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  • 1
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    Stark broadening of Xe VIII spectral lines (2015)
    Oxford University Press
    Details
    Publication Date: 2015-10-09
    Description: Stark broadening parameters have been calculated for 60 spectral lines of Xe viii , for broadening by electron, proton, and He iii impacts. For calculations, the semiclassical perturbation approach in the impact approximation has been used. The widths and shifts are provided for temperatures from 20 000 K to 500 000 K and for an electron density of 10 17 cm –3 . Obtained results have been used to study the influence of Stark broadening on spectral lines in DO white dwarf atmospheres and it has been found that exist broad layers where this broadening mechanism is dominant in comparison with thermal Doppler broadening.
    Print ISSN: 0035-8711
    Electronic ISSN: 1365-2966
    Topics: Physics
    Published by Oxford University Press
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  • 2
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    HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-10-18
    Description: The conserved heat shock transcription factor-1 (HSF-1) is essential to cellular stress resistance and life-span determination. The canonical function of HSF-1 is to regulate a network of genes encoding molecular chaperones that protect proteins from damage caused by extrinsic environmental stress or intrinsic age-related deterioration. In Caenorhabditis elegans, we engineered a modified HSF-1 strain that increased stress resistance and longevity without enhanced chaperone induction. This health assurance acted through the regulation of the calcium-binding protein PAT-10. Loss of pat-10 caused a collapse of the actin cytoskeleton, stress resistance, and life span. Furthermore, overexpression of pat-10 increased actin filament stability, thermotolerance, and longevity, indicating that in addition to chaperone regulation, HSF-1 has a prominent role in cytoskeletal integrity, ensuring cellular function during stress and aging.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403873/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4403873/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baird, Nathan A -- Douglas, Peter M -- Simic, Milos S -- Grant, Ana R -- Moresco, James J -- Wolff, Suzanne C -- Yates, John R 3rd -- Manning, Gerard -- Dillin, Andrew -- 1K99AG042495-01A1/AG/NIA NIH HHS/ -- 5P41RR011823-17/RR/NCRR NIH HHS/ -- 8 P41 GM103533-17/GM/NIGMS NIH HHS/ -- P01 AG031097/AG/NIA NIH HHS/ -- P40 OD010440/OD/NIH HHS/ -- P41 GM103533/GM/NIGMS NIH HHS/ -- R01AG027463-04/AG/NIA NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Oct 17;346(6207):360-3. doi: 10.1126/science.1253168.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94720, USA. ; Department of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI 48109, USA. ; Scripps Research Institute, La Jolla, CA 92037, USA. ; Genentech, South San Francisco, CA 94080, USA. ; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94720, USA. dillin@berkeley.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25324391" target="_blank"〉PubMed〈/a〉
    Keywords: Actins/metabolism ; Animals ; Caenorhabditis elegans/genetics/*physiology ; Caenorhabditis elegans Proteins/genetics/*pharmacology/*physiology ; Cytoskeleton/*physiology/ultrastructure ; Heat-Shock Response/genetics/*physiology ; Hot Temperature ; *Longevity ; RNA Interference ; Transcription Factors/genetics/*physiology ; Troponin C/genetics/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming (2019)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2019
    Description: 〈p〉Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires both epigenetic landscape reshaping and global remodeling of cell identity, structure, basic metabolic processes, and organelle form and function. We hypothesize that variable regulation of the proteostasis network and its influence upon the protein-folding environment within cells and their organelles is responsible for the low efficiency and stochasticity of reprogramming. We find that the unfolded protein response of the endoplasmic reticulum (UPR〈sup〉ER〈/sup〉), the mitochondrial UPR, and the heat shock response, which ensure proteome quality during stress, are activated during reprogramming. The UPR〈sup〉ER〈/sup〉 is particularly crucial, and its ectopic, transient activation, genetically or pharmacologically, enhances reprogramming. Last, stochastic activation of the UPR〈sup〉ER〈/sup〉 predicts reprogramming efficiency in naïve cells. Thus, the low efficiency and stochasticity of cellular reprogramming are due partly to the inability to properly initiate the UPR〈sup〉ER〈/sup〉 to remodel the ER and its proteome.〈/p〉
    Electronic ISSN: 2375-2548
    Topics: Natural Sciences in General
    Published by American Association for the Advancement of Science (AAAS)
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