ISSN:
1662-9752
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
There is a growing need for remote biological sensing in both laboratory andharsh field environments. Sensing and detection of biological entities such as anthrax,Ebola and other micro-organisms of interest involves sampling of the environment,amplification, analysis and identification of the target DNA. A key component of sucha sensor is a low cost, portable, reusable, continuous flow polymerase chain reaction(PCR) thermal cycler. Fabrication with low temperature co-fired ceramics (LTCC)can provide a reusable low cost device capable of operating in a wide range ofenvironmentsThe design and manufacture of a prototype continuous flow micro-fluidic PCRdevice using low temperature co-fired ceramic is presented. Initial modeling of flowcharacteristics and heat transfer was carried out in SolidWorks™. The prototypedevice employs resistance heaters below the channels, buried and surfacethermocouples for temperature monitoring, and air gaps for thermal isolation
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/02/14/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.539-543.523.pdf
Permalink