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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pharmaceutical research 13 (1996), S. 1411-1416 
    ISSN: 1573-904X
    Keywords: atomic force microscopy ; solid lipid nanoparticles ; controlled drug delivery ; prednisolone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. Solid Lipid Nanoparticles (SLN) are an alternative carrier system for the controlled delivery of drugs. In most cases prednisolone loaded SLN show a biphasic release behaviour. The initial phase is characterised by a fast drug release, which is followed by a sustained drug release over several weeks. Methods. The particles are produced by high pressure homogenisation of a lipid (e.g. compritol, cholesterol) dispersed in an aqueous surfactant solution. In this study atomic force microscopy was used to image the original unaltered shape and surface properties of the particles. The crystallinity of the nanoparticles was investigated by differential scanning calorimetry. Results. The AFM investigations revealed the disc like shape of the particles. From differential scanning calorimetry data it can be concluded that the particle core is in the crystalline state. Additionally it was proven that the particles are surrounded by a soft layer. Conclusions. Thus it is conceivable that the fast initial drug release during in vitro dissolution tests takes place by drug release of the outer non-crystalline layers of the particles. The following sustained drug release can be assigned to the predisolone release of the inner crystalline particle layers.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European biophysics journal 7 (1981), S. 321-321 
    ISSN: 1432-1017
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Economics Letters 3 (1979), S. 327-332 
    ISSN: 0165-1765
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Economics Letters 5 (1980), S. 21-27 
    ISSN: 0165-1765
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 1 (1953), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: The article is based on data from 74 seismic well velocity surveys in N.W. Germany.The effect of overburden is illustrated by means of diagrams representing interval velocities against depth. To eliminate observational errors and lithological variations from well to well, interval velocities from about the same depth are averaged. Thus, relatively uniform curves are obtained for lower Tertiary, Upper Cretaceous, and Lower Cretaceous (Albian), making the effect of overburden better evident than from individual observations. The vertical gradient of velocity for these geological sections are given. Furthermore, they are compared with curves for Lower Tertiary and Cretaceous obtained in N. America. Due to its high lime content, the Upper Cretaceous of N.W. Germany has a much higher velocity than that observed in the Cretaceous of N. America. The curves for shales of the Lower Tertiary and Lower Cretaceous (Albian), however, are similar in both countries. In older formations, on the other hand, e.g. Jurassic and Triassic, lithologic character has the dominant influence and the effect of overburden is rather small and often scarcely noticeable.The data considered cover a depth range down to 2,700 meters. The interval velocities are generally based on the use of various equal intervals.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    European journal of soil science 47 (1996), S. 0 
    ISSN: 1365-2389
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: A multidomain goethite was analysed with atomic force microscopy (AFM) to obtain information about the size and shape of pores on the surface, which are important for sorption processes of cations and anions. Wedge-shaped pores 〉 100 nm long at the surface occurred at the domain boundaries. They were 20-30 nm wide, becoming narrower towards the interior of the crystals to 2 nm and less. The AFM showed these pores to be at least 4–6 nm deep. The shape of the pores suggests that smaller pores continue much further into the interior of the crystals. Besides the irregularities between domains, randomly distributed steps of 〈 1 nm occurred. Hydrothermal treatment did not change crystal size, but made the surfaces smoother and reduced both the size and number of the pores and also the BET surface area (from 75.3 to 35.1 m2 g−1). The existence of meso- (2–30 nm width) and micropores (〈 2 nm width) in goethite crystals explains the slow diffusion of heavy metals, phosphate and other ions into goethite particles. Therefore, the external and internal surfaces of goethite crystals and their spatial heterogeneity have to be taken into account in models of ion adsorption by goethite.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Monetary Economics 10 (1982), S. 215-237 
    ISSN: 0304-3932
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Economics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  The clonal rat calvaria cell line RCJ3.1C5.18 (RCJ) undergoes chondrogenic differentiation after long-term culture post confluence. To allow flexible genetic manipulation, a tetracycline-regulated gene expression system was established in this cell line. Treatment with tetracycline in operational doses does not affect the differentiation of RCJ cells with respect to the markers tested. After stable transfection with pUHD15.1 containing the tetracycline transactivator (tTA) in the presence of pTK-hyg for hygromycin selection, 28 clones were isolated and characterized for alcian blue staining of cartilage-specific proteoglycans and for collagen type II expression. Clone R-tTA-24 was selected on the basis of phenotype and displayed tetracycline-dependent downregulation of luciferase activity (tet-OFF system) by two orders of magnitude (57–149-fold) after stable transfection with the reporter gene pBI-EGFP/luc. The novel, chondrogenic cell line R-tTA-24 may be stably transfected with various genes of interest for tetracycline- regulated gene expression using neomycin selection and may be a valuable tool to study the process of chondrogenic differentiation in vitro.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 1 (1964), S. 163-169 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    International journal of earth sciences 31 (1940), S. 594-633 
    ISSN: 1437-3262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Type of Medium: Electronic Resource
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