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  • 1
    Keywords: Biotechnology. ; Biomedical engineering. ; Biotechnology. ; Biomedical Engineering and Bioengineering.
    Description / Table of Contents: 1.Confocal laser scanning microscopy and fluorescence correlation methods for evaluation of molecular interactions -- 2.Number and Brightness Imaging: visualization of protein oligomerization state in living cell -- 3.Single-molecule analysis on the coupling of molecular state and reaction kinetics -- 4.Imaging lipid rafts in the plasma membrane using novel probe and super-resolution microscopy -- 5.Multiplex Immunohistochemistry (IHC) -- 6.Micro-endoscopy for live small animal fluorescent imaging -- 7.Immuno-gold techniques -- 8.Correlative Light and Electron Microscopy for Nanoparticle-Cell Interaction -- 9.Diagnostic and Therapeutic Nanomedicine -- 10.Semiconductor nanocrystals for biological imaging and fluorescence spectroscopy -- 11.DNA/RNA fluorescence imaging by synthetic nucleic acids -- Section II: Label-free techniques and advanced tomographic imaging -- 12.“Magnetic resonance imaging for preclinical study -- 13.Holotomography techniques for 3D label-free imaging of live cells and tissues -- 14.Dynamic-contrast optical imaging techniques -- 15.Emerging biological and clinical applications of photoacoustic tomography -- Section III: Potential (synergic) biotechnologies to be joined with imaging techniques -- 16.Generation of genetically-engineered mouse models using CRISPR-Cas system -- 17.Highly efficient generation of cell lines stably expressing genes of interest via Cre recombinase mediated knock-in method in mouse embryonic stem (ES) cells and its application for microscopic imaging techniques -- 18.Mass spectrometry based metabolomics in translational research -- 19.Application of mass spectrometry in drug metabolism and pharmacokinetics for drug development -- 20.Discovery and Application of Chemical Probes for Translational Research -- 21.Regeneration of skin cells by mesenchymal stem cell-derived exosomes.
    Abstract: This book is a wide-ranging guide to advanced imaging techniques and related methods with important applications in translational research or convergence science as progress is made toward a new era in integrative healthcare. Conventional and advanced microscopic imaging techniques, including both non-fluorescent (i.e., label-free) and fluorescent methods, have to date provided researchers with specific and quantitative information about molecules, cells, and tissues. Now, however, the different imaging techniques can be correlated with each other and multimodal methods developed to simultaneously obtain diverse and complementary information. In addition, the latest advanced imaging techniques can be integrated with non-imaging techniques such as mass spectroscopic methods, genome editing, organic/inorganic probe synthesis, nanomedicine, and drug discovery. The book will be of high value for researchers in the biological and biomedical sciences or convergence science who need to use these multidisciplinary and integrated techniques or are involved in developing new analytical methods focused on convergence science. .
    Type of Medium: Online Resource
    Pages: VI, 564 p. 191 illus., 161 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9789813360648
    Series Statement: Advances in Experimental Medicine and Biology, 1310
    DDC: 660.6
    Language: English
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  • 2
    Call number: AWI G3-05-0090
    Type of Medium: Monograph available for loan
    Pages: S. 131 - 145
    Series Statement: Journal of Geological Society Korea 32,2
    Language: English
    Branch Library: AWI Library
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  • 3
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Biochemistry. ; Renewable energy sources. ; Environmental engineering. ; Biotechnology. ; Bioremediation. ; Sustainability. ; Biochemistry. ; Renewable Energy. ; Environmental Engineering/Biotechnology. ; Sustainability.
    Description / Table of Contents: Chapter 1. Introduction -- Chapter 2. Fractionation strategies -- Chapter 3. Biochemical conversion of cellulose -- Chapter 4. Biochemical conversion of hemicellulose -- Chapter 5. Biochemical conversion of lignin -- Chapter 6. Thermochemical conversion of cellulose and hemicellulose -- Chapter 7. Thermochemical conversion of lignin -- Chapter 8. Material application of lignin -- Chapter 9. TEA for evaluating biorefinery strategies.
