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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 1197-1202 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-4986
    Keywords: ganglioside GD2 ; immunosuppressionin vivo ; mass spectrometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Shedding of neuroblastoma gangliosides is positively correlated with tumour progression in patients with neuroblastoma. In assessing the biological activity of these ganglioside molecules, we recently found that total human neuroblastoma gangliosides inhibit cellular immune responses. Here, we have studied the major neuroblastoma ganglioside, GD2. GD2 was purified by high performance liquid chromatography and structurally characterized by mass spectrometry. Immunoregulatory effects of GD2 in vivo were then determined in an established murine model. GD2 significantly downregulated the local cellular immune response to an allogeneic cell challenge; the usual increase in mass of the lymph node draining the injection site was reduced by 88%, from 1.52 to 0.19 mg (control versus GD2-treated mice;p〈0.01). In parallel, lymphocyte recovery from each node was also reduced from 2.4 to 1.2×106 cells, and lymphocyte DNA synthesis was reduced to half of the control level. These results show that certain shed tumour gangliosides, such as GD2, function as intercellular signalling molecules, downregulate the cellular immune response, and may thereby enhance tumour formation and progression.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2013. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 118 (2013): 6495–6510, doi:10.1002/2013JC009455.
    Description: Moored current measurements were made at one mooring site in the northern Gulf of Tonkin for about 1 year during 1988–1989. Analyses were performed to examine characteristics and variability of tidal and subtidal flows. Rotary spectra showed two peaks at diurnal and semidiurnal periods, with higher diurnal energy. Complex demodulations of diurnal and semidiurnal tidal currents indicated that the tidal current magnitudes varied significantly with seasons: more energetic in the stratified summer than in the vertically well-mixed winter. The observed subtidal currents were highly correlated with the surface wind in winter but not in summer; challenging the conceptual summertime anticyclonic circulation pattern derived using wind-driven homogenous circulation theory. The computed currents from a global ocean model were in good agreement with the observed currents. Similar to the current observations, the model-computed flow patterns were consistent with the conceptual wind-driven circulation pattern in winter but opposite in summer. Process-oriented experiments suggest that the summertime cyclonic circulation in the northern Gulf of Tonkin forms as a result of the combination of stratified wind-driven circulation and tidal-rectified inflow from Qiongzhou Strait. The interaction between the southwest monsoon and buoyancy-driven flow from Hong River can significantly intensify the cyclonic circulation near the surface, but its contribution to the vertically averaged flow of the cyclonic circulation is limited.
    Description: Y. Ding has been supported by the State Scholarship Fund from the China Scholarship Council. C. Chen serves as chief scientist for the International Center for Marine Studies, Shanghai Ocean University, and his contribution has been supported by the Program of Science and Technology Commission of Shanghai Municipality (09320503700). C. Chen serves as the Zi Jiang Scholar at the State Key Laboratory for Estuarine and Coastal Research (SKLEC) of East China Normal University (ECNU) and Visiting Professor at School of Marine Sciences, Sun Yat-Sen University. C. Chen would like to credit this research to these two universities. Z. Lai’s contribution is supported by NSFC project 41206005 and Sun Yat-Sen University 985 grant 42000–3281301. The development of Global-FVCOM was funded by the US National Science Foundation Office of Polar Programs through grants ARC0712903, ARC0732084, ARC0804029, and ARC1203393.
    Description: 2014-06-03
    Keywords: Current measurements ; Circulation ; Numerical modeling
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 4
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 119 (2014): 5289–5310, doi:10.1002/2014JC009931.
    Description: Synthesis analyses were performed to examine characteristics of tidal and subtidal currents at eight mooring sites deployed over the northern South China Sea (NSCS) continental shelf in the 2006–2007 and 2009–2010 winters. Rotary spectra and harmonic analysis results showed that observed tidal currents in the NSCS were dominated by baroclinic diurnal tides with phases varying both vertically and horizontally. This feature was supported by the CC-FVCOM results, which demonstrated that the diurnal tidal flow over this shelf was characterized by baroclinic Kelvin waves with vertical phase differences varying in different flow zones. The northeasterly wind-induced southwestward flow prevailed over the NSCS shelf during winter, with episodic appearances of mesoscale eddies and a bottom-intensified buoyancy-driven slope water intrusion. The moored current records captured a warm-core anticyclonic eddy, which originated from the southwestern coast of Taiwan and propagated southwestward along the slope consistent with a combination of β-plane and topographic Rossby waves. The eddy was surface-intensified with a swirl speed of 〉50 cm/s and a vertical scale of ∼400 m. In absence of eddies and onshore deep slope water intrusion, the observed southwestward flow was highly coherent with the northeasterly wind stress. Observations did not support the existence of the permanent wintertime South China Sea Warm Current (SCSWC). The definition of SCSWC, which was based mainly on thermal wind calculations with assumed level of no motion at the bottom, needs to be interpreted with caution since the observed circulation over the NSCS shelf in winter included both barotropic and baroclinic components.
