Publication Date:
2015-07-15
Description:
Phytochemical investigation of the leaves of Phragmanthera capitata collected on Cassia spectabilis tree led to the isolation of two natural lactones, rel -(1 R ,5 S ,7 S )-7-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]nonan-3-one ( 1 ) and 4-{2-[ rel -(1 R ,3 R ,5 S )-7-oxo-2,6-dioxabicyclo[3.3.1]non-3-yl]ethyl}phenyl 3,4,5-trihydroxybenzoate ( 2 ) together with the known compounds betulinic acid ( 3 ), dodoneine ( 4 ), quercetin 3- O - α - L -rhamnopyranoside ( 5 ), quercetin 3- O - α - L -arabinofuranoside ( 6 ), quercetin ( 7 ), betulin ( 8 ), lupeol ( 9 ), and sitosterol ( 10 ). Their structures were established by means of modern spectroscopic techniques, and the relative configuration of compound 1 was confirmed by X-ray analysis. Compounds 1 and 2 were tested in vitro for their antiplasmodial activity against the Plasmodium falciparum chloroquine sensitive-strains NF54 and 3D7. Compound 2 exhibited good antiplasmodial activity against both strains with IC 50 of 2.4 and 4.9 μ M , respectively, while compound 1 was inactive.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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