Publication Date:
2015-10-03
Description:
Motivation facilitates recovery after neuronal damage, but its mechanism is elusive. It is generally thought that the nucleus accumbens (NAc) regulates motivation-driven effort but is not involved in the direct control of movement. Using causality analysis, we identified the flow of activity from the NAc to the sensorimotor cortex (SMC) during the recovery of dexterous finger movements after spinal cord injury at the cervical level in macaque monkeys. Furthermore, reversible pharmacological inactivation of the NAc during the early recovery period diminished high-frequency oscillatory activity in the SMC, which was accompanied by a transient deficit of amelioration in finger dexterity obtained by rehabilitation. These results demonstrate that during recovery after spinal damage, the NAc up-regulates the high-frequency activity of the SMC and is directly involved in the control of finger movements.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sawada, Masahiro -- Kato, Kenji -- Kunieda, Takeharu -- Mikuni, Nobuhiro -- Miyamoto, Susumu -- Onoe, Hirotaka -- Isa, Tadashi -- Nishimura, Yukio -- New York, N.Y. -- Science. 2015 Oct 2;350(6256):98-101. doi: 10.1126/science.aab3825. Epub 2015 Oct 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan. Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. ; Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan. Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies, SOKENDAI, Hayama 240-0193, Japan. ; Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. ; Department of Neurosurgery, Sapporo Medical University, Sapporo 060-8543, Japan. ; Division of Bio-Function Dynamics Imaging, RIKEN Center for Life Science Technologies, Kobe 650-0047, Japan. ; Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan. Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies, SOKENDAI, Hayama 240-0193, Japan. Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Tokyo 102-0076, Japan. yukio@nips.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26430122" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Fingers/innervation/physiopathology
;
*Functional Laterality
;
GABA-A Receptor Agonists/administration & dosage/pharmacology
;
Macaca
;
Motivation
;
*Motor Skills
;
Movement
;
Muscimol/administration & dosage/pharmacology
;
Nucleus Accumbens/*physiopathology
;
*Recovery of Function
;
Sensorimotor Cortex/drug effects/physiopathology
;
Spinal Cord Injuries/*physiopathology/*psychology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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