ISSN:
1434-193X
Keywords:
Macrocystidia cucumis
;
Cucumins
;
Hirsutanes
;
Sesquiterpenoids
;
Antibiotics
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Arthrosporone (1) and eight new triquinane-type sesquiterpenoids have been isolated from mycelial cultures of the agaric Macrocystidia cucumis. The cucumins A-D (2, 4-6) are highly unsaturated hirsutane derivatives, whereas the cucumins E-G (7-9) represent a new type of linear triquinanes. Cucumin H (10) is a new member of the ceratopicane group. The absolute configuration of cucumin F (8) was assigned by 1H-NMR analysis of the corresponding Mosher esters. Two further metabolites were identified as cyclo(phenylalanylprolyl) (12) and cyclo(leucylprolyl) (13). Cucumin A (2) exhibits antibacterial and cytotoxic activities.
Type of Medium:
Electronic Resource
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