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  • 1
    Call number: PIK D 029-18-91896
    Description / Table of Contents: At this time when many have lost hope amidst conflicts, terrorism, environmental destruction, economic inequality and the breakdown of democracy, this beautifully written book outlines how to rethink and reform our key institutions - markets, corporations, welfare policies, democratic processes and transnational governance - to create better societies based on core principles of human dignity, sustainability, and justice. This new vision is based on the findings of over 300 social scientists involved in the collaborative, interdisciplinary International Panel on Social Progress. Relying on state-of-the-art scholarship, these social scientists reviewed the desirability and possibility of all relevant forms of long-term social change, explored current challenges, and synthesized their knowledge on the principles, possibilities, and methods for improving the main institutions of modern societies. Their common finding is that a better society is indeed possible, its contours can be broadly described, and all we need is to gather forces toward realizing this vision
    Type of Medium: Monograph available for loan
    Pages: XIII, 235 Seiten , Diagramme
    ISBN: 9781108424783 (print) , 9781108440929
    Language: English
    Note: Contents: Introduction: The Future is in Our Hands ; PART I SOURCES OF WORRY, REASONS FOR HOPE ; 1 Global Successes and Looming Catastrophes ; 2 Globalization and Technology: Choices and Contingencies ; 3 The Expanding Circle of Respect and Dignity ; 4 The Big Challenge ; PART II ACTING FOR SOCIAL PROGRESS ; 5 In Search of a New “Third Way” , 6 Reforming Capitalism , 7 From the Welfare State to the Emancipating State , 8 From Polaritics to Politics , Conclusion: Mobilizing Change- Makers
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 2
    Monograph available for loan
    Monograph available for loan
    Dordrecht : Springer
    Call number: PIK B 020-20-94151
    Type of Medium: Monograph available for loan
    Pages: XXV, 732 Seiten
    ISBN: 9781852333768 , 9781447125242
    Series Statement: Springer Finance
    Language: English
    Note: Contents: Continuous Path Processes ; Continuous-Path Random Processes: Mathematical Prerequisites ; Basic Concepts and Examples in Finance ; Hitting Times: A Mix of Mathematics and Finance ; Complements on Brownian Motion ; Complements on Continuous Path Processes ; A Special Family of Diffusions: Bessel Processes ; Jump Processes ; Default Risk: An Enlargement of Filtration Approach ; Poisson Processes and Ruin Theory ; General Processes: Mathematical Facts ; Mixed Processes ; Lévy Processes
    Location: A 18 - must be ordered
    Branch Library: PIK Library
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Medicine Research. ; Biology Research. ; Cytology. ; Internal medicine. ; Hematology. ; Biomedical Research. ; Cell Biology. ; Internal Medicine. ; Hematology.
    Description / Table of Contents: Live Donors of Tissue -- Deceased Tissue Donors -- Banking and Use of Umbilical Cord Blood -- Ocular tissue banking -- Banking of Heart Valves -- Cryopreservation and Banking of Haematopoietic Progenitor Cells -- Storage, Processing and Preservation -- Cryopreservation in tissue banking -- Sterilisation by Irradiation -- Screening the tissue donor for infectious agents -- Contamination in the Tissue Way -- Establishing a Quality System in a Tissue Establishment -- IT System requirements for Tissue and Cell Banking -- Ethical and Regulatory Aspects of Cell and Tissue Banking -- Human embryonic stem cell banking for clinical applications – 20 years from their isolation.
    Abstract: It has been 10 years since the first edition of ‘Essentials of Tissue Banking’ has been published. There is still relatively little published on the technical and scientific principles on routine tissue and cell banking based on scientific principles. The 1st edition was very successful and, after a 10 year gap, there is a need of an update and an expansion of the book’s remit. The format of the book follows that of the previous edition- split into 5 sections. Management of donors and the banking of common tissues and cells; Principles of storage and processing of tissues and cells; Ensuring the safety of the products by testing the donor, the tissues and the environment, supported by a quality system and an IT infrastructure- all working within the constraints of current regulatory and ethical environments. This edition however provides a significant update. Many the chapters have been completely rewritten by different experts. Like the 1st edition, they were given a free hand in the way they wrote their chapter, with a guideline that they had to be concise, clear and up to date. The authors were also asked to provide the scientific and technical basis that provides the rationale of the processes they describe. Also, the scope of the book has been somewhat extended. In view of the fact that many cellular therapies are now routinely practiced, 2 new chapters have been added: one on the banking of haematopoietic stem cells and one on human embryonic stem cells. They have been deliberately chosen to illustrate the extreme spectrum of cellular therapies from one of the simplest to one of the most complex. The intention of the book has remained the same: to cover and update banking of current practices in essential tissue and cell banking. It is therefore hoped that by keeping the book as concise and up to date as possible, it will find a place on the shelves of many tissue establishments.
