52-BF * S, Bw54-BF * S, Bw59-BF * S, Cw3-BF * F, C2 * AT-BF * F, and C2 * A′-BF*F.
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