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  • 1
    Electronic Resource
    Electronic Resource
    Nucleotide sequence of phenylalanine transfer RNA from Schizosaccharomyces pombe: implications for transfer RNA recognition by yeast phenylalanyl-tRNA synthetase (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 1622-1628 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00602a007
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  • 2
    Electronic Resource
    Electronic Resource
    The distance-dependence of the fission yeastade6-M26 marker effect in two-factor crosses (1996)
    Springer
    Current genetics 29 (1996), S. 530-536 
    Details
    ISSN: 1432-0983
    Keywords: Conversion ; M26 hotspot ; Recombination ; Schizosaccharomyces pombe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Random spore analysis of crosses between a strain bearing theade6-M26 hotspot mutation and strains bearing otherade6 mutations was performed. Recombinant prototroph frequencies increase with increasing distance fromM26 for mutations both 5′ and 3′ ofM26. Maximum prototroph frequencies are obtained for mutations lying more than 700 nucleotides down-stream fromM26. Similar results are obtained for crosses with theade6-M375 control mutation, but the prototroph frequencies are lower. The factor of stimulation of recombination byM26 as compared to theM375 control (M26 marker effect) also displays distance-dependence. These results are discussed in the context of the mechanism ofM26 recombination, as well as in relation to recombination initiation, hybrid DNA formation, and mismatch repair atade6.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02426957
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  • 3
    Electronic Resource
    Electronic Resource
    Genetic nomenclature and gene list of the fission yeast Schizosaccharomyces pombe (1987)
    Springer
    Current genetics 11 (1987), S. 575-589 
    Details
    ISSN: 1432-0983
    Keywords: Schizosaccharomyces pombe ; Genetic nomenclature ; Gene list
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The nomenclature rules for the genetics of the fission yeast Schizosaccharomyces pombe have been fixed for the first time, after discussion among scientists working with this organism. Conventions are proposed for the naming of genes and alleles that are obtained by classical means or by reverse genetics. In addition a list has been compiled of 460 known genes of S. pombe. It includes genes defined both by classical mutation analysis and by molecular cloning. 270 genes have been assigned either to one of the three nuclear chromosomes or the mitochondrial genome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00393919
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  • 4
    Electronic Resource
    Electronic Resource
    Recombination between dispersed serine tRNA genes in Schizosaccharomyces pombe (1982)
    [s.l.] : Nature Publishing Group
    Nature 300 (1982), S. 225-231 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] During meiosis in fission yeast, transfer of genetic information occurs between tRNA genes of related sequence even when they are located on different chromosomes. This process of intergenic conversion has been analysed with the help of nonsense suppressors derived from three unlinked serine tRNA ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/300225a0
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  • 5
    Electronic Resource
    Electronic Resource
    Involvement of nucleotide-excision repair in msh2 pms1 -independent mismatch repair (1999)
    [s.l.] : Nature America Inc.