    Abstract: This book focuses on the technologies developed for the conversion of all three biomass components, i.e. cellulose, hemicellulose and lignin, and their constituents, to fuels and high-value products. Both biochemical and thermochemical approaches are reviewed. Additionally, the developed technologies are described in detail and their potential applications as well as their commercial status are discussed. The early attempts to produce fuel ethanol from lignocellulosic biomass feedstock focused solely on the biological conversion of cellulose because the only organism that had been used successfully for commercial production of ethanol, i.e. Saccharomyces cerevisiae, could only ferment glucose, which was obtained from the hydrolysis of cellulose. Hemicellulose and lignin were considered as wastes in these processes and were normally removed in pretreatment processes to enhance enzymatic hydrolysis of the remaining cellulose. However, this approach was not economically feasible and as a result, the biorefinery concept was developed. In a biorefinery, in addition to ethanol, various higher-value products are produced from hemicellulose and lignin, which were previously not considered. Consequently, technologies were developed for the fractionation of biomass and conversion of hemicellulose and lignin to fuels and high-value products to improve the economic feasibility. Written and edited by a team of investigators with many years of experience in biomass processing research and development, this book is an informative resource for postgraduate students and researchers interested in biorefinery and biofuel technologies both in academia- and commercial laboratories.
    Type of Medium: Online Resource
    Pages: IX, 245 p. 43 illus., 19 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031058356
    DDC: 572
    Language: English
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  • 4
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: 1. History of sialic acids, gangliosides and GM3 -- 2. Synthesis of GM3 -- 3. Molecular localization of GM3 in cells -- 4. Basic function of GM3 as an interacting molecule -- 5. GD3 mimetics with a neurite forming capacity -- 6. GM3 as a pathogenic infection receptor -- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis -- 8. GM3 has an anti-tumor capacity -- 9. GM3 suppresses tumor angiogenesis -- 10. Interaction between EGFR and GM3 -- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling -- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase -- 13. VEGFR-GM3 interaction in angiogenesis -- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis -- 15. GM3 interacts with TGFβ Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation -- 16. Galectin-1 promotes tumor growth and escapes immune surveillance -- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing -- 18. GM3, caveolin-1 and insulin receptor in insulin resistance -- 19. GM3 suppresses arthritis -- 20. GM3 protects cochlear hair cells and hearing from corti degeneration -- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1 -- 22. GM3 in leukemic cells into terminal differentiation -- 23. α2,3-Sialyllactose (3SL) or α2,6-sialyllactose (6SL) of GM3 glycan in innate immunity. .
    Abstract: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
    Type of Medium: Online Resource
    Pages: VII, 138 p. 32 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811556524
    DDC: 572.8
    Language: English
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  • 5
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Neurosciences. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry. ; Neuroscience. ; Immunology. ; Physiology. ; Neuropsychology. ; Psychiatry.
