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  • 1
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    Cities and Flooding / Part 1 : A Guide to Integrated Urban Flood Risk Management for the 21st Century (2012)
    Washington, D. C. : The World Bank
    Details
    Keywords: cities ; climate change ; distaster risk management ; environmental buffers ; flooding ; urban development
    Description / Table of Contents: Urban flooding is a significant challenge which today increasingly confronts the residents of the expanding cities and towns of developing countries, as well as policymakers and national, regional and local government officials. The Global Handbook presents the state-of-the art in urban flood risk management in a thorough and user-friendly way. It serves as a primer in integrated urban flood risk management for technical specialists, decision-makers and other concerned stakeholders in the private and community sectors. It covers the causes, probability and impacts of floods; the measures that can be used to manage flood risk, balancing structural and non-structural solutions in an integrated fashion; and the means by which these measures can be financed and implemented, and their progress monitored and evaluated. The Handbook provides an operational guide on how most effectively to manage the risk of floods in rapidly urbanizing settings – and within the context of a changing climate.
    Pages: Online-Ressource (631 Seiten)
    ISBN: 9780821394779
    URL: http://issuu.com/world.bank.publications/docs/9780821388662
    Language: English
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    E-BOOK
  • 2
    Unknown
    Cities and Flooding / Part 2 : A Guide to Integrated Urban Flood Risk Management for the 21st Century (2012)
    Washington, D. C. : The World Bank
    Details
    Keywords: cities ; climate change ; distaster risk management ; environmental buffers ; flooding ; urban development
    Description / Table of Contents: Urban flooding is a significant challenge which today increasingly confronts the residents of the expanding cities and towns of developing countries, as well as policymakers and national, regional and local government officials. The Global Handbook presents the state-of-the art in urban flood risk management in a thorough and user-friendly way. It serves as a primer in integrated urban flood risk management for technical specialists, decision-makers and other concerned stakeholders in the private and community sectors. It covers the causes, probability and impacts of floods; the measures that can be used to manage flood risk, balancing structural and non-structural solutions in an integrated fashion; and the means by which these measures can be financed and implemented, and their progress monitored and evaluated.The Handbook provides an operational guide on how most effectively to manage the risk of floods in rapidly urbanizing settings – and within the context of a changing climate.
    Pages: Online-Ressource (631 Seiten)
    ISBN: 9780821394779
    URL: http://issuu.com/world.bank.publications/docs/9780821388662_part2
    Language: English
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  • 3
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    Population-scale proteome variation in human induced pluripotent stem cells (2020)
    eLife Sciences Publications
    Details
    Publication Date: 2020-08-10
    Description: Human disease phenotypes are driven primarily by alterations in protein expression and/or function. To date, relatively little is known about the variability of the human proteome in populations and how this relates to variability in mRNA expression and to disease loci. Here, we present the first comprehensive proteomic analysis of human induced pluripotent stem cells (iPSC), a key cell type for disease modelling, analysing 202 iPSC lines derived from 151 donors, with integrated transcriptome and genomic sequence data from the same lines. We characterised the major genetic and non-genetic determinants of proteome variation across iPSC lines and assessed key regulatory mechanisms affecting variation in protein abundance. We identified 654 protein quantitative trait loci (pQTLs) in iPSCs, including disease-linked variants in protein-coding sequences and variants with trans regulatory effects. These include pQTL linked to GWAS variants that cannot be detected at the mRNA level, highlighting the utility of dissecting pQTL at peptide level resolution.
    Electronic ISSN: 2050-084X
    Topics: Biology , Medicine , Natural Sciences in General
    Published by eLife Sciences Publications
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  • 4
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    Live-cell imaging RNAi screen identifies PP2A–B55α and importin-β1 as key mitotic exit regulators in human cells (2010)
    Details
    Publication Date: 2022-05-25
    Description: Author Posting. © The Authors, 2010. This is the author's version of the work. It is posted here by permission of Nature Publishing Group for personal use, not for redistribution. The definitive version was published in Nature Cell Biology 12 (2010): 886-893, doi:10.1038/ncb2092.