    Type of Medium: Online Resource
    Pages: VIII, 288 p. 48 illus., 28 illus. in color. , online resource.
    Edition: 2nd ed. 2021.
    ISBN: 9783030716219
    DDC: 610.72
    Language: English
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  • 4
    Keywords: Ecology . ; Environment. ; Biotic communities. ; Ecology. ; Environmental Sciences. ; Ecosystems.
    Description / Table of Contents: Chapter 1: Introduction: Ecological Subsidies as a Framework for Understanding Contaminant Fate, Exposure, and Effects at the Land-Water Interface -- Part I: Ecological Subsidies Drive Exposure -- Chapter 2: Ecological Factors Controlling Insect-Mediated Methylmercury Flux from Aquatic to Terrestrial Ecosystems: Lessons Learned from Mesocosm and Pond Experiments -- Chapter 3: Pathways of Contaminant Transport Across the Aquatic-Terrestrial Interface: Implications for Terrestrial Consumers, Ecosystems and Management -- Part II: Exposure Drives Ecological Subsidies -- Chapter 4: Agriculture and Mining Contamination Contribute to a Productivity Gradient Driving Cross-Ecosystem Associations between Stream Insects and Riparian Arachnids -- Chapter 5: Cross-Ecosystem Linkages and Trace Metals at the Land-Water Interface -- Chapter 6: Metamorphosis and the Impact of Contaminants on Ecological Subsidies -- Part III: Other Global Stressors -- Chapter 7: Variables Affecting Resource Subsidies from Streams and Rivers to Land and their Susceptibility to Global Change Stressors -- Chapter 8: Beyond “Donors and Recipients”: Impacts of Species Gains and Losses Reverberate among Ecosystems due to Changes in Resource Subsidies -- Part IV: Management Applications and Tools -- Chapter 9: Practical Considerations for the Incorporation of Insect-Mediated Contaminant Flux into Ecological Risk Assessments -- Chapter 10: When Nutrients Become Contaminants in Aquatic Systems: Identifying Responses to Guide Terrestrial-Derived Detrital Endpoint Development for Managers -- Chapter 11: Mesocosms to Evaluate Aquatic-Terrestrial Contaminant Linkages using Aquatic Insect Emergence: Utility for Aquatic Life Criteria Development -- Chapter 12: Studying Effects of Contaminants on Aquatic-Terrestrial Subsidies: Experimental Designs using Outdoor and Indoor Mesocosms and Microcosms -- Part V: Syntheses -- Chapter 13: Ecological Networks as a Framework for Understanding and Predicting Contaminant Movement across the Land-Water Interface -- Chapter: 14: Synthesis: A Framework for Predicting the Dark Side of Ecological Subsidies.
    Abstract: This volume explores the effects of aquatic contaminants on ecological subsidies and food web exposure at the boundary of aquatic and terrestrial ecosystems. It provides the first synthesis of the findings and principles governing the “dark side” of contaminant effects on ecological subsidies. Furthermore, the volume provides extensive coverage of the tools being developed to help managers and researchers better understand the implications of contaminants movement and their effects on natural resources and ecosystem processes. Aquatic and terrestrial ecosystems are linked through movements of energy and nutrients which subsidize recipient food webs. As a result, contaminants that concentrate in aquatic systems because of the effects of gravity on water and organic matter have the potential to impact both aquatic and terrestrial ecosystem processes. Within the last decade, increased attention has been paid to this phenomenon, particularly the effects of aquatic contaminants on resource and contaminant export to terrestrial consumers, and the potential implications for management. This volume, curated and edited by three field leaders, incorporates empirical results, management applications and theoretical synthesis and is a key reference for academics, government researchers and consultants.
