ISSN:
1420-9071
Keywords:
T. cruzi
;
immunology
;
T. cruzi vaccination
;
DBA/2
;
actinomycin-D
;
immunosuppression
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The subcutaneous (s.c.) vaccination of DBA/2 mice with 4 weekly doses of 3×107 living metacyclic forms ofT. cruzi, Y strain, obtained from culture in axenic medium and treated for 24 h with actinomycin-D (50 μg/107 parasites), a drug that promotes an irreversible blockade of the parasite replication, do not induce any detectable degree of humoral and cellular immunosuppression as assessed by a) the production of anti-SRBC antibodies, b) the permanence of delayed cutaneous reaction toT. cruzi antigen, to PPD and DNCB and c) the degree of blastogenic transformation of spleen lymphocytes in the presence of the specific antigen.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01950179
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