    Nature genetics 21 (1999), S. 314-317 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nucleotide-excision repair (NER) and mismatch repair (MMR) are prominent examples of highly conserved DNA repair systems which recognize and replace damaged and/or mispaired nucleotides in DNA. In humans, inheritable defects in components of the NER system are associated with severe diseases ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/6838
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  • 6
    Electronic Resource
    Electronic Resource
    Microtubule-driven nuclear movements and linear elements as meiosis-specific characteristics of the fission yeasts Schizosaccharomyces versatilis and Schizosaccharomyces pombe (1995)
    Springer
    Chromosoma 104 (1995), S. 203-214 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Meiotic prophase in Schizosaccharomyces pombe is characterized by striking nuclear movements and the formation of linear elements along chromosomes instead of tripartite synaptonemal complexes. We analysed the organization of nuclei and microtubules in cells of fission yeasts undergoing sexual differentiation. S. japonicus var. versatilis and S. pombe cells were studied in parallel, taking advantage of the better cytology in S. versatilis. During conjugation, microtubules were directed towards the mating projection. These microtubules seem to lead the haploid nuclei together in the zygote by interaction with the spindle pole bodies at the nuclear periphery. After karyogamy, arrays of microtubules emanating from the spindle pole body of the diploid nucleus extended to both cell poles. The same differentiated microtubule configuration was elaborated upon induction of azygotic meiosis in S. pombe. The cyclic movements of the elongated nuclei between the cell poles is reflected by a dynamic and coordinated shortening and lengthening of the two microtubule arrays. When the nucleus was at a cell end, one array was short while the other bridged the whole cell length. Experiments with inhibitors showed that microtubules are required for karyogamy and for the elongated shape and movement of nuclei during meiotic prophase. In both fission yeasts the SPBs and nucleoli are at the leading ends of the moving nuclei. Astral and cytoplasmic microtubules were also prominent during meiotic divisions and sporulation. We further show that in S. versatilis the linear elements formed during meiotic prophase are similar to those in S. pombe. Tripartite synaptonemal complexes were never detected. Taken together, these findings suggest that S. pombe and S. versatilis share basic characteristics in the organization of microtubules and the structure and behaviour of nuclei during their meiotic cell cycle. The prominent differentiations of microtubules and nuclei may be involved in the pairing, recombination, and segregation of meiotic chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352185
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  • 7
    Electronic Resource
    Electronic Resource
    Microtubule-driven nuclear movements and linear elements as meiosis-specific characteristics of the fission yeasts Schizosaccharomyces versatilis and Schizosaccharomyces pombe (1995)
    Springer
    Chromosoma 104 (1995), S. 203-214 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Meiotic prophase in Schizosaccharomyces pombe is characterized by striking nuclear movements and the formation of linear elements along chromosomes instead of tripartite synaptonemal complexes. We analysed the organization of nuclei and microtubules in cells of fission yeasts undergoing sexual differentiation. S. japonicus var. versatilis and S. pombe cells were studied in parallel, taking advantage of the better cytology in S. versatilis. During conjugation, microtubules were directed towards the mating projection. These microtubules seem to lead the haploid nuclei together in the zygote by interaction with the spindle pole bodies at the nuclear periphery. After karyogamy, arrays of microtubules emanating from the spindle pole body of the diploid nucleus extended to both cell poles. The same differentiated microtubule configuration was elaborated upon induction of azygotic meiosis in S. pombe. The cyclic movements of the elongated nuclei between the cell poles is reflected by a dynamic and coordinated shortening and lengthening of the two microtubule arrays. When the nucleus was at a cell end, one array was short while the other bridged the whole cell length. Experiments with inhibitors showed that microtubules are required for karyogamy and for the elongated shape and movement of nuclei during meiotic prophase. In both fission yeasts the SPBs and nucleoli are at the leading ends of the moving nuclei. Astral and cytoplasmic microtubules were also prominent during meiotic divisions and sporulation. We further show that in S. versatilis the linear elements formed during meiotic prophase are similar to those in S. pombe. Tripartite synaptonemal complexes were never detected. Taken together, these findings suggest that S. pombe and S. versatilis share basic characteristics in the organization of microtubules and the structure and behaviour of nuclei during their meiotic cell cycle. The prominent differentiations of microtubules and nuclei may be involved in the pairing, recombination, and segregation of meiotic chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00352185
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  • 8
    Electronic Resource
    Electronic Resource
    Synchronized meiosis and recombination in fission yeast: observations with pat1-114 diploid cells (1991)