    Type of Medium: Online Resource
    Pages: XV, 383 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030494803
    DDC: 577
    Language: English
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  • 5
    Keywords: Medical sciences. ; Neurology . ; Orthopedics. ; Pediatrics. ; Health Sciences. ; Neurology. ; Orthopaedics. ; Pediatrics.
    Description / Table of Contents: Chapter 1) Introduction -- Chapter 2) History of Neurosurgical Treatment for Spasticity -- Chapter 3) Anatomical Bases of Tone and Spasticity -- Chapter 4) Assessment of Spasticity in Adults -- Chapter 5) Decision-Making for Adults with Disabling Spasticity -- Chapter 6) Intrathecal Baclofen Therapy -- Chapter 7) Botulinum Toxin Injections for Spasticity -- Chapter 8) Peripheral Neurotomy -- Chapter 9) Surgery in the Dorsal Root Entry Zone -- Chapter 10) Spasticity and Hypertonia in Cerebral Palsy: Mechanisms and Surgical Implications -- Chapter 11) Assessment of Spasticity in Pediatric Patients -- Chapter 12) Decision-Making for Neurosurgical Treatment in Children with Disabling Spasticity -- Chapter 13) Dorsal Rhizotomy for Children with Cerebral Palsy -- Chapter 14) Neuro-Orthopedic Surgery for Correction of Spastic Disorders -- Chapter 15) Management of Neurogenic Overactive Bladder -- Chapter 16) Brief on Decision-Making for Neurosurgery of Spasticity in Adults and Children -- Chapter 17) Scales and Forms to Be Used in Practice.
    Abstract: The book, in its second edition, is devoted to the neurosurgical management of spasticity and focal dystonia. Starting with a chapter on the anatomical and physiological bases of spasticity and a short history of its neurosurgical treatment, it describes the neurosurgical methods currently available. As management differs between adults and children, the book is also structured accordingly, including evaluation, decision-making, Intrathecal Baclofen therapy (ITB), Botulinum toxin therapy and Surgery. The large spectrum of scales for assessing hypertonia, spasticity, dystonia, contracture and joint/bone deformities, as well as the scoring systems for quantifying functional abilities are critically reviewed. Beyond ITB, the neurosurgical options covered include the microsurgical procedures focusing on the peripheral nerves, dorsal roots, Dorsal Root Entry Zone and spinal cord, and their intra-operative monitoring. In this second edition, the orthopedic surgical interventions available will take a large place, either as alternative solutions , or even better as important complements after spasticity be solved by the neurosurgical treatments. Based on surgical experience collected with more than a thousand and eight-hundred patients, the book gathers the most important aspects of our present understanding, presented using a practical, educational approach. It stresses the importance of a multidisciplinary approach, including neurologists, pediatricians and rehabilitation specialists. Close collaborations with other surgical disciplines like orthopedic surgery and neuro-urology are outlined.
    Type of Medium: Online Resource
    Pages: XV, 359 p. 179 illus., 110 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030927172
    DDC: 610
    Language: English
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  • 6
    Keywords: Medicine Research. ; Biology Research. ; Pharmacology. ; Drug delivery systems. ; Regenerative medicine. ; Biomedical Research. ; Pharmacology. ; Drug Delivery. ; Regenerative Medicine and Tissue Engineering.
