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  • 1
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A range of biomimetic analogues of the nicotinamide nucleotide coenzymes NAD(P)(H) have been developed based on the structure of a triazine dye template. These biomimetic redox coenzymes are relatively straightforward and inexpensive to synthesise and display NAD+-like activity with different dehydrogenases, despite their apparently minimal structural similarity to the native coenzyme NAD+. Horse liver alcohol dehydrogenase oxidises butan-1-ol, using the most active biomimetic coenzyme (Nap 1), with a k cat value an order of magnitude lower and a K m for the coenzyme two orders of magnitude higher than those using native NAD+. The enzymatically reduced biomimetic coenzymes may be reoxidised by phenazine methosulfate. We believe that these coenzymes may find applications in biotransformations and biosensors, and in the development of biomimetic catalysts where the redox enzyme itself is replaced by a synthetic binding site.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: Known mineral occurrences in northern Vancouver Island are typically hosted in volcanic units of the Bonanza Group. At a local scale, the mineralization is associated with advanced argillic bedrock alteration and is often intimately related to porphyry intrusions. On a larger scale, faults are thought to exert the most significant control on the distribution of mineralized host rocks. Poor exposures and a complex glacial history limit the use of traditional methods of geological mapping and mineral exploration in this region and to date geophysical methods have been under-utilized. Here we present findings from four standard geophysical (gravity, magnetics, electromagnetics and seismic refraction) methods, recently deployed here to elucidate the subsurface geology, as well as to identify new targets for base metal exploration.Results at two different sites show that the integrated interpretation of geophysical data, constrained by physical rock property measurements, yields detailed images of the subsurface at a fraction of the cost of drilling. At one site, east of Rupert Inlet, the final subsurface model shows that the Bonanza Group is not nearly as extensive as previously presumed. An extension of the Holberg Fault is identified some 50 km east of the visibly mapped outcrop and an extensive zone of alteration around the fault is recognized. Furthermore, a number of the methods provide support for the existence of a porphyry dike at this site. At the second site, north of Rupert Inlet, magnetic and electromagnetic data prove effective at mapping alteration and locating shear zones beneath a relatively thin drift cover. Together, these results help outline a strategy for exploration in drift-covered terrains and show that a redirection of exploration effort is warranted in the case of northern Vancouver Island.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0827
    Keywords: Bone resorption ; Glucocorticoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Chronic glucocorticoid excess is associated with the development of osteoporosis and, in human subjects, there is histomorphometric evidence of increased bone resorption. Paradoxically, most in vitro studies have suggested that glucocorticoids inhibit bone resorption but recently two groups have demonstrated increased osteolysis in glucocorticoid-treated bone organ cultures. The present study reexamines the effect of cortisol on basal bone resorption in neonatal mouse calvaria with particular emphasis on the effect of serum supplementation of the media. In the absence of serum, 45Ca release was significantly stimulated by 10-7 M cortisol (treatment/control 1.37+-0.06, P〈0.005) and by 10-6 M cortisol (treatment/control 1.27+-0.08, P〈0.005). The stimulation of resorption by 10-7 M hydrocortisone was progressive from 24 to 96 hours of incubation. In contrast, when calvaria were incubated in the presence of 5% serum, bone resorption was not increased by cortisol (10-8 M-10-6 M). In the presence of 5% charcoal-stripped, heat-inactivated serum, there was a small stimulation of 45Ca release at 10-6 M hydrocortisone only (treatment/control 1.19 +-0.06, P〈0.01). Incubation of bones with indomethacin did not modify the effect of cortisol in either the presence or absence of serum. In serum-free conditions, cortisol 10-8 M significantly inhibited the rate of thymidine incorporation, though at higher concentrations this effect was not seen. Cortisol produced a dose-related inhibition of serumstimulated thymidine incorporation. It is concluded that the presence of serum substantially modifies the effect of cortisol on basal bone resorption. The cortisol-induced stimulation of bone resorption which is seen in serum-free conditions is sustained over time and is not mediated by alterations in prostaglandin synthesis.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-136X
    Keywords: Metabolic rate ; Oxygen consumption ; Gilamonster ; Beaded lizard ; Heloderma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We measured metabolic rates at 15 and 25°C in 42 helodermatid lizards ranging in mass from 26 to 1616 g. No consistent repeatable daily rhythms of metabolism were detected. There were no significant differences in metabolic rates between the two species of Heloderma. The temperature coefficient for metabolism (Q 10) was 3.0 between 15 and 25°C. The mass exponent for helodermatids (0.69) differed significantly from the among-species mass exponent of 0.80 for all squamates combined. However, adult Heloderma had a mass exponent of 0.80. Rates of metabolism of adult helodermatids were lower than those of other squamate reptiles, and at 15°C periods of apnea contributed to a further reduction in metabolic rate. Our finding that helodermatids have low SMRs supports the hypothesis that ecology is important in influencing metabolic rate, and that “reclusive” squamates have lower rates of metabolism than do nonreclusive species.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Bradford : Emerald
    British food journal 100 (1998), S. 133-140 
    ISSN: 0007-070X
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: There is widespread concern that children consume too few fruit and vegetables and as a result are likely to incur health problems. This paper outlines a series of studies in which an intervention that combines video-based peer modelling with rewards has been shown to be very effective in enabling children to eat a variety of fruit and vegetables that previously they rejected. These effects have been very substantial and long lasting. The procedure has been used successfully in children's own homes and, as this paper shows in particular detail, in school settings.
    Type of Medium: Electronic Resource
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  • 6
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    Baltimore : Periodicals Archive Online (PAO)
    Human Biology. 23:1 (1951:Feb.) 41 
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 12 (1940), S. 229-231 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 13 (1941), S. 809-810 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial and engineering chemistry 9 (1937), S. 430-431 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 0034-6659
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Commissioned by the Ministry of Agriculture, Fisheries and Food, the Department of Health and carried out by Social and Community Planning Research and MRC Dunn Nutrition Unit, the dental hospitals of the Universities of Newcastle and Birmingham and the Department of Epidemiology of the University of London, this research forms part of the National Diet and Nutrition Survey. Set up in 1992 the surveys cover representative groups of the population and examine the diet of the over-65s in terms of actual dietary intake, habits, energy and nutrient intakes, physical measurements. Regional and socio-economic comparisons are made.
    Type of Medium: Electronic Resource
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