ISSN:
1573-8221
Keywords:
heart transplantation
;
free oxygen radicals
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Experimental transplantation of the heart after preservation for different periods in St. Thomas solution showed that recovery of aerobic metabolism during reperfusion is impaired in the transplant weakened by ischemia because of activation of free-radical oxygen-dependent processes. Functional disorders were reversible after preservation for up to 4 h and involved adaptation changes in the recipient. After longer preservation, changes in the myocardium were irreversible. They manifested by failure of recovery of heart function caused by intracellular damage. In addition, pathological changes were observed in the recipient, caused by failure of antioxidant defense. This necessitates modification of the preserving solution in order to improve the transplant stability. Moreover, antioxidant drugs should be used for protecting the recipient.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445286
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