    Description / Table of Contents: 1.How Immune-inflammatory processes link neurodegenerative and psychiatric disorders -- 2.Gut-Microbiota-Brain Axis: pathophysiological mechanism in neuropsychiatric disorders -- 3.Microbiome- induced autoimmunity and novel therapeutic intervention -- 4.The key role of microlia and circulating monocytes in etipathology neuropsychiatric disorders -- 5.Neuro-immuno-epigenetics of prenatal psychological stress -- 6.C-reactive protein (CRP): a potent inflammation biomarker in psychiatric disorders -- 7.Neuroinflammation, neurognesis and neuroprotection in schizophrenia -- 8.Autoimmue psycosis: concept, clinical manifestation and management -- 9.Stress, autonomic nervous system and kynurenine pathway in major depression -- 10.Brain-gut-microbiome axis in major depression : novel therapeutic approach -- 11.Glial-Neuronal Interaction in Synapses: A Possible Mechanism of the Pathophysiology of Bipolar Disorder -- 12.Neuroimmaging of inflammation in depression and anxiety disorders -- 13.Neuroinflammation and immune-kynureinine pathway in anxiety disorders -- 14.Inflammatory-mediated responses in development of neurogeneartive diseases -- 15.The connection between gut-brain axis and PTSD -- 16.Eating disorders : Gut microbiota-immune-brain interactions -- 17.Sleep-immune crosstalk and sleep disorders -- 18.Obsessive-compulsive disorder: immuno-inflammatory disorder? -- 19.Cytokine, neuroinflammation and neurodeneration in Alzheimer’s disease -- 20.Molecular imaging of neuroinflammation in Alzheimer's disease and MCI -- 21.The role of N-Methyl-D-Aspartate Receptor Neurotransmission and mictobiota in Alzheimer’s disease -- 22.Neuroglial activation and neuroinflammation in the brain of patients with autism -- 23.Suicide and inflammation -- 24.Anti-inflammatory effect of Traditional Chinese Medicine on the concept of Mind-body interface -- 25.Anti-inflammatory therapy as a promising target in neupsychiatric disorders.
    Abstract: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
    Type of Medium: Online Resource
    Pages: XVII, 554 p. 28 illus., 20 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9789811973765
    Series Statement: Advances in Experimental Medicine and Biology, 1411
    DDC: 612.8
    Language: English
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  • 6
    Keywords: Biotechnology. ; Lipids. ; Food science. ; Biotechnology. ; Lipidology. ; Food Science.
    Description / Table of Contents: Chapter 1. Vegetable Oils and Animal Fats: Sources, Properties and Recovery -- Chapter 2. Exotic Oil: Sources, Properties and Recovery -- Chapter 3. Seed Oil: Sources, Properties and Recovery -- Chapter 4. Vegetable Oil Refining -- Chapter 5. MINOR COMPONENTS IN EDIBLE OIL -- Chapter 6. Blending, Hydrogenation, Fractionation and Interesterification Processing -- Chapter 7. Ionic Liquid as a Green Solvent for Lipid Processing -- Chapter 8. Diacylglycerol Oil: Health Benefits, Synthesis and Applications -- Chapter 9. Medium-and Long-Chain Triacylglycerol: Production, Health Effects and Applications -- Chapter 10. Enzymatic synthesis of human milk fat substitutes -- Chapter 11. Cocoa Butter Alternatives for Food Applications -- Chapter 12. Oleogel: Production and Application -- Chapter 13. Characterization of Nanoemulsions: The Way Forward -- Chapter 14. Processing Contaminants In Edible Oil -- Chapter 15. Enzymatic Biodiesel Production from Low-Quality Waste Oils and Non-edible Oils: Current Status and Future Prospects -- Chapter 16. Sustainability and Traceability in the Malaysian Oil Palm Industry -- Chapter 17. Adulteration in Oils and Fats Industry.
    Abstract: This book is written by international experts with both academic and industrial credentials. It presents for the first time, a collection of up-­to-­date scientific advances in the area of edible fats and oils technology, over a span of 10 years from 2009 to the year 2019. The book covers the existing and recent advanced techniques adopted in the edible fats and oils research and touches on the processing and modification, to the traceability and sustainability issues of fats and oils. Some recent technologies like supercritical carbon dioxide, microwave, ultrasound, and enzymatic‐ assisted processes, ionic liquid, enzymatic processes, biosensor and membrane technology are presented in the book. The book aims to provide the technologists and researchers in research, development and operations in the edible fats and oils industries with critical and readily accessible information on the recent advances in the field. The book is divided into three broad sections- Fats and Oils Chemistry and Processing, Fats and Oils Modification and Health Implications, and Fats and Oils Safety, Social, Environmental and Economic Impacts. It is an extremely comprehensive and valuable resource, which serves as an essential reference for students and lipid scientists from academia or industry.
