Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Abstract The copolymers of methyl quaternized 2-dimethylaminopropyl acrylamide and styrene have been prepared. Studies were made of the binding of an anticancer drug, methotrexate by the copolymers, bovine serum albumin, and polyvinylpyrrolidone in aqueous solution. The first binding constants and the thermodynamic parameters in the course of the binding were evaluated and compared with those of a “binding probe”, methyl orange and its homologs in order to gain insight into the nature of drug binding and to apply the drug-polymer complex to a drug-delivery system. The nature and phenomena of drug binding with the polymers are discussed.
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