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  • 1
    Online Resource
    Online Resource
    Guidelines for Laboratory Quality Managers (2023)
    Cham :Springer International Publishing :
    Details
    Keywords: Food science. ; Food Analysis. ; Chemistry. ; Chemistry, Organic. ; Food Science. ; Food Chemistry. ; Organic Chemistry.
    Description / Table of Contents: Laboratory management and ISO 17025:2017 -- Essential for Quality management in testing laboratories -- Preparing for analysis: the analytical method -- Statistics for the Quality Control Laboratory -- Uncertainty measurement -- Control Charts and Process capability -- Risk Management.
    Abstract: This useful and extensive set of guidelines is designed to assist food control laboratories in gainingaccreditation from an internationally recognized external body, providing all of the necessary information and practices in an easy-to-read, step-by-step fashion. Authored by an experienced consultant for laboratory accreditation in many different countries, with this text food control lab owners now have all of the up-to-date information they need to gain accreditation in a single source. Guidelines for Laboratory Quality Managers covers the essentials for quality management in the food control laboratory, from testing processes to current quality management systems. The ISO standards for accreditation are extensively explored, including managerial requirements,organizational aspects, complaint handling procedures, internal audits, and sampling. An entire section is dedicated to the implementation of managerial and technical requirements from quality control to program monitoring and evaluation. Analysis selection, preparation, and validation is covered extensively, and an entire section is dedicated to basic statistics from data presentation todistribution. Each section comes with helpful tips for lab managers plus definitions and terms. Comprehensive, easy-to-use and up-to-date, Guidelines for Laboratory Quality Managers isthe guide for accreditation for food control laboratories. .
    Type of Medium: Online Resource
    Pages: XV, 160 p. 34 illus., 29 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031117244
    Series Statement: Integrating Food Science and Engineering Knowledge Into the Food Chain, 14
    URL: https://doi.org/10.1007/978-3-031-11724-4
    DOI: 10.1007/978-3-031-11724-4
    DDC: 641.3
    Language: English
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  • 2
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    Evaluation of recurrent hyphema after trabeculectomy with ultrabiomicroscopy 50-80 MHz: a case report (2012)
    BioMed Central
    Details
    Publication Date: 2012-10-05
    Description: Background: Hyphema is a complication that can occur after glaucoma filtering surgery. Biomicroscopic examination of the anterior segment is commonly used to diagnose it and gonioscopy may provide a useful support to find the source of the haemorrhage. Unfortunately, when the blood hides the structure of the anterior segment the gonioscopic examination fails. In this case we performed ultrabiomiscroscopy with 50--80 MHz probes to overcome the limits of gonioscopy. The use of this technique to study the anterior segment of the eye has previously been reported in literature, but we illustrates its importance for performing a correct diagnosis in a specific case of hyphema.Case presentationWe report a case of a sixty-year-old caucasian male with recurrent hyphema in the left eye. The episodes of hyphema were four in two years and the patient came to the hospital for the first time in the last occasion. The past episodes were managed with topical corticosteroids and mydriatic drops. He referred surgical trabeculectomy in both eyes 5 years before the first symptoms and no specific eye trauma before the first episode. The examination of the anterior segment revealed a 2 mm hyphema in the left eye due to blood leakage through the superior iridectomy. Gonioscopy could not identify the source of the haemorrhage. B-scan ultrasound and ultrabiomiscroscopy, with 50--80 MHz probes, were performed. Ultrabiomiscroscopy, mainly with the probe of 80 MHz, provided images of high resolution of the structures of the anterior segment and it allowed the visualization of an abnormal vessel at the inner margin of the trabeculectomy opening, probably responsible of the recurrent hyphema. Conclusion: Ultrabiomicroscopy proved to be a useful diagnostic technique for identifying the cause of the recurrent hyphema when other examination techniques are not applicable.
