ISSN:
1612-1112
Keywords:
Column liquid chromatography
;
Pirarubicin and metabolites
;
Anthracyclines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary A new and highly sensitive HPLC method for the simultaneous determination of pirarubicine (THP-doxorubicin) and its metabolites, adriamycin and adriamycinol, in human plasma, is described. Samples were treated by liquid-liquid extraction, the organic phase removed and the residue dissolved in methanol. Separation was on a Lichrocart Supersher RP 8 column, (250×4 mm) 4 μm, with a mobile phase of acetonitrile/methanol/formate-buffer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02278598
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