    Springer
    Current genetics 19 (1991), S. 445-451 
    Details
    ISSN: 1432-0983
    Keywords: Synchronized meiosis ; Schizosaccharomyces pombe ; Meiotic recombination ; pat1-114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The mutation pat1-114 has been used to synchronize meiosis in the fission yeast Schizosaccharomyces pombe. We have investigated several aspects of such synchronized meiotic cultures. In both pat1-114 and pat1 + diploids, meiotic landmark events are initiated at the same time after meiosis induction, but synchrony is much more pronounced in the pat1-114-driven meiosis. Commitment to recombination and to meiosis have been timed at 2 h after meiotic induction. Due to a seven-fold reduction of intragenic recombination frequency in the ade6 region of pat1-114 diploids, physical analysis of recombination has not been possible. We have distinguished three factors that influence intragenic recombination frequencies: temperature, azygotic versus zygotic meiosis, and the nature of the pat1 allele. Differences and similarities in the timing of meiotic landmarks in S. cerevisiae and S. pombe are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00312735
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  • 9
    Electronic Resource
    Electronic Resource
    Observations on integrative transformation in Schizosaccharomyces pombe (1988)
    Springer
    Molecular genetics and genomics 215 (1988), S. 87-93 
    Details
    ISSN: 1617-4623
    Keywords: Schizosaccharomyces pombe ; Integrative transformation ; Homologous integration ; Illegitimate recombination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Three different Schizosaccharomyces pombe strains have been transformed with a circular or linearized non-ars plasmid carrying the ura4 + gene as a selectable marker. The first strain shows full homology between the genomic ura4-294 gene (point mutation) and the marker gene on the plasmid. The second strain carries a 600 bp deletion (ura4-D6) that decreases homology between plasmid and chromosome. No homology remains in the third strain which has a complete deletion of the ura4 gene on the chromosome (ura4-D18). When sequence homology exists between transforming DNA and the chromosomal ura4 region, gene conversion is strongly preferred over integration of the circular plasmid. Reduction of the length of homology leads to a decrease of transformation frequencies, and homology dependent as well as a minority of homology independent integrations are observed. In the complete absence of homology two rate types of transformants are encountered: either the circular plasmid replicates autonomously, although it is devoid of an ars sequence, or alternatively the plasmid integrates into the genome at various positions. Transformation with plasmid cut within the coding region of ura4 can lead to tandemly arranged multiple integrations, when no homology exists between the free ends and the chromosome. The integrations occur at the ura4 locus, when homology is retained between plasmid and chromosome, and at various sites in the genome of the strain with a complete deletion of the ura4 gene. The results suggest that homology dependent events (conversion, integration) are strongly preferred in transformation of S. pombe with non-ars plasmids. In addition low frequency integration by illegitimate recombination is observed. Linearized plasmid can be ligated in vivo to form monomers or multimers in the absence of homology between the free plasmid ends and the chromosomal genome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331308
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  • 10
    Electronic Resource
    Electronic Resource
    Mitotic recombination between dispersed but related rRNA genes of Schizosaccharomyces pombe generates a reciprocal translocation (1986)
    Springer
    Molecular genetics and genomics 202 (1986), S. 394-402 
    Details
    ISSN: 1617-4623
    Keywords: Mitotic recombination ; Schizosaccharomyces pombe
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Recombination between dispersed yet related serine tRNA genes of Schizosaccharomyces pombe does occur during mitosis but it is approximately three orders of magnitude less frequent than in meiosis. Two mitotic events have been studied in detail. In the first, a sequence of at least 18 nucleotides has been transferred from the donor sup3 gene on the right arm of chromosome I to the related acceptor gene sup12 on the left arm of the same chromosome, thereby leading to the simultaneous change of 8 bp in the acceptor gene. This event must be explained in terms of recombination rather than mutation. It is assumed that it represents mitotic gene conversion, although it was not possible to demonstrate that the donor gene had emerged unchanged from the event. The second case reflects an interaction between sup9 on chromosome III and sup3 on chromosome I. Genetic and physical analysis allows this event to be described as mitotic gene conversion associated with crossingover. The result of this event is a reciprocal translocation. No further chromosomal aberrations were found among an additional 700 potential intergenic convertants tested. Thus intergenic conversion is much less frequently associated with crossingover than allelic conversion. However, the rare intergenic conversion events associated with crossingover provide a molecular mechanism for chromosomal rearrangements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00333268
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