    Type of Medium: Online Resource
    Pages: X, 492 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9789811651137
    DDC: 660.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Singapore :Springer Nature Singapore :
    Keywords: Molecular genetics. ; Cancer. ; Genetics. ; Biochemistry. ; Biological transport. ; Cell membranes. ; Molecular Genetics. ; Cancer Biology. ; Genetics and Genomics. ; Biochemistry. ; Membrane Trafficking.
    Description / Table of Contents: Preface: Carbohydrates- the third life chain -- 1. Glycosylation -- 2. N-Glycan and O-glycan glycosylation in eukaryotes -- 3. Sialyltransferase, sialylation and sulfoylation -- 4. Congenital disorders of glycosylation (CDG) of N-glycoprotein -- 5. Neuraminic acids/sialic acids (N-acetyl- and N-glycolylneuraminic acid) -- 6. Biosynthesis of sialic acid -- 7. Neu5Gc (N-glycolylneuraminic acid) -- 8. Gangliosides -- 9. Gangliosides and tumor-associated ganglioside (TAG) modulate receptor-tyrosine kinases (RTKs) -- 10. Sialic acids and TAGs of tumor cells to escape immunesurveillance and immuneediting -- 11. Tumor characteristics in tumor related carbohydrates.
    Abstract: This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.
    Type of Medium: Online Resource
    Pages: XVI, 214 p. 57 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811558153
    DDC: 572.8
    Language: English
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  • 8
    Keywords: Cancer. ; Nanomedicine. ; Drug delivery systems. ; Nanotechnology. ; Cancer Nanotechnology. ; Drug Delivery. ; Nanotechnology. ; Nanomedicine and Nanotoxicology.
    Description / Table of Contents: Foreword -- Preface -- Introduction to active smart nanomaterials for biomedical applications -- Cancer cell sensing and therapy using affinity tag-conjugated gold nanoparticles -- Gold nanoparticles enlighten the future of cancer theranostics -- Recent advances in hydrogels smart drug delivery systems -- Carbon-based nanomaterials for biomedical applications -- A new era of cancer treatment: carbon nanotubes as drug delivery tools -- pH- and ion-sensitive materials for control drug delivery -- Thermo-responsive polymers and their application as smart biomaterias -- Redox-responsive polymers and their application in drug delivery systems -- Recent strategies to explore the biomedical applications of nanocellulose -- Tissue engineering using cellulose nanofibrils as Scaffold material -- Use of solidlipid nanoparticles to improve the oral bioavailability of poor soluble drugs -- Applications of dendrimers in drug delivery systems -- Liposomes for drug delivery: progress and problems -- Cubosome nanoparticles for enhanced delivery of anticancer drug -- Layer-by-Layer assemblies for cancer diagnosis and treatment -- Polymeric micelles for drug delivery -- Role of plant-based materials/gums in developing drug delivery systems -- Ethosomes: A novel tool for drug delivery through the skin -- Niosomes as nanoparticular drug carriers: fundamentals and recent applications -- Graphene oxide nanosheets used in photothermal therapy -- Metal doped carbon dots used in bio-imaging and cancer therapy -- Bibliography -- Glossary -- Index.
    Abstract: With the start of 2020, the wrath of pandemic challenged the scientific community to develop more advanced drug delivery approaches for biomedical applications, endowing conventional drugs with additional therapeutic benefits and minimum side effects. Although significant advancements have been done in the field of drug delivery, there is a need to focus towards strategizing novel and improved drug delivery systems that should be convenient and cost-effective to the patients, and simultaneously they should also provide financial benefits to pharmaceutical companies. Controlled drug delivery technology offers ample opportunities and scope for improvising the therapeutic efficacy of drugs via optimizing the drug release rate and time. For this endeavour, smart nanomaterials have served as remarkable candidates for biomedical applications, owing to their ground-breaking properties and design. The development of such nanomaterials requires a broad knowledge related to their physio-chemical properties, molecular structure, mechanisms by which the nanomaterials interact with the cells, and methods by which drugs are released at the site of action. This knowledge must also be allied with the knowledge of signaling crosstalk mechanisms that are modulated by the nanomaterial-drugs composite. It can be anticipated that these emerging drug delivery technologies can facilitate the world to successfully encounter such pandemic outbursts in the future in a cost-effective and time-effective manner. The chapters in this book deal with the advanced technologies and approaches that can benefit advanced students, researchers, and industry experts in developing smart and intelligent nanomaterials for future biomedical applications, and development, manufacturing, and commercialization for controlled and targeted drug delivery.
