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  • 1
    Electronic Resource
    Electronic Resource
    Cytochemical studies on cytoplasmic granular elements in the hamster pineal gland (1979)
    Springer
    Histochemistry and cell biology 61 (1979), S. 177-187 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The pineal gland of adult golden hamsters (Mesocricetus auratus) was studied by various cytochemical methods at the electron microscopic level: (1) the modified chromaffin reaction specific for 5-hydroxytryptamine (5-HT), (2) argentaffin reaction, (3) zinc-iodide-osmium (ZIO) mixture reaction and (4) acid phosphatase reaction. In the pinealocytes, the dense-cored vesicles (80–160 nm in diameter) show both chromaffinity and argentaffinity, while the population of dense bodies (150–400 nm in diameter) is reactive to ammoniacal silver solution and ZIO mixture but not to the modified chromaffin reaction. After incubation for demonstration of acid phosphatase activity, reaction products are localized in some, but not all, of the dense bodies, in some of the small vesicles in the Golgi region and in one or two inner Golgi saccules. In nerve fibers in the pineal gland, small granulated vesicles are also reactive to the modified chromaffin reaction and ZIO mixture. Based upon these cytochemical results the following conclusions have been reached: (1) dense cored vesicles in the pinealocytes and small granulated vesicles in the nerve fibers of the hamster pineal gland contain 5-HT, and (2) the population of dense bodies in the pinealocytes is heterogenous, some are lysosomes and the others are possibly the granules responsible for the secretion of pineal peptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496530
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  • 2
    Electronic Resource
    Electronic Resource
    Development of the ciliary complex and microtubules in the cells of rat subcommissural organ (1969)
    Springer
    Cell & tissue research 96 (1969), S. 186-205 
    Details
    ISSN: 1432-0878
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fine structure of the rat subcommissural organs from the late stages of gestation through the postnatal to the adult stages was studied with the electron microscope. Emphasis in this report is placed on the development of the cilium with its affiliated structures. With the progress of cytodifferentiation centrioles originally located in the Golgi region migrate to the cell apex, where each then serves as a basal body to form a cilium which has a 9+2 organization of substructures. Thus, each of the mature subcommissural cells is provided with two cilia of motile type. Satellites first appear on one side of the basal body at about 17 fetal days, rapidly increase in number with age, and finally surround the basal body, forming an elaborate latticework. In the perinatal period microtubules progressively increase in number in the distal cytoplasm, which concurrently elongates and forms a prominent projection in the brain ventricle. Closely associated with the microtubules are large clusters of dense granular masses with an undefined border, which bear a close resemblance to the dense masses appearing in the differentiating cells of respiratory epithelium and having been generally assumed to be the precursor substance for centriole replication. However, the mature subcommissural cells contain no centrioles other than the preexisting pair, each of which has organized a cilium. The dense masses in the subcommissural cells are presumed to be involved in the formation of the cytoplasmic microtubules instead of new centrioles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00338766
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  • 3
    Electronic Resource
    Electronic Resource
    Fine structural changes in the hamster pineal gland after blinding and superior cervical ganglionectomy (1975)
    Springer
    Cell & tissue research 158 (1975), S. 285-299 
    Details
    ISSN: 1432-0878
    Keywords: Pineal (Hamster) ; Blinding ; Sympathetic ganglia ; Endoplasmic reticulum ; Reproductive organs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Pineal glands of male hamsters 8 weeks after removal of both eyes or both superior cervical ganglia and those of untreated animals were studied by electron microscopy. In the blinded hamsters the reproductive organs were remarkably involuted, whereas the pinealocytes enlarged and were characterized by a tremendous hypertrophy of the smoothsurfaced endoplasmic reticulum, in the mesh of which some dense cored vesicles were distributed. In contrast the pinealocytes of ganglionectomized hamsters atrophied and were noted by a large number of lysosomes and sparsity of the agranular reticulum, the testes being significantly larger than the controls. The findings were interpreted to be compatible with the view that the pineal capability of producing antigonadal substance is augmented by blinding and is suppressed by cervical ganglionectomy due to the impairment of normal functioning of the pineal by denervation. It is assumed that the degree of development of the smooth endoplasmic reticulum in the pinealocyte is parallel to, and reflects that of the pineal activity. Probably the membranous organelle is involved in the elaboration of the pineal antigonadal substance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223827