    Electronic ISSN: 1756-0500
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 3
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    Evaluation of recurrent hyphema after trabeculectomy with ultrabiomicroscopy 50-80 MHz: a case report (2012)
    BioMed Central
    Details
    Publication Date: 2012-01-01
    Electronic ISSN: 1756-0500
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 4
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    DRUDIT: web-based DRUgs DIscovery Tools to design small molecules as modulators of biological targets (2019)
    Oxford University Press
    Details
    Publication Date: 2019-10-12
    Description: Motivation New in silico tools to predict biological affinities for input structures are presented. The tools are implemented in the DRUDIT (DRUgs DIscovery Tools) web service. The DRUDIT biological finder module is based on molecular descriptors that are calculated by the MOLDESTO (MOLecular DEScriptors TOol) software module developed by the same authors, which is able to calculate more than one thousand molecular descriptors. At this stage, DRUDIT includes 250 biological targets, but new external targets can be added. This feature extends the application scope of DRUDIT to several fields. Moreover, two more functions are implemented: the multi- and on/off-target tasks. These tools applied to input structures allow for predicting the polypharmacology and evaluating the collateral effects. Results The applications described in the article show that DRUDIT is able to predict a single biological target, to identify similarities among biological targets, and to discriminate different target isoforms. The main advantages of DRUDIT for the scientific community lie in its ease of use by worldwide scientists and the possibility to be used also without specific, and often expensive, hardware and software. In fact, it is fully accessible through the WWW from any device to perform calculations. Just a click or a tap can start tasks to predict biological properties for new compounds or repurpose drugs, lead compounds, or unsuccessful compounds. To date, DRUDIT is supported by four servers each able to execute 8 jobs simultaneously. Availability and implementation The web service is accessible at the www.drudit.com URL and its use is free of charge. Supplementary information Supplementary data are available at Bioinformatics online.
    Print ISSN: 1367-4803
    Electronic ISSN: 1460-2059
    Topics: Biology , Computer Science , Medicine
    Published by Oxford University Press
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  • 5
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    In Silico Identification of Small Molecules as New Cdc25 Inhibitors through the Correlation between Chemosensitivity and Protein Expression Pattern (2021)
    Molecular Diversity Preservation International
    Details
    Publication Date: 2021-04-02
    Description: The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as Cdc25 modulators by applying a mixed ligand-structure-based approach and taking advantage of the correlation between the chemosensitivity of selected structures and the protein expression pattern of the proposed target. In the first step of the in silico protocol, a set of molecules acting as Cdc25 inhibitors were identified through a new ligand-based protocol and the evaluation of a large database of molecular structures. Subsequently, induced-fit docking (IFD) studies allowed us to further reduce the number of compounds biologically screened. In vitro antiproliferative and enzymatic inhibition assays on the selected compounds led to the identification of new structurally heterogeneous inhibitors of Cdc25 proteins. Among them, J3955, the most active inhibitor, showed concentration-dependent antiproliferative activity against HepG2 cells, with GI50 in the low micromolar range. When J3955 was tested in cell-cycle perturbation experiments, it caused mitotic failure by G2/M-phase cell-cycle arrest. Finally, Western blotting analysis showed an increment of phosphorylated Cdk1 levels in cells exposed to J3955, indicating its specific influence in cellular pathways involving Cdc25 proteins.
    Print ISSN: 1661-6596
    Electronic ISSN: 1422-0067
    Topics: Chemistry and Pharmacology
    Published by Molecular Diversity Preservation International
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  • 6
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    Evaluation of recurrent hyphema after trabeculectomy with ultrabiomicroscopy 50-80 MHz: a case report (2012)
    BioMed Central
    Details
    Publication Date: 2012-10-04
    Description: Background Hyphema is a complication that can occur after glaucoma filtering surgery. Biomicroscopic examination of the anterior segment is commonly used to diagnose it and gonioscopy may provide a useful support to find the source of the haemorrhage. Unfortunately, when the blood hides the structure of the anterior segment the gonioscopic examination fails. In this case we performed ultrabiomiscroscopy with 50–80 MHz probes to overcome the limits of gonioscopy. The use of this technique to study the anterior segment of the eye has previously been reported in literature, but we illustrates its importance for performing a correct diagnosis in a specific case of hyphema. Case presentation We report a case of a sixty-year-old caucasian male with recurrent hyphema in the left eye. The episodes of hyphema were four in two years and the patient came to the hospital for the first time in the last occasion. The past episodes were managed with topical corticosteroids and mydriatic drops. He referred surgical trabeculectomy in both eyes 5 years before the first symptoms and no specific eye trauma before the first episode. The examination of the anterior segment revealed a 2 mm hyphema in the left eye due to blood leakage through the superior iridectomy. Gonioscopy could not identify the source of the haemorrhage. B-scan ultrasound and ultrabiomiscroscopy, with 50–80 MHz probes, were performed. Ultrabiomiscroscopy, mainly with the probe of 80 MHz, provided images of high resolution of the structures of the anterior segment and it allowed the visualization of an abnormal vessel at the inner margin of the trabeculectomy opening, probably responsible of the recurrent hyphema. Conclusion Ultrabiomicroscopy proved to be a useful diagnostic technique for identifying the cause of the recurrent hyphema when other examination techniques are not applicable.