    Description / Table of Contents: Approaches Towards Synthetic Signal Transduction in Phospholipid Bilayers -- Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications -- Metal-organic Framework—Polymer Mixed-Matrix Membranes -- Insights into Adaptive Selforganized Supramolecular Structures from Molecular Modeling and Visualization -- Self-Assembled Metallacages as Drug Delivery Systems: Design Concepts and Challenge -- Functional Microporous Polymer Networks: Synthesis and Applications -- A Story on Carbon Dioxide and its Hydration -- Inverse Design and Hierarchical Multiscale Modelling of Biological Matter -- DNA-Directed Self-assembly of Macromolecular Structures -- Luminescent Complexes and their Assemblies : from Understanding to Artificial Virus -- Tailor-Made Polymers and Nanoparticles for Applications in Nanomedicine -- Squalene-based Nanomedicines : An Original and Efficient Approach for the Treatment of Neurological Disorders without Crossing the Blood-Brain Barrier -- Biodegradable Nanoparticles for Specific Drug Transport -- Multivalent rotaxanes designed as antibiofilm agents -- Measuring Ionic Transport through Lipid Bilayers -- Polymeric Carriers for Transporting Nucleic Acids - Contributions to the Field -- Smart Polymeric Materials for Drug Delivery -- Supramolecular Guanosine-quadruplex Hydrogels and Hydrogel Composites for Cell Growth Applications -- Hydrogelation of Chitosan with Monoaldehydes towards Biomaterials with Tuned Properties -- Inorganic Nanoarticles as Free Radical Scavengers -- A Microbiological Epilogue - Nosocomial Infections -- Molecular Dynamic Simulations and In Silico Analysis of Supramolecular Self-Assembled Structures -- Validation of the Non Toxicity of Non Viral Genetic -- Kinetics Transport of Ions/Water Through Nano-Scale Channels : Review And Update.
    Abstract: This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations. The challenge is to understand the mechanisms of transport through tissues particularly in the therapeutic treatment of a disease where the active drug must be delivered directly to diseased cells without affecting healthy cells. As a result, smaller quantities of active substances can be used to treat the disease. Another interest concerns new ways to administer gene therapy. If genes are often delivered to their target cells by adapted viruses, the supramolecular non-viral ‘vectors’ using dynamic nano-frameworks and nano-structures are presented. In addition, it is important to reconstruct damaged tissues by mimicking natural processes in cells and polymers, such as tissue engineering and self-healing. Different options are here discussed: e.g. hydrogels based on chitosan, a carbohydrate polymer, are proving especially promising for tissue engineering and drug delivery. For controlled delivery of drugs or other biologically active compounds, hydrogels sensitive to the most important stimuli in the human body, such as temperature, pH, ionic strength, glucose and biomolecules released by the organism in pathological conditions have been developed. Finally, to assist and validate the experimental studies, computer modelling and simulations of large-sized molecular structures and systems using different molecular dynamics and quantum mechanical techniques are developed based on the experimental and chemistry synthesis. This book is of great interest for graduate students, researchers and health professionals interested in acquiring a better understanding of the mechanisms of medical treatments. In addition, it provides numerous tools to develop better therapies for human diseases.
    Type of Medium: Online Resource
    Pages: XII, 371 p. 174 illus., 133 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030574567
    DDC: 610.72
    Language: English
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  • 7
    Keywords: Environmental management. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Environmental monitoring. ; Water-power. ; Renewable energy sources. ; Environmental chemistry. ; Environmental Management. ; Environmental Engineering/Biotechnology. ; Environmental Monitoring. ; Hydroenergy. ; Renewable Energy. ; Environmental Chemistry.
    Description / Table of Contents: Modelling the effect of the pumping variations’ on the groundwater quality in the semi-arid Aquifers -- Assessment of Groundwater Aquifer Impact from Artificial Lagoons and the Re-use of Wastewater in Qatar -- Temporal groundwater level prediction using multivariate geostatistics: a case study from Sfax superficial aquifer (Tunisia) -- Integration of electromagnetic method and resistivity depth sounding in the evaluation of groundwater potentials of Araromi phases 1 and 2, Akungba-Akoko, southwestern Nigeria -- Contribution to the Study of Fluoride Ion Concentrations in Groundwater and its Impact on the Desert Areas of South-eastern Algeria -- Groundwater stability assessment with geospatial modeling using GIS: a case study of ILLIZI town, Algeria -- Efficiency assessment of AHP and fuzzy AHP in suitability mapping for artificial recharging (Case study: south of Kashan basin, Isfahan, Iran) -- Statistical methods for the evaluation of water quality -- Research on innovative materials and technologies for water treatment and water desalination: A conceptual analysis from 1969 to 2019 -- The Microbial and Physicochemical Analysis and Treatment of Groundwater of South Punjab, Pakistan -- Removal of cyanotoxins in drinking water using advanced oxidation processes -- Microplastic detection and analysis in water samples -- Column Adsorption Studies of phenolic compounds on nanoparticles synthesized from Moroccan phosphate rock -- Summary of Field Trial Results of the Treatment of Contaminated Water using Non-fouling Super Hydrophilic Functionalized Ceramic Membranes -- Preliminary study for phosphate recovery from starch factory wastewater using porous aluminum -- Removal of organic compounds from olive mill wastewater by flotation-anaerobic-aerobic processes and lime treatment -- Sustainable Wastewater Treatment Technologies for Appropriate Agricultural use in Jordan.
