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  • 1
    Electronic Resource
    Electronic Resource
    Ocular complications of the acquired immunodeficiency syndrome (1993)
    Springer
    Pharmacy world & science 15 (1993), S. 56-67 
    Details
    ISSN: 1573-739X
    Keywords: AIDS ; Cytomegaloviruses ; Drug therapy ; Foscarnet ; Ganciclovir ; HIV infection ; Retinitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The most common ocular complication in patients with the acquired immunodeficiency syndrome (AIDS) is cytomegalovirus retinitis. Incidence figures vary from 20 to 76%. Patients with cytomegalovirus may suffer from mild visual impairment of one or both eyes, but as the disease progresses the retinitis will almost certainly lead to blindness. Although cytomegalovirus retinitis is not a life-threatening infection, it can largely diminish the patient's quality of life. Clinical trials for the treatment of cytomegalovirus retinitis with a number of antiviral drugs have resulted in two drugs of choice, ganciclovir and foscarnet. Both drugs have an initial efficacy with induction therapy of 80–90%, but maintenance therapy is always needed to prevent a relapse. To exclude systemic side-effects of ganciclovir, intravitreal administration has been investigated with good results. Combination therapy of foscarnet and ganciclovir may be worthwhile in resistant cytomegalovirus retinitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01874084
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  • 2
    Electronic Resource
    Electronic Resource
    Didanosine, a new antiretroviral drug (1992)
    Springer
    Pharmacy world & science 14 (1992), S. 297-304 
    Details
    ISSN: 1573-739X
    Keywords: Biochemistry ; Didanosine ; Drug evaluation ; Pharmacokinetics ; Pharmacology ; Side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In this article the literature about didanosine, an antiretroviral drug, is reviewed. The mechanism of action, biochemical pharmacology, pharmacokinetics, and clinical results of phase-I trials are discussed. Serious adverse effects such as pancreatitis and peripheral neuropathy have occurred in these trials. An antiretroviral effect was observed in terms of an increase in CD4+ lymphocytes and a decrease in p24 antigen levels in HIV-infected individuals. Didanosine seems to be a promising drug against HIV infection, but knowledge about its clinical efficacy is scanty.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01977617
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  • 3
    Electronic Resource
    Electronic Resource
    Changes in the profession (1994)
    Springer
    Pharmacy world & science 16 (1994), S. 333-333 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02178562
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  • 4
    Electronic Resource
    Electronic Resource
    Etoposide phosphate, the water soluble prodrug of etoposide (1996)
    Springer
    Pharmacy world & science 18 (1996), S. 163-170 
    Details
    ISSN: 1573-739X
    Keywords: Alkaline phosphatase ; Etoposide ; Etoposide phosphate ; Mechanism of action ; Pharmaceutical formulation ; Pharmacokinetics ; Prodrug
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Etoposide (Vepesid) is a widely used drug in a variety of neoplasms. To improve the pharmaceutical characteristics of etoposide, etooside phosphate (Etopophos, Bristol-Myers Squibb) has been developed as a prodrug. Etoposide phosphate is the phosphate ester derivative of etoposide, in comparison to the parent compound, etoposide phosphate is highly soluble in water and can be readily formulated for intravencus uso resulting in higher ctinical application. This paper presents information on the pharmaceutical properties and the current status of etoposide phosphate in clinical triafs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00820727
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  • 5
    Electronic Resource
    Electronic Resource
    Regional infusion of fluoropyrimidines for hepatic metastases of colorectal cancer (1988)
    Springer
    Pharmacy world & science 10 (1988), S. 69-75 
    Details
    ISSN: 1573-739X
    Keywords: 5-Fluorouracil ; Floxuridine ; Infusions, intra-arterial ; Liver ; Neoplasm metastasis ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Recent reports on regional chemotherapy for hepatic metastases of colorectal origin are reviewed. Because of reported side effects and lack of evidence for its superiority over conventional intravenous administration, intra-arterial administration of fluoropyrimidines cannot be advised for routine use, but should be restricted to centres participating in clinical trials on this subject.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01962681
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetic aspects during continuous ambulatory peritoneal dialysis: a literature review (1984)
    Springer
    Pharmacy world & science 6 (1984), S. 229-236 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Since its introduction some years ago continuous ambulatory peritoneal dialysis (CAPD) has proved to be a valuable alternative to haemodialysis in the treatment of uraemia. Factors contributing to the transport of solutes through the peritoneal membrane are discussed and the literature concerning the pharmacokinetic aspects of CAPD is reviewed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954550
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  • 7
    Electronic Resource
    Electronic Resource
    Preparation and stability testing of a hydrogel for topical analgesia (1995)
    Springer
    Pharmacy world & science 17 (1995), S. 214-217 
    Details
    ISSN: 1573-739X
    Keywords: Anesthetics, local ; Chemistry, analytical ; Drug compounding ; Drug stability ; Eutectic mixture ; Hydrogels ; Menthol ; Prilocaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract With the commercial availability of a cream (EMLA®) containing a eutectic mixture of local anaesthetics, 2.5% (w/w) lidocaine and 2.5% (w/w) prilocaine, effective topical anaesthesia of the intact skin is possible without the need for subcutaneous injections or exposure to high concentrations of local anaesthetics. In our hospital a topical anaesthetic product was designed for the same purpose. The home-made product contains a eutectic mixture of a local anaesthetic (5% w/w) and l-menthol (1% w/w). Prilocaine was used as the local anaesthetic because it is known for its safety and its well investigated analgesic effects. The eutectic mixture of prilocaine and l-menthol was mixed with a carbopol hydrogel (1% w/w). Preliminary testing of this anaesthetic hydrogel in our hospital has yielded satisfactory results. The anaesthetic hydrogel was found to be stable after at least 3 months' storage at ambient temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870614
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  • 8
    Electronic Resource
    Electronic Resource
    Reply (1996)
    Springer
    Pharmacy world & science 18 (1996), S. 85-85 
    Details
    ISSN: 1573-739X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00579713
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  • 9
    Electronic Resource
    Electronic Resource
    A simple high pressure liquid chromatographic method for the determination of fluorouracil to monitor patients on regional infusion for hepatic metastases (1990)
    Springer
    Pharmacy world & science 12 (1990), S. 154-157 
    Details
    ISSN: 1573-739X
    Keywords: Administration, continuous intraportal ; Chromatography, high pressure liquid ; Fluorouracil
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A rapid and sensitive high pressure liquid chromatographic method has been developed for the routine monitoring in serum of the antineoplastic agent fluorouracil, during continuous intraportal administration. Serum spiked with internal standard, bromouracil, was gently shaken for 10 min with ethylacetate at an acidic pH. The evaporated extract was dissolved in the mobile phase containing potassium phosphate buffer. Assays were performed at ambient temperature on a Chrompack LiChrosorb RP 18 column (2×100×3.0 mm) equipped with a guard column. The retention time of fluorouracil was 2–6 min. The calibration curve was linear from 25 to 2,000 ng/ml. The coefficient of variation was ≤1.6% for within-run precision and ≤2.9% for day-to-day precision. The mean recovery of fluorouracil was 57%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01970157
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