Publication Date:
2016-03-26
Description:
Article The Wnt/β-catenin signalling pathway contributes to radio resistance in intestinal stem cells but the underlying mechanism is currently unknown. In this study, the authors demonstrate that LIG4, a DNA ligase involved in the DNA repair process, is a direct target of β-catenin and it specifically mediates non-homologous end joining repair in colorectal cancer cells. Nature Communications doi: 10.1038/ncomms10994 Authors: Sohee Jun, Youn-Sang Jung, Han Na Suh, Wenqi Wang, Moon Jong Kim, Young Sun Oh, Esther M. Lien, Xi Shen, Yoshihisa Matsumoto, Pierre D. McCrea, Lei Li, Junjie Chen, Jae-Il Park
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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