ALBERT

Description: Ferromanganese nodules were retrieved at different levels inside a core taken in the vicinity of the Hawaiian Islands. Total iron contents were determined by the bichromate method with reduction by a bismuth reducing agent. Mn total content was determined by the volumetric arsenite-nitrate method, MnO2 content was determined from the active oxygen, and the MnO content was the difference between Mn total and MnO2.

Description: CD4 T cells play a critical role in regulating CD8 T-cell responses during chronic viral infection. Several studies in animal models and humans have shown that the absence of CD4 T-cell help results in severe dysfunction of virus-specific CD8 T cells. However, whether function can be restored in already exhausted CD8 T cells by providing CD4 T-cell help at a later time remains unexplored. In this study, we used a mouse model of chronic lymphocytic choriomeningitis virus (LCMV) infection to address this question. Adoptive transfer of LCMV-specific CD4 T cells into chronically infected mice restored proliferation and cytokine production by exhausted virus-specific CD8 T cells and reduced viral burden. Although the transferred CD4 T cells were able to enhance function in exhausted CD8 T cells, these CD4 T cells expressed high levels of the programmed cell death (PD)-1 inhibitory receptor. Blockade of the PD-1 pathway increased the ability of transferred LCMV-specific CD4 T cells to produce effector cytokines, improved rescue of exhausted CD8 T cells, and resulted in a striking reduction in viral load. These results suggest that CD4 T-cell immunotherapy alone or in conjunction with blockade of inhibitory receptors may be a promising approach for treating CD8 T-cell dysfunction in chronic infections and cancer.

Description: With the integration of large-scale wind power plants (WPPs), there is more and more demand for peak regulation service, and the peak regulation cost is increasing too. Reasonable calculation of peak regulation service cost caused by wind power generation (WPG) is the premise of stimulating conventional units to provide peak regulation services. After introducing the concept of peak regulation service in China, the impact of WPG on peak regulation is analyzed, and a quantitative model of peak regulation cost caused by WPG is put forward form the view point of the value of unit output adjustment. An optimization model with paid peak regulation is established to analyze the impact of WPG on peak regulation costs. The proposed method is tested on a 10-thermal power units system with WPPs, and the results verify the effectiveness of the proposed method.

Description: Sorafenib ameliorates bleomycin-induced pulmonary fibrosis: potential roles in the inhibition of epithelial–mesenchymal transition and fibroblast activation Cell Death and Disease 4, e665 (June 2013). doi:10.1038/cddis.2013.154 Authors: Y-L Chen, X Zhang, J Bai, L Gai, X-L Ye, L Zhang, Q Xu, Y-X Zhang, L Xu, H-P Li & X Ding

Description: 〈span〉〈div〉Summary〈/div〉We recently found the original Omori seismograms recorded at Hongo, Tokyo, of the 1922 Atacama, Chile, earthquake (〈span〉MS 〈/span〉= 8.3) in the historical seismogram archive of the Earthquake Research Institute (ERI) of the University of Tokyo. These recordings enable a quantitative investigation of long-period seismic radiation from the 1922 earthquake. We document and provide interpretation of these seismograms together with a few other seismograms from Mizusawa, Japan, Uppsala, Sweden, Strasbourg, France, Zi-ka-wei, China, and De Bilt, Netherlands. The 1922 event is of significant historical interest concerning the cause of tsunami, discovery of G wave, and study of various seismic phase and first-motion data. Also, because of its spatial proximity to the 1943, 1995, and 2015 great earthquakes in Chile, the 1922 event provides useful information on similarity and variability of great earthquakes on a subduction-zone boundary. The 1922 source region, having previously ruptured in 1796 and 1819, is considered to have significant seismic hazard. The focus of this paper is to document the 1922 seismograms so that they can be used for further seismological studies on global subduction zones. Since the instrument constants of the Omori seismographs were only incompletely documented, we estimate them using the waveforms of the observed records, a calibration pulse recorded on the seismogram and the waveforms of better calibrated Uppsala Wiechert seismograms. Comparison of the Hongo Omori seismograms with those of the 1995 Antofagasta, Chile, earthquake (〈span〉M〈/span〉〈sub〉w 〈/sub〉= 8.0) and the 2015 Illapel, Chile, earthquake (〈span〉M〈/span〉〈sub〉w 〈/sub〉= 8.3) suggests that the 1922 event is similar to the 1995 and 2015 events in mechanism (i.e. on the plate boundary megathrust) and rupture characteristics (i.e. not a tsunami earthquake) with 〈span〉M〈/span〉〈sub〉w〈/sub〉 = 8.6 ± 0.25. However, the initial fine scale rupture process varies significantly from event to event. The G1 and G2, and R1 and R2 of the 1922 event are comparable in amplitude, suggesting a bilateral rupture, which is rare for large megathrust earthquakes.〈/span〉