    Description: When vertebrate cells exit mitosis, they reorganize various cellular structures to build functional interphase cells1. This depends on Cdk1 inactivation and subsequent dephosphorylation of its substrates2-4. Members of PP1 and PP2A phosphatase families can dephosphorylate Cdk1 substrates in biochemical extracts during mitotic exit5, 6, but how this relates to postmitotic reassembly of interphase structures in intact cells is not known. Here, we used a live imaging assay to screen by RNAi a genome-wide library of protein phosphatases for mitotic exit functions in human cells. We identified a trimeric PP2A-B55α complex as a key factor for postmitotic reassembly of the nuclear envelope, the Golgi apparatus, and decondensed chromatin, as well as for mitotic spindle breakdown. Using a chemically-induced mitotic exit assay, we found that PP2A-B55α functions downstream of Cdk1 inactivation. PP2A-B55α isolated from mitotic cells had reduced phosphatase activity towards the Cdk1 substrate histone H1 and it was hyper-phosphorylated on all subunits. Mitotic PP2A complexes co-purified with the nuclear transport factor Importin β1, and RNAi depletion of Importin β1 delayed mitotic exit synergistically with PP2A-B55α. This demonstrates that PP2A-B55α and Importin β1 cooperate in the regulation of postmitotic assembly mechanisms in human cells.
    Description: This work was supported by SNF research grant 3100A0-114120, SNF ProDoc grant PDFMP3_124904, a European Young Investigator (EURYI) award of the European Science Foundation to DWG, and a MBL Summer Research Fellowship by the Evelyn and Melvin Spiegel Fund to DWG, a Roche Ph.D. fellowship to MHAS, and a Mueller fellowship of the Molecular Life Sciences Ph.D. program Zurich to MH. MH and MHAS are fellows of the Zurich Ph.D. Program in Molecular Life Sciences. VJ and JG were supported by grants of the ‘Geconcerteerde OnderzoeksActies’ of the Flemish government, the ‘Interuniversitary Attraction Poles’ of the Belgian Science Policy P6/28 and the ‘Fonds voor Wetenschappelijk Onderzoek-Vlaanderen’. AIL is a Wellcome Trust Principal Research Fellow. AAH acknowledges funding by the Max Planck Society, the EU-FP6 integrated project MitoCheck, and the BMBF grant DiGtoP [01GS0859]. Work in the groups of KM and JMP was supported by the EU-FP6 integrated project MitoCheck, Boehringer Ingelheim and by the GEN-AU programme of the Austrian Federal Ministry of Science and Research (Austrian Proteomics Platform III), by MeioSys within the Seventh Framework Programme of the European Commission, and by Chromosome Dynamics, which is funded by the Austrian Science Foundation (FWF).
    Repository Name: Woods Hole Open Access Server
    Type: Preprint
    Format: application/pdf
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    PAPER (OA)
  • 5
    Electronic Resource
    Electronic Resource
    The Use of Perchloric Acid in Propellants Analysis. (1963)
    s.l. : American Chemical Society
    Analytical chemistry 35 (1963), S. 1058-1060 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60201a040
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Metabolic complexity in the RNA world and implications for the origin of protein synthesis (1990)
    Springer
    Journal of molecular evolution 30 (1990), S. 7-15 
    Details
    ISSN: 1432-1432
    Keywords: Precellular evolution ; Genetic code for metabolism ; RNA adaptor-linked metabolites ; Origin of protein synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A model is presented for the evolution of metabolism and protein synthesis in a primitive, acellular RNA world. It has been argued previously that the ability to perform metabolic functions logically must have preceded the evolution of a message-dependent protein synthetic machinery and that considerable metabolic complexity was achieved by ribo-organisms (i.e., organisms in which both genome and enzymes are comprised of RNA). The model proposed here offers a mechanism to account for the gradual development of sophisticated metabolic activities by ribo-organisms and explains how such metabolic complexity would lead subsequently to the synthesis of genetically encoded polypeptides. RNA structures ancestral to modern ribosomes, here termed metabolosomes, are proposed to have functioned as organizing centers that coordinated, using base-pairing interactions, the order and nature of adaptor-mounted substrate/catalyst interactions in primitive metabolic pathways. In this way an ancient genetic code for metabolism is envisaged to have predated the specialized modern genetic code for protein synthesis. Thus, encoded amino acids initially would have been used, in conjunction with other encoded metabolites, as building blocks for biosynthetic pathways, a role that they retain in the metabolism of contemporary organisms. At a later stage the encoded amino acids would have been condensed together on similar RNA metabolosome structures to form the first genetically determined, and therefore biologically meaningful, polypeptides. On the basis of codon distributions in the modern genetic code it is argued that the first proteins to have been synthesized and used by ribo-organisms were predominantly hydrophobic and likely to have performed membrane-related functions (such as forming simple pore structures), activities essential for the evolution of membrane-enclosed cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02102448
