Sub- and supercritical fluid chromatography (SubFC, SFC)
Chiral stationary phases (CSPs)
Direct resolution of racemates
Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
Fast resolutions of racemic compounds (sulfoxides, amino alcohols, and α-methylarylacetic acids derivatives) were achieved on a chiral microbore column using carbon dioxide and a polar methanol/dioxane modifier. The stationary phase used in this study contains the 3,5-dinitrobenzoyl derivative of R,R(-)-1,2-diaminocyclohexane (DACH-DNB) as the chiral moiety, anchored to a silica gel surface by covalent bonds. Both thermodynamic and kinetic separation performances were improved by using a super- or subcritical carbon dioxide mobile phase (SFC, SubFC).
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