    Type of Medium: Online Resource
    Pages: XIII, 600 p. 131 illus., 122 illus. in color. , online resource.
    Edition: 1st ed. 2021.
    ISBN: 9783030842628
    Series Statement: Nanotechnology in the Life Sciences,
    DDC: 616.994
    Language: English
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  • 9
    Keywords: Physical geography. ; Climatology. ; Water. ; Hydrology. ; Engineering geology. ; Oceanography. ; Earth System Sciences. ; Climate Sciences. ; Water. ; Geoengineering. ; Ocean Sciences.
    Description / Table of Contents: 1. A 14-year Multi-sites and High-frequency Monitoring of Salinity in the Tidal Garonne River (S-W France) Reveals Marked Inter-annual Variability In Marine Intrusion -- 2. Study on Salinity Intrusion and Mixing Types in a Conceptual Estuary using 3-D Hydrodynamic Simulation: Effects of Length, Width, Depth, and Bathymetry -- 3. Response of Salinity Intrusion to the Fictitious Blockade of the North Branch in the Yangtze Estuary, China -- 4. Influence of the Salinity Intrusion on Island Water Source Safety: A Case Study of the Chongming Island, China -- 5. Law of salt tide intrusion of the Qiantang Estuary and its numerical simulation -- 6. Seasonal salinity variations in a coastal wetland induced by complex interactions between sea, river and evapoconcentration processes -- 7. Water Quality Mitigation Scenarios for Burullus Coastal Lake, Egypt -- 8. Research on the Setting Condition of Tailrace Surge Chambers for Seawater Pumped-storage Power Stations with Long Tailrace Tunnels.
    Abstract: This book is a collection of extended papers based on presentations given during the ICEC 2018 conference, held in Caen, France, in August 2018. It explores both the limitations and advantages of current models, and highlights the latest developments concerning new numerical schemes, high-performance computing, multi-physics and multi-scale methods, and better interaction with field or scale model data. Accordingly, it addresses the interests of practitioners, stakeholders, researchers, and engineers active in this field. .
    Type of Medium: Online Resource
    Pages: XX, 843 p. 494 illus., 402 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811520815
    Series Statement: Springer Water,
    DDC: 550
    Language: English
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  • 10
    Keywords: Environment. ; Sustainability. ; Renewable energy sources. ; Environmental management. ; Environmental Sciences. ; Sustainability. ; Renewable Energy. ; Environmental Management.
    Abstract: This book consists of selected and peer-reviewed papers of 2022 5th International Conference on Green Energy and Environment Engineering (CGEEE 2022), held in Jeju Island, Korea during July 28-30, 2022. CGEEE 2022 provides a forum for researchers and practitioners in the field of green energy and environment engineering to share ideas, designs, and experiments results. Various topics are covered in this book, such as carbon capture and storage, solar energy, biomass, biofuel, geothermal, sustainable cities, energy savings for vehicular technology, solid waste management, waste minimization, water treatment and reclamation, environmental restoration, and ecological engineering. This book will be beneficial to researchers, educators, practitioners, and policymakers working in the related fields.
    Type of Medium: Online Resource
    Pages: X, 168 p. 102 illus., 67 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031278037
    Series Statement: Springer Proceedings in Earth and Environmental Sciences,
    DDC: 333.7
    Language: English
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