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  • 7
    Electronic Resource
    Electronic Resource
    A matter of style: reconciling Henri and Henry (2004)
    Bingley : Emerald
    Management decision 42 (2004), S. 330-356 
    Details
    ISSN: 0025-1747
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: During the twentieth century, much of the discussion about managerial behaviour centred on the difference between management functions and manager roles, with much of the debate centring on "Who is right, Mintzberg or Fayol?" Reports on a study, involving 523 Australian managers, which suggests both are right - Fayol gave us management as we would like it to be and Mintzberg gave us management as it is. In doing so, promulgates a set of new constructions of managerial behaviour - preferred managerial style (management as we would like it to be) and enacted managerial style (management as it is). Taken together, we now have available to us a more integrated theoretical base for research on management and managerial behaviour, and a measure that can be used to progress the required research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00251740410513845
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  • 8
    Electronic Resource
    Electronic Resource
    On the value of management history: Absorbing the past to understand the present and inform the future (2005)
    Bingley : Emerald
    Management decision 43 (2005), S. 1273-1281 
    Details
    ISSN: 0025-1747
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Economics
    Notes: Purpose - The purpose of this paper is to consider the value of management history as a contributor to the development of the theory and practice of management and, to the extent that it is necessary to absorb the past in order to understand the present and inform the future, consider what happens to the knowledge base when the surviving "contributions" to the knowledge base are partial and, indeed, erroneous. Design/methodology/approach - The articles that constitute this special issue form the launching-pad for this discussion, with the ideas presented here combined with previous research and commentaries on the issues raised. Research limitations/implications - In The Life of Reason, Santayana said, "Those who cannot remember the past are condemned to repeat it". Managers looking for the "next big thing", without being able to incorporate it effectively into their experience, and the experience of those who are long gone, are condemned to repeat not just the past, but also the mistakes of the past. Accordingly, it is also critical for management scholars to both recognise and take advantage of earlier thinking and empirical work to inform their contemporary musings and research if they are to provide meaningful frameworks for practitioners. Originality/value - Drawing on the themes presented in the articles of this special issue, the paper demonstrates the value of knowing accurately the history of management thought to scholars and practitioners alike.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/00251740510634859
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  • 9
    Electronic Resource
    Electronic Resource
    The value of Quinn's competing values model in an Australian context (2003)
    Bradford : Emerald
    Journal of managerial psychology 18 (2003), S. 46-59 
    Details
    ISSN: 0268-3946
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Psychology , Economics
    Notes: A variety of measures of organizational culture have been proposed and one widely used in Australia is that based on Quinn's competing values model. To date, however, there has been no published research examining its validity and reliability when used with Australian organizations. This paper presents the results of a study of 462 managers' perceptions of their organizations and concludes that Quinn's measure is a useful one in an Australian context. It also suggests that Australian organizations may have cause to be concerned about the environments within which their employees operate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/02683940310459583
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  • 10
    Electronic Resource
    Electronic Resource
    Seasonal Differences in Ovulating Hormone in the Merino Ewe (1960)
    [s.l.] : Nature Publishing Group
    Nature 186 (1960), S. 971-972 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Merino ewes were injected daily with 10 mgm. of progesterone in oil intramuscularly for 14 days in either April (the middle of the breeding season) or October (ancestrus). At the same time as the final progesterone injection each ewe received 500 i.u. of pregnant mare serum gonadotrophin ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/186971b0
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