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  • 4
    Electronic Resource
    Electronic Resource
    A dense-cored filamentous body in Leydig cells of the golden hamster (1979)
    Springer
    Cell & tissue research 201 (1979), S. 369-376 
    Details
    ISSN: 1432-0878
    Keywords: Leydig cells ; Filaments ; Golden hamster ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A unique cytoplasmic structure has been observed in Leydig cells of the golden hamster. It consists of a laminar core made up of electron dense material surrounded by a filamentous matrix of lower density, and is tentatively called a dense-cored filamentous body (DCFB). DCFBs vary in overall size and in configuration of the centrally disposed dense lamina. They are typically located in the vicinity of the centrosome and the Golgi complex. The body has no limiting membrane, and may be in contact with virtually every type of organelle. The DCFB is well developed in active Leydig cells, whereas it is small in the quiescent stage of the secretory cell. It is likely that the DCFB is a constant organelle in the hamster Leydig cell and may be involved in the physiological function of the Leydig cell, which remains to be specified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236997
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  • 5
    Electronic Resource
    Electronic Resource
    Electron microscopic and cytochemical studies of the mouse subcommissural organ (1973)
    Springer
    Cell & tissue research 139 (1973), S. 217-236 
    Details
    ISSN: 1432-0878
    Keywords: Subcommissural organ ; Mouse ; Mucopolysaccharides ; Acid phosphatase activities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In mice most of the ependymal cells of the subcommissural organ (SCO cells) are densely packed with dilated cisternae of the endoplasmic reticulum (ER) containing either finely granular or flocculent materials. The well developed supra-nuclear Golgi apparatus consists of stacks of flattened saccules and small vesicles; the two or three outer Golgi saccules are moderately dilated and exhibit numerous fenestrations; occasional profiles suggesting the budding of coated vesicles and formation of membrane-bound dense bodies from the ends of the innermost Golgi saccules are seen. A few coated vesicles and membrane-bound dense bodies of various sizes and shapes are also found in the Golgi region. The contents of the dilated ER cisternae are stained with periodic acid-silver methenamine techniques. In the Golgi complex the two or three inner saccules are stained as deeply as the dense bodies, and the outer saccules are only slightly stained. The stained contents of ER cisternae are more electron opaque than those of the outer but less opaque than those of the inner Golgi saccules and the dense bodies. Acid phosphatase activities are localized in the dense bodies, some of the coated vesicles in the Golgi region, and in the one or two inner Golgi saccules. On the basis of these results the following conclusions have been reached: (1) In mouse SCO cells the finely granular and the flocculent materials in the lumen of ER cisternae contain a complex carbohydrate(s) which is secreted into the ventricle to form Reissner's fiber; (2) the secretory substance is assumed to be synthesized by the ER and stored in its cisternae, and the Golgi apparatus might play only a minor role, if any, in the elaboration of the secretory material; (3) most of the dense bodies in the mouse SCO cells are lysosomal in nature instead of being so-called dark secretory granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00306523
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  • 6
    Electronic Resource
    Electronic Resource
    The fine structure of testicular interstitial cells in the adult golden hamster with special reference to seasonal changes (1977)
    Springer
    Cell & tissue research 183 (1977), S. 385-393 
    Details
    ISSN: 1432-0878
    Keywords: Testis ; Endoplasmic reticulum ; Golden hamster ; Macrophages ; Seasonal changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The fine structure of the testicular interstitium was studied in normal adult golden hamsters sacrificed in the reproductive season (spring and summer) and in the winter. The Leydig cells in the reproductively active testes contain abundant endoplasmic reticulum (ER) and numerous mitochondria. The ER occurs in the form of flattened cisternae and tubules, the former prevailing. The cisternae are extremely extensive and are partly granular and partly agranular, their ends being continuous with the tubular reticulum. Mitochondria intervening between the cisternae are closely associated with the agranular portions of the latter. Adjacent to the Golgi complex and continuous with the centrosome a unique filamentous body with a dense laminar core is often observed. In the regressive testes, the Leydig cells show a great reduction of cytoplasmic volume and a remarkable decline of the organelles, especially agranular tubules. The possible functional significance of the tubular and cisternal ER with the associated mitochondria is discussed in relation to the biosynthesis of androgens. Macrophages appear to constitute another important population of the interstitial cell clusters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220645