    Abstract: This book addresses challenges and opportunities in the Energy-Water-Environment (EWE) nexus, with a particular focus on research and technology development requirements in harsh desert climates. Its chapters include selected contributions presented during the 1st international conference on sustainable Energy-Water-Environment nexus in desert climates (ICSEWEN-19) held at the Qatar Environment and Energy Research Institute (QEERI) in Doha, Qatar in December 2019. This volume is comprised of three main chapters, each describing important case studies and progress on water, energy and environmental questions. A fourth chapter on policies and community outreach on these three areas is also included. This compilation aims to bridge the gap between research and industry to address the socioeconomic impacts of the nexus imbalance as perceived by scientists, industrial partners, and policymakers. The content of this book is of particular importance to graduate students, researchers and decision makers interested in understanding water, energy and environmental challenges in arid areas. Re searchers in environmental and civil engineering, chemistry, hydrology and environmental science can also find unique in-situ observations of the current nexus imbalance in deserts climate to validate their investigations. It is also an invaluable guide for industry professionals working in water, energy, environment and food sectors to understand the rapidly evolving landscape of the EWE nexus in arid areas. The analyses, observations and lessons-learned summarized herein are applicable to other arid areas outside North Africa and the Arabian Peninsula as well, such as central Australia, the southwest of the United States and deserts in central Asia.
    Type of Medium: Online Resource
    Pages: XXVII, 843 p. 700 illus., 588 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030760816
    Series Statement: Advances in Science, Technology & Innovation, IEREK Interdisciplinary Series for Sustainable Development,
    DDC: 333.7
    Language: English
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  • 8
    Keywords: Geography. ; Ecology . ; Geomorphology. ; Climatology. ; Biodiversity. ; Geography. ; Ecology. ; Geomorphology. ; Climate Sciences. ; Biodiversity.
    Description / Table of Contents: Geographic Uniqueness of the Sierra Nevada in the Context of the Mid-latitude Mountains -- Biotic Uniqueness of the Sierra Nevada as a Hotspot of Biodiversity -- Singular Cultural Landscapes of the Sierra Nevada -- Scientific Knowledge Generated in the Sierra Nevada: Bibliographic Review in WOS Since 1970 -- The Geological Setting -- Glacial Geomorphology of the Massif -- Reconstruction of Past Environments Using Lake Sedimentary Records -- Modern Periglacial Environment and Permafrost -- Variability and Recent Trends -- Snow Dynamics, Hydrology and Erosion -- Altitudinal Migrations and Changes in the Composition of High Mountain Plant Communities -- Altitudinal Migrations and Changes in the Composition of Animal Communities -- Dynamics of Forest Systems Under Land Use and Climatic Change Scenarios -- Resilience of Montane Ecosystems to Major Disturbances (fires) -- Migrations Rivers -- High Mountain Lakes as Remote Sensors of Global Change -- Paleolimnological Indicators of Climate Change -- Atmospheric Inputs and Drastic Alterations in Food Webs and Ecosystems Processes -- Remote Sensors Monitoring of Functional Aspects of Terrestrial and Aquatic Ecosystems -- Managing the Uniqueness of Sierra Nevada Ecosystems Under Global Change: Adaptive Projects -- Incorporation of Traditional Knowledge in Agrobiodiversity for a Sustainable Mountain Economy -- Data Model, E-infrastructure Services and Virtual Research Environments (VRE) -- Advancing Open Science in Sierra Nevada: Current Citizen Science Campaigns -- Filling the Gaps in Research, Management and Social Connection.
