We report on data from an oceanographic cruise, covering western, central and eastern parts of the Mediterranean Sea, on the French research vessel Tethys 2 in May 2015. This cruise was fully dedicated to the maintenance and the metrological verification of a biogeochemical observing system based on a fleet of BGC-Argo floats. During the cruise, a comprehensive dataset of parameters sensed by the autonomous network was collected. The measurements include ocean currents, seawater salinity and temperature, concentration of inorganic nutrients, of dissolved oxygen, and chlorophyll pigments. The analytical protocols and data processing methods are detailed, together with a first assessment of the calibration state for all the sensors deployed during the cruise. Data collected at stations are available under http://doi.org/10.17882/51678, data collected along ship track are available under http://doi.org/10.17882/51691.