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  • 7
    Electronic Resource
    Electronic Resource
    The influence of activation, removal or denervation of the pineal on the fine structure of the Leydig cell and seminal vesicle epithelium in golden hamsters (1978)
    Springer
    Cell & tissue research 191 (1978), S. 367-378 
    Details
    ISSN: 1432-0878
    Keywords: Leydig cells ; Seminal vesicle ; Pineal gland ; Golden hamster ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fine structural changes of testicular interstitial cells of Leydig and secretory cells of seminal vesicles were studied in golden hamsters under different functional states of the pineal gland. Experiments were performed in the reproductive season (summer months). In the hamsters blinded for 8 weeks the testes and the seminal vesicles were markedly atrophic, and the Leydig cells and the secretory cells of seminal vesicles were extremely involuted. By contrast, both types of cells in the pinealectomized or superior cervical ganglionectomized hamsters exhibited cytological features suggestive of an enhanced secretory activity. This study shows that functional activity of Leydig cells as well as secretory cells of seminal vesicles in the hamster may be depressed or augmented by stimulating or inhibiting the pineal antigonadal function, respectively, without performing hypophysectomy or hormonal administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00219802
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  • 8
    Electronic Resource
    Electronic Resource
    A centrosomal inclusion (striped nebulous body) in pinealocytes of the golden hamster (1987)
    Springer
    Cell & tissue research 248 (1987), S. 257-265 
    Details
    ISSN: 1432-0878
    Keywords: Cellular inclusions ; Centrioles ; Striated fibrils ; Pinealocytes ; Golden hamster (Mesocricetus auratus)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Electron microscopy has revealed the presence of a special cytoplasmic body in the centrosomal area of pinealocytes of the golden hamster, Mesocricetus auratus. It consists of branching electron-dense ribbons embedded in a flocculent matrix of moderate electron density, and is tentatively named the ‘striped nebulous body’ (SNB). The dense ribbon usually appears as a thick band accompanied by a parallel thin one to one side. The SNB is not bounded by a membrane, and is roughly round or kidney-shaped. Closely associated with the SNB are centrioles, microtubular sheaves and striated fibrils, the latter two being centriolar derivatives. The observations suggest that the SNB might be formed by the amalgamation of these microtubular sheaves and striated fibrils. In golden hamsters, pinealocytes often have multiple centrioles and centriolar derivatives. The SNB of adult hamsters is seen in the pinealocytes of both sexes, irrespective of the season of the year and the activity of the pineal gland. The functional significance of this body remains to be studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218192
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  • 9
    Electronic Resource
    Electronic Resource
    Immunocytochemical demonstration of a lipid droplet-specific capsule in cultured Leydig cells of the golden hamsters (1996)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 63 (1996), S. 366-373 
    Details
    ISSN: 0730-2312
    Keywords: capsule ; lipid droplet ; Leydig cell ; monoclonal antibody ; immunocytochemistry ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: In this report, we provide direct evidence for the presence of a lipid droplet-associated capsule in hamster steroidogenic Leydig cells by using a monoclonal antibody A2. Leydig cells are characterized by containing many lipid droplets and having 3β-hydroxysteroid dehydrogenase activity. Immunofluorescence staining with this antibody demonstrated a rim or capsule surrounding the lipid droplets in Leydig cells, a pattern not seen with anti-vimentin antibody. Immunogold labelling confirmed ultrastructurally that antibody binding was distributed on the lipid droplet surface. In order to investigate the possible function of the capsule, we examined the morphological changes induced in the capsule following stimulation with LH or dibutyryl cAMP; the fluorescent intensity of the capsule was seen to gradually decrease, accompanied by a decrease in number and size of lipid droplets, and the response to both reagents was time- and concentration-dependent. We thus conclude that hormonal stimulation resulting in the detachment of certain capsular proteins from the surface of lipid droplets is mediated via the cAMP signaling pathway and may allow cholesterol ester hydrolytic enzyme direct access to its substrate in the lipid droplet. © 1996 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 10
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    The fine structure of testicular interstitial cells in the adult golden hamster with special reference to seasonal changes (1977)
    Springer
    Details
    Publication Date: 1977-09-01
    Print ISSN: 0302-766X
    Electronic ISSN: 1432-0878
    Topics: Biology , Medicine
    Published by Springer
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