Description: Aims Exploring flowering patterns and detecting processes are essential when probing into the nature of reproductive traits during the life history and the interactions among different evolutionary clades. Such patterns are believed to be influenced by many factors, but quantifying these impacts at the community-level remains poorly understood. Methods We investigated the flowering patterns based on long-term herbarium records in a given area from subtropical forest regions in southern China. We obtained 5258 herbarium voucher specimens collected from the Dinghushan National Nature Reserve (DNNR) belonging to 166 families, 943 genera and 2059 species and examined the month when each species was flowering during the period 1920–2007. Important Findings The results showed that plants flowered sequentially almost throughout the whole year, showing the characteristics of subtropical evergreen broad-leaved forests. Flowering spectrums of the entire flora and the four life forms exhibited a clear unimodality that is probably typical of subtropical forest communities. Flowering patterns of the DNNR were positively correlated with mean rainfall, mean air temperature and mean sunshine duration. Median flowering dates of the 38 large species-rich families ranged from early April to late August; 25 families exhibited significant unimodal distribution patterns, whereas the remaining families were unclear or bimodal. Median flowering dates of the 10 most species-rich genera ranged from middle May to later July. While the results are consistent with climatic factors playing a general role in flowering patterns, median flowering dates varied significantly among species-rich families and genera, suggesting that phylogenies could provide specific constraints in subtropical forests.

Description: Residual resistivity ratio (RRR) and thermal conductivity of metal matrix in metal/superconductor composite wires are important parameters for designing superconducting magnets. However, the resistivity of silver in reacted Ag/Bi-2212 wires has yet to be determined over temperature range from 4.2 K to 80 K because Bi-2212 filaments have a critical transition temperature T c of ∼ 80 K, and because it is unknown whether the RRR of Ag/Bi-2212 degrades with Cu diffusing from Bi-2212 filaments into silver sheathes at elevated temperatures and to what degree it varies with heat treatment. We measured the resistivity of stand-alone Ag and AgMg (Ag-0.2 wt.% Mg) wires as well as the resistivity of Ag and Ag-0.2 wt.% Mg in Ag/Bi- 2212 round wires reacted in 1 bar oxygen at 890 °C for 1, 8, 24 and 48 hours and quickly cooled to room temperature. The heat treatment was designed to reduce the critical current I c of Bi- 2212 wires to nearly zero while allowing Cu lo...

Description: We imaged the azimuthal anisotropy of Rayleigh wave phase velocity (10–60 s) in northeast North China Craton using the teleseismic data recorded by a dense temporary array, and then inverted for the 3-D azimuthal anisotropy of the crust and uppermost mantle (20–110 km). The results reveal that the azimuthal anisotropy varies both horizontally and vertically. Obvious stratified azimuthal anisotropy is shown in the Central Orogenic Belt, where the fast direction is NE–SW to NNE–SSW in the depth range of 20–40 km and changes to NW–SE to NWW–SEE in the depth range of 60–110 km. In the depth range of 30–40 km, a prominent low velocity belt is shown on the southwest of Zhangjiakou-Penglai fault zone (ZPFZ) and the fast direction is subparallel to the strike of the low velocity belt. Distinct lateral variations of azimuthal anisotropy are clearly shown at 110 km. Our results provide new evidence for the existence of upwelling asthenosphere beneath the Datong volcano and support the assumption that ZPFZ may act as the channel of upwelling asthenosphere. Historical strong earthquakes ( M ≥ 6.0) mainly occurred in the transition zone between low and high velocity anomalies in the upper and middle crust. The upwelling asthenosphere may prompt the generation of large earthquake.