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  • 1
    Electronic Resource
    Electronic Resource
    Effect of morphine and acetylcholine on contractile activity and cyclic AMP in guinea-pig ileum (1990)
    Springer
    Bioscience reports 10 (1990), S. 113-119 
    Details
    ISSN: 1573-4935
    Keywords: cAMP ; acetylcholine ; morphine ; guinea-pig ileum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Neither acute nor prolonged exposure to morphine altered cAMP content or spontaneous movements of longitudinal muscle-myenteric plexus strips of the guinea-pig ileum. By contrast, exogenous acetylcholine or electrical stimulation of the strips elicited both a decrease of cAMP concentration and a twitch response. Atropine blocked the effects of stimulation on these parameters. Addition of morphine to electrically stimulated strips inhibited the twitch response but did not affect cAMP levels. Incubation with morphine led to the development of tolerance to the inhibitory effect on twitch activity and prevented the fall in cAMP normally elicited by electrical stimulation. These results suggest that muscarinic activation is associated with a reduction of cAMP content, an effect which would be impaired in opiate-tolerant tissues.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116859
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of haloperidol withdrawal on somatostatin level and binding in rat brain (1990)
    Springer
    Bioscience reports 10 (1990), S. 15-22 
    Details
    ISSN: 1573-4935
    Keywords: somatostatin receptors ; haloperidol withdrawal ; frontoparietal cortex ; hippocampus ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The effects of withdrawal on the level and specific binding of somatostatin in the frontoparietal cortex and hippocampus of the rat after chronic haloperidol treatment were examined using125I-Tyr11 somatostatin as tracer. One week after haloperiodol withdrawal the number of specific somatostatin receptors in both brain areas returned to control values, after having decreased as the result of chronic administration. Neither administration of haloperidol nor withdrawal of it affected the levels of somatostatin-like immunoreactivity (SLI) in the two brain areas studied. The return of the somatostatin receptor number to control values after haloperidol withdrawal may be related to the motor side-effects that are clinically observed when the haloperidol treatment is terminated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01116846
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of alloxan-induced diabetes on somatostatin binding to cytosolic components of rabbit gastric fundic mucosa (1988)
    Springer
    Bioscience reports 8 (1988), S. 233-240 
    Details
    ISSN: 1573-4935
    Keywords: somatostatin binding ; gastric mucosa ; alloxan ; diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Diabetes was induced by administration of alloxan (150 mg/Kg) to 24 h-fasted rabbits. Somatostatinlike immunoreactivity (SLI) and cytosolic binding sites for somatostatin in gastric fundic mucosa were studied using radiolabelled Tyr11-somatostatin. Three months after the onset of the disease, the specific binding of somatostatin to these sites was seen to be significantly lower, due to a reduction in the number (but not the affinity) of specific somatostatin binding sites of high-affinity and a disappearance of the specific, somatostatin binding sites of low-affinity. These changes were associated with an increase in the SLI concentration in both gastric fundic mucosa and plasma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01115040
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