Publication Date:
1999-11-13
Description:
An understanding of how T cell memory is maintained is crucial for the rational design of vaccines. Memory T cells were shown to persist indefinitely in major histocompatibility complex (MHC) class I-deficient mice and retained the ability to make rapid cytokine responses upon reencounter with antigen. In addition, memory CD8 T cells, unlike naive cells, divided without MHC-T cell receptor interactions. This "homeostatic" proliferation is likely to be important in maintaining memory T cell numbers in the periphery. Thus, after naive CD8 T cells differentiate into memory cells, they evolve an MHC class I-independent "life-style" and do not require further stimulation with specific or cross-reactive antigen for their maintenance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murali-Krishna, K -- Lau, L L -- Sambhara, S -- Lemonnier, F -- Altman, J -- Ahmed, R -- AI30048/AI/NIAID NIH HHS/ -- NS21496/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1999 Nov 12;286(5443):1377-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Emory Vaccine Center and Department of Microbiology and Immunology, Emory University, Atlanta, GA 30322, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10558996" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
Antigens, CD44/analysis
;
Antigens, Viral/immunology
;
CD8-Positive T-Lymphocytes/cytology/*immunology
;
Cell Division
;
Epitopes/immunology
;
Histocompatibility Antigens Class I/*immunology
;
Homeostasis
;
*Immunologic Memory
;
Interferon-gamma/biosynthesis
;
Lymphocytic Choriomeningitis/immunology
;
Lymphocytic choriomeningitis virus/*immunology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Radiation Chimera
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocyte Subsets/cytology/*immunology
;
beta 2-Microglobulin/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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