Publication Date:
2016-05-12
Description:
The nucleation and growth mechanisms of B polymorph of L-histidine (L-his) in a water-ethanol system were determined based on the induction time measurements. The induction times were experimentally determined at different supersaturations. The experimental results of induction time were correlated using the models of mononuclear and polynuclear mechanisms. The results showed that the primary nucleation mechanism of B polymorph of L-his is identified as a polynuclear mechanism, and the growth mechanism is identified as two-dimensional nucleation-mediated growth. These mechanisms of B polymorph of L-his will be used to characterize the polymorphic transformations and the overall crystallization rate of L-his.
Print ISSN:
0930-7516
Electronic ISSN:
1521-4125
Topics:
Chemistry and Pharmacology
,
Process Engineering, Biotechnology, Nutrition Technology
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