ISSN:
1573-4927
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Peptide γCB-3 is the indicator of the presence and activity of nonallelic structural genes for the human γ-chain. An equivalent peptide has been isolated from the HbF of the marmoset (Saguinus fuscicollis), the rhesus monkey (Macaca mulatta), the orangutan (Pongo pygmaeus), and the gorilla (Gorilla gorilla gorilla). The sequence of γCB-3 from the marmoset and the rhesus monkey, although different from that of human γCB-3, gives no evidence of heterogeneity of the HbF. However, the HbF of the rhesus monkey is itself heterogeneous, and there probably is a difference in another part of the γ-chain. The γCB-3 peptide of the orangutan is definitely heterogeneous: the heterogeneity is in position 135, however, rather than in position 136 as in human γCB-3. The gorilla has the same type of heterogeneity at position 136 as does the human, but the proportions of the two types of chains might differ in the two species.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00485708
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