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  • 1
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    Next-generation transgenic mice for optogenetic analysis of neural circuits (2014)
    Frontiers Media
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    Publication Date: 2022-05-25
    Description: © The Author(s), 2013. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Frontiers in Neural Circuits 7 (2013): 160, doi:10.3389/fncir.2013.00160.
    Description: Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. These mice express optogenetic probes, such as enhanced halorhodopsin or several different versions of channelrhodopsins, behind various neuron-specific promoters. These mice permit photoinhibition or photostimulation both in vitro and in vivo. Our results also reveal the important influence of fluorescent tags on optogenetic probe expression and function in transgenic mice.
    Description: This work was supported by a CRP grant from the National Research Foundation of Singapore and by the World Class Institute (WCI )Program of the National Research Foundation of Korea (NRF )funded by the Ministry of Education, Science and Technology of Korea (MEST) (NRF Grant Number: WCI2009-003).
    Keywords: Optogenetics ; Channelrhodopsin ; Photostimulation ; Photoinhibition ; Cerebellum ; Cortex ; Hippocampus ; Pons
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
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    Defining a critical period for inhibitory circuits within the somatosensory cortex (2017)
    Nature Publishing Group
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    Publication Date: 2022-05-25
    Description: © The Author(s), 2017. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 7 (2017): 7271, doi:10.1038/s41598-017-07400-8.
    Description: Although experience-dependent changes in brain inhibitory circuits are thought to play a key role during the “critical period” of brain development, the nature and timing of these changes are poorly understood. We examined the role of sensory experience in sculpting an inhibitory circuit in the primary somatosensory cortex (S1) of mice by using optogenetics to map the connections between parvalbumin (PV) expressing interneurons and layer 2/3 pyramidal cells. Unilateral whisker deprivation decreased the strength and spatial range of inhibitory input provided to pyramidal neurons by PV interneurons in layers 2/3, 4 and 5. By varying the time when sensory input was removed, we determined that the critical period closes around postnatal day 14. This yields the first precise time course of critical period plasticity for an inhibitory circuit.
    Description: This work was supported by a fellowship from NUS to SQL, A*STAR intramural funding for the Integrative Neuroscience Programme, Singapore Institute for Clinical Sciences for JCGS, and a Competitive Research Programme (CRP) grant from the National Research Foundation of Singapore (NRF Grant Number 2008 NRF-CRP 002-082).
    Repository Name: Woods Hole Open Access Server
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  • 3
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    All-optical mapping of barrel cortex circuits based on simultaneous voltage-sensitive dye imaging and channelrhodopsin-mediated photostimulation (2015)
    SPIE
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    Publication Date: 2022-05-25
    Description: © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Neurophotonics 2 (2015): 021013, doi:10.1117/1.NPh.2.2.021013.
    Description: We describe an experimental approach that uses light to both control and detect neuronal activity in mouse barrel cortex slices: blue light patterned by a digital micromirror array system allowed us to photostimulate specific layers and columns, while a red-shifted voltage-sensitive dye was used to map out large-scale circuit activity. We demonstrate that such all-optical mapping can interrogate various circuits in somatosensory cortex by sequentially activating different layers and columns. Further, mapping in slices from whisker-deprived mice demonstrated that chronic sensory deprivation did not significantly alter feedforward inhibition driven by layer 5 pyramidal neurons. Further development of voltage-sensitive optical probes should allow this all-optical mapping approach to become an important and high-throughput tool for mapping circuit interactions in the brain.
    Description: This work was supported by the World Class Institute (WCI) program of the National Research Foundation of Korea (NRF) funded by Ministry of Education, Science and Technology of Korea (MEST) (NRF) Grant No. WCI 2009-003 and by the Competitive Research Programme (CRP) of NRF (Singapore) Grant No. NRF 2008 NRF-CRP 002-082.
    Repository Name: Woods Hole Open Access Server
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  • 4
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    Defining a critical period for inhibitory circuits within the somatosensory cortex (2017)
    Springer Nature
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    Publication Date: 2017-08-04
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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