    Electronic ISSN: 1756-0500
    Topics: Biology , Medicine
    Published by BioMed Central
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  • 7
    Electronic Resource
    Electronic Resource
    Dependence of the Transient Enhanced Diffusion, of B in Si, upon B Concentration and Ion Implanted Dose (2001)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 82-84 (Nov. 2001), p. 177-182 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/26/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.82-84.177.pdf
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Upward drawings of triconnected digraphs (1994)
    Springer
    Algorithmica 12 (1994), S. 476-497 
    Details
    ISSN: 1432-0541
    Keywords: Planarity ; Automatic graph drkwing ; Hierarchical structures ; Max-flow ; st-Digraphs ; Acyclic digraphs ; Ordered sets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract A polynomial-time algorithm for testing if a triconnected directed graph has an upward drkwing is presented. An upward drkwing is a planar drkwing such that all the edges flow in a common direction (e.g., from bottom to top). The problem arises in the fields of automatic graph drkwing and ordered sets, and has been open for several years. The proposed algorithm is based on a new combinatorial characterization that maps the problem into a max-flow problem on a sparse network; the time complexity isO(n+r 2) , wheren is the number of vertices andr is the number of sources and sinks of the directed graph. If the directed graph has an upward drkwing, the algorithm allows us to construct one easily.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01188716
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  • 9
    Electronic Resource
    Electronic Resource
    Uncertainty of measurement and legislative limits (1998)
    Springer
    Accreditation and quality assurance 3 (1998), S. 335-337 
    Details
    ISSN: 1432-0517
    Keywords: Key words Measurement uncertainty ; Legislative limits ; α and β errors ; Compliance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract  The uncertainty affecting analytical measurements has to be taken into account when evaluating compliance of suspect matrices to legislative limits. To this aim Type 1 and 2 errors must be considered. This necessarily leads to the evaluation of the minimum detectable inadmissible signal, from which the minimum detectable inadmissible concentration can be obtained. The signal of suspect matrices thus has to be compared with the minimum detectable inadmissible signal. This paper aims to discuss practical problems involved in the comparison.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007690050256
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  • 10
    Electronic Resource
    Electronic Resource
    The evaluation of a planning tool through the landscape ecology concepts and methods (2005)
    Bradford, West Yorkshire : Emerald
    Management of environmental quality 16 (2005), S. 55-70 
    Details
    ISSN: 1477-7835
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Purpose - Landscape ecology represents an area of theoretical and empirical support of spatial planning, providing parameters such as heterogeneity, connectivity and fragmentation. The aim of this study was to use these parameters to evaluate the choices of a real planning tool to protect the biodiversity, to evaluate the applicability limits of concepts and methods used. Design/methodology/approach - This was achieved by analysing the selected spatial indices and their dependency scale, and by the comparison of these results with regard to spatial biotic parameters estimations (birds and mammals). Findings - The study confirmed the scale's effect on the indices, unstable at the adopted resolution for extensions up to 6,000-7,000 meters. The selected indices permitted appreciation of the low effectiveness of the real planning tool in improving conservation of biodiversity. The paper suggests that empirical studies and predictive knowledge at different scales are urgent in this field. To preserve biodiversity, the choices of planning scale should primarily comply with the spatial needs of the various species. Originality/value - Evaluates a real planning tool to protect biodiversity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/14777830510574344
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