ISSN:
1432-1955
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Mice vaccinated with CL-14, a non-infective and non-pathogenic clone isolated from Trypanosoma cruzi CL strain, become protected against lethal challenge by infective trypomastigotes. It has been shown that animals infected with T. cruzi show polyclonal activation of B lymphocytes with an early production of several non-specific immunoglobulins. Vaccinated mice, however, have an early production of antigen-specific IgG1 and IgG2b. Considering the lack of infectivity of CL-14, our data strongly suggest a role for IgG1 and IgG2b in protection to T. cruzi.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004360050406
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