    Abstract: This book covers the landscape, geography and environment of the Sierra Nevada in Spain. The Sierra Nevada hosted the last glaciers in southern Europe. Today, it is one of the most important centers of plant diversity in the western Mediterranean and one of the most outstanding in Europe. This massif has ideal conditions to analyze past environments as well as the effects of global change on ecosystems. This can be seen in the large number of projects that are being conducted within the umbrella of the Sierra Nevada Global Change Observatory. This book summarizes all the scientific knowledge available about this massif, from the geomorphological and ecological perspectives to the recent spatial adaptive management and Open Science initiatives. Focusing on the very sensitive mountain environment of Sierra Nevada, the book intends to be a reference for many people interested in mountain processes. The audience would include scientists from all disciplines, but it would also target on an audience beyond the academia (territorial managers, environmentalists, mountaineers, politicians, technicians, etc.).
    Type of Medium: Online Resource
    Pages: XVII, 421 p. 171 illus., 156 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030942199
    DDC: 910
    Language: English
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geomorphology. ; Sedimentology. ; Physical geography. ; Geomorphology. ; Sedimentology. ; Earth System Sciences.
    Description / Table of Contents: Chapter 1 - Introduction -- Part 1 - Regional Setting -- Chapter 2. Quaternary climate variability and periglacial dynamics -- Chapter 3 - Periglacial Landforms Across Europe -- Part 2 - Periglacial Landforms in Southern Europe -- Chapter 4. The Iberian Peninsula -- Chapter 5. The Italian Peninsula -- Chapter 6. The Balkans (without Carpathians) -- Chapter 7. The Anatonian Peninsula -- Chapter 8. The Mediterranean islands -- Part 3 - Periglacial Landforms in Central and Eastern Europe -- Chapter 9. European Alps -- Chapter 10. The Central European Variscan ranges -- Chapter 11. The Carpathians -- Chapter 12. The North European Plain -- Part 4 - Periglacial Landforms in Northern Europe -- Chapter 13. Great Britain and Ireland -- Chapter 14. Scandinavia -- Chapter 15. Iceland -- Part 5 - Conclusions -- Chapter 16. The periglaciation of Europe.
    Abstract: This book comprehensively presents the geography of landforms linked to periglacial processes across Europe. The landscape of the European cold climate regions, both at high latitudes and in mountainous environments, represent the lingering, minimal expression of the glaciers. In addition, periglacial elements can be found in temperate regions, where temperatures no longer favor periglacial processes, so landforms are therefore inherited from previous cold phases. The book is divided into five parts: an introductory section on climate variability responsible for periglacial dynamics across Europe; a second part including 3 blocks on periglacial landforms in southern, central and northern Europe; and a final chapter providing a more general perspective on the impact of periglacial processes on the landscape of Europe. The book offers a valuable reference guide for scientists from all disciplines interested in cold climate processes, as well as readers outside academia (territorial managers, environmentalists, mountaineers, politicians, engineers, etc.). .
    Type of Medium: Online Resource
    Pages: XII, 523 p. 109 illus., 104 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031148958
    DDC: 551.41
    Language: English
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  • 10
    Keywords: Medical genetics. ; Cancer. ; Medicine Research. ; Biology Research. ; Proteins . ; Proteins. ; Medical Genetics. ; Cancer Biology. ; Biomedical Research. ; Protein Biochemistry. ; Proteins.
    Description / Table of Contents: Preface: Dedication to Susan Lindquist -- Part I: Structure -- Structural and Biochemical properties of Hsp40/Hsp70 chaperone system -- The TRiC/CCT chaperonin and its role in uncontrolled proliferation -- Regulation of Hsf1 and the heat shock response -- Part II: Function -- Challenging proteostasis: Role of the chaperone network to control aggregation-prone proteins in human disease -- The multifaceted role of HSF1 in tumorigenesis -- Chaperome networks – redundancy and implications for cancer treatment -- Chaperones in the tumor microenvironment -- The impact of the ER unfolded protein response on cancer initiation and progression: Therapeutic implications -- Part III: Therapies -- The right tool for the job: an overview of Hsp90 inhibitors -- Lessons learned from proteasome inhibitors, the paradigm for targeting protein homeostasis in cancer -- Reflections and outlook on targeting HSP90, HSP70 and HSF1 in cancer: A personal perspective.
    Abstract: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
    Type of Medium: Online Resource
    Pages: VIII, 182 p. 31 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030402044
    Series Statement: Advances in Experimental Medicine and Biology, 1243
    DDC: 616.042
    Language: English
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