    Description: R. Li was supported by the SOA 908 Special Project Foundation of China (908-01-ST07 and 908-01-BC10), the National High Tech Project Foundation (863) of China (2008AA09A401), the Administrator Foundation of South Branch, SOA (0683). The development of FVCOM was funded by the US NSF Office of Polar Programs through grants ARC0712903, ARC0732084, ARC0804029, and ARC1203393.
    Description: 2015-02-19
    Keywords: Mooring ; Circulation ; Eddy
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 5
    Publication Date: 2022-05-26
    Description: Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 119 (2014): 1445–1464, doi:10.1002/2013JC009351.
    Description: Surface drifters released in the central Red Sea during April 2010 detected a well-defined anticyclonic eddy around 23°N. This eddy was ∼45–60 km in radius, with a swirl speed up to ∼0.5 m/s. The eddy feature was also evident in monthly averaged sea surface height fields and in current profiles measured on a cross-isobath, shipboard CTD/ADCP survey around that region. The unstructured-grid, Finite-Volume Community Ocean Model (FVCOM) was configured for the Red Sea and process studies were conducted to establish the conditions necessary for the eddy to form and to establish its robustness. The model was capable of reproducing the observed anticyclonic eddy with the same location and size. Diagnosis of model results suggests that the eddy can be formed in a Red Sea that is subject to seasonally varying buoyancy forcing, with no wind, but that its location and structure are significantly altered by wind forcing, initial distribution of water stratification and southward coastal flow from the upstream area. Momentum analysis indicates that the flow field of the eddy was in geostrophic balance, with the baroclinic pressure gradient forcing about the same order of magnitude as the surface pressure gradient forcing.
    Description: This project was supported by the King Abdullah University of Science and Technology (KAUST). The development of Global-FVCOM was supported by NSF grants ARC0712903, ARC0732084, ARC0804029 and OCE-1203393. C. Chen’s contributions were also supported by the International Center for Marine Studies at Shanghai Ocean University through the ‘‘Shanghai Universities First-class Disciplines Project.’’ L. Pratt was also supported by National Science Foundation Grant OCE0927017.
    Description: 2014-08-25
    Keywords: Eddies in the Red Sea
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 6
    Publication Date: 2022-05-26
    Description: © The Author(s), 2021. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Dong, W., Feng, Y., Chen, C., Wu, Z., Xu, D., Li, S., Xu, Q., Wang, L., Beardsley, R. C., Lin, H., Li, R., Chen, J., & Li, J. Observational and modeling studies of oceanic responses and feedbacks to typhoons Hato and Mangkhut over the northern shelf of the South China Sea. Progress in Oceanography, 191, (2021): 102507, https://doi.org/10.1016/j.pocean.2020.102507.
    Description: Meteorological and oceanic responses to Typhoons Hato and Mangkhut were captured by storm-monitoring network buoys over the northern shelf of the South China Sea. With similar shelf-traversing trajectories, these two typhoons exhibited distinctly different features in storm-induced oceanic mixing and oceanic heat transfer through the air-sea interface. A well-defined cold wake was detected underneath the storm due to a rapid drop in sea surface temperature during the Hato crossing, but not during the Mangkhut crossing. Impacts of oceanic mixing on forming a storm-produced cold wake were associated with the pre-storm condition of water stratification. In addition to oceanic mixing produced through the diffusion process by shear and buoyancy turbulence productions, the short-time scale of mixing suggested convection/overturning may play a critical role in the rapid cooling at the sea surface. The importance of convection/overturning to mixing depended on the duration of atmospheric cooling above the sea surface-the longer the atmospheric cooling, the more significant effect on mixing. Including the oceanic mixed layer (OML) in the WRF model was capable of reproducing the observed storm-induced variations of wind and air pressure, but not the air and sea surface temperatures. Process-oriented numerical experiments with the OML models supported both observational and modeling findings. To simulate the storm-induced mixing in a coupled atmospheric and oceanic model, we need to improve the physics of vertical mixing with non-hydrostatic convection/overturning. Warming over the shelf is projected to have a more energetic influence on future typhoon intensities and trajectories.
    Description: This work was supported by the National Key Research and Development Programs of China with grant numbers 2018YFC-1406201; 2016YFA-0602700; 2018YFC-1506903; 2018YFC-1406205, and the National Sciences Foundation of China with grant number U1811464. S. Li was supported by the oversea Ph.D. fellowship from the China Scholarship Council (No. 1409010025) and Dr. Chen’s Montgomery Charter Chair graduate education funds at the University of Massachusetts-Dartmouth.
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  • 7
    Publication Date: 2020-07-01
    Print ISSN: 2468-0257
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Elsevier
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  • 8
    Publication Date: 2014-08-09
    Print ISSN: 0170-0839
    Electronic ISSN: 1436-2449
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Springer
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  • 9
    Publication Date: 2015-02-12
    Print ISSN: 0170-0839
    Electronic ISSN: 1436-2449
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Published by Springer
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  • 10
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