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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 15 (1981), S. 57-89 
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 57 (1977), S. 167-169 
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Genetics 25 (1991), S. 339-359 
    ISSN: 0066-4197
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 17 (1969), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 19 (1981), S. 292-292 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 26 (1953), S. 10-15 
    ISSN: 1420-9136
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Description / Table of Contents: Summary The Fermat's principle states that a given ray of waves follows a particular path so that it travels from a given point to a second point in a minimum amount of time. In geometrical optics the basic laws of refraction and reflexion are a consequence of this principle. In homogeneous media the raypaths are straight lines. In inhomogeneous media (as it is the case in seismic prospecting) the raypaths are curved lines. The solutions of these problems take place with integral calculus (variational calculus). — Also in astronomy exist similar problems like in seismic prospecting. The path which a lightray follows in “concave world” leads likewise to a problem of variational calculus. — In the case of a linear increasing in velocity with the depth of waves, the raypaths are circles. — If velocity increases linear with the distance from a centre the raypaths are spirals. — In “concave world” the velocity is proportional to the square of the distance from a centrepoint and not linear, as an other author supposed it. That follows out of the circular raypaths. — It is stated that in case of the circular paths of lightrays in “concave world” the centre is an uncertainty. Here are no definit paths of lightrays. This deficiency can be eliminated by absuming a sphere around the centre on the surface of which the raypaths end. The equation for this case is determinated.
    Notes: Zusammenfassung Der Lichtstrahlengang der Hohlwelt führt auf bekannte seismische Probleme, die Mittels der Variationsrechnung gelöst werden. Die Wellengeschwindigkeit im Hohlweltmodell ist bei kreisförmigen Lichtwegen nicht linear, wie bisher irrtümlich angenommen wurde, sondern quadratisch von der Entfernung vom Zentrum abhängig. Die Formel der Hohlweltoptik, welche die Singularität im Weltzentrum vermeidet, wird aufgestellt.
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  • 7
    ISSN: 1432-0983
    Keywords: Antimutator ; DDR48 ; Saccharomyces cerevisiae ; Spontaneous mutation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The antimutator phenotype, reportedly conferred by disruption of the Saccharomyces cerevisiae DDR48 gene, was suggested to affect only a specific spontaneous mutational pathway. We attempted to identify the types of mutation that are DDR48-dependent by determining the specificity of the ddr48 antimutator. However, disruption of DDR48 did not decrease the rates of spontaneous forward mutation in a plasmid-borne copy of the yeast SUP4-o gene, the reversion or suppression of the lys2–1 allele, or forward mutation at the CAN1 locus. Interestingly, the latter gene had been reported previously to be subject to the antimutator effect. DNA sequence analysis of spontaneous SUP4-o mutations arising in DDR48 and ddr48 backgrounds provided no evidence for a reduction in the rates of individual mutational classes. Thus, we were unable to verify that disruption of DDR48 causes an antimutator phenotype.
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  • 8
    ISSN: 1432-0983
    Keywords: dTMP starvation ; Sister chromatid recombination ; rad mutants
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Inhibition of thymidylate biosynthesis has been found to induce deletion of a LEU2 insert from the ribosomal DNA gene cluster of haploid strains of Saccharomyces cerevisiae. Loss of the insert was detected phenotypically by the enhanced production of both sectored (leu+/leu−) and non-sectored (leu−) colonies. Hybridization patterns obtained by Southern blot analysis of DNA from the leu+ and leu− sectors were consistent with the occurrence of unequal sister chromatid recombination. The induction of sectored colonies was prevented by the rad52-1 mutation but not by defects in RAD6. However, the formation of non-sectored leu− colonies was induced by thymidylate depletion in both rad52-1 and rad6 strains.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0983
    Keywords: Key words Heteroduplex repair ; Strand discrimina-tion ; Strand interruptions ; Saccharomyces cerevisiae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Site-directed mutagenesis was used to construct yeast centromere plasmids in which a strand nick or gap could be placed 5′ or 3′, on either strand, to a reporter gene (SUP4-o) carrying defined base mismatches. The plasmids were then transformed into yeast cells and the direction and efficiency of mismatch repair were assayed by scoring colouring of the transformant colonies. Strands that were nicked were consistently corrected more often than intact strands, but the effect was very small. However, placement of a small gap at the same positions as the nicks resulted in a marked increase in selection for the gapped strand and an enhanced efficiency of mismatch repair. Both the preference for the gapped strand and correction of the mismatch were offset by deletion of the mismatch repair gene PMS1. Together, the results suggest that strand interruptions can direct intracellular mismatch correction of plasmid-borne base mispairs in yeast.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nutrition 33 (1994), S. 120-127 
    ISSN: 1436-6215
    Keywords: Gicht ; Nahrung ; Purinabbau ; Mikroorganismen ; Gout ; nutrition ; purine degradation ; microorganisms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary 27 microorganisms were tested for their ability to degrade extracellular purines as sole sources of carbon, nitrogen, and energy. Beside adenine, guanine, xanthine, hypoxanthine, and urate as free purine bases, this test included 5′-AMP, 5′-GMP, 5′-XMP, and 5′-IMP, as well as DNA and RNA as purine compounds. Generally, only a limited number of microbial species was capable of metabolizing the substances named above. Compared to the other species,Paracoccus denitrificans showed the greatest substrate spectrum, including the free bases as well as the mononucleotides. However, the polymers DNA and RNA were not degraded.
    Notes: Zusammenfassung 27 Mikroorganismen wurden auf ihre Fähigkeit zum Abbau extrazellulärer Purine als alleinige Kohlenstoff-, Stickstoff- und Energiequellen untersucht. Dieser Test umfaßte neben den freien Purinbasen Adenin, Guanin, Xanthin, Hypoxanthin und Urat deren Verbindungen 5′-AMP, 5′-GMP, 5′-XMP und 5′-IMP sowie DNA und RNA. Allgemein betrachtet war nur eine begrenzte Zahl von Mikroorganismen zur Metabolisierung der genannten Substanzen befähigt. Im Vergleich mit den übrigen Spezies wiesParacoccus denitrificans das größte Substratspektrum auf, das sowohl die freien Basen als auch die Mononukleotide umfaßte. Die Polymere DNA und RNA wurden jedoch nicht abgebaut.
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