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  • 1
    ISSN: 0730-2312
    Keywords: cell proliferation ; tumor progression ; EGF receptor ; ErbB ; HER1 ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is an activating ligand for the EGF receptor (HER1/ErbB1) and the high-affinity receptor for diphtheria toxin (DT) in its transmembrane form (proHB-EGF). HB-EGF was immunolocalized within human benign and malignant prostatic tissues, using monospecific antibodies directed against the mature protein and against the cytoplasmic domain of proHB-EGF. Prostate carcinoma cells, normal glandular epithelial cells, undifferentiated fibroblasts, and inflammatory cells were not decorated by the anti-HB-EGF antibodies; however, interstitial and vascular smooth muscle cells were highly reactive, indicating that the smooth muscle compartments are the major sites of synthesis and localization of HB-EGF within the prostate. In marked contrast to prostatic epithelium, proHB-EGF was immunolocalized to seminal vesicle epithelium, indicating differential regulation of HB-EGF synthesis within various epithelia of the reproductive tract. HB-EGF was not overexpressed in this series of cancer tissues, in comparison to the benign tissues. In experiments with LNCaP human prostate carcinoma cells, HB-EGF was similar in potency to epidermal growth factor (EGF) in stimulating cell growth. Exogenous HB-EGF and EGF each activated HER1 and HER3 receptor tyrosine kinases and induced tyrosine phosphorylation of cellular proteins to a similar extent. LNCaP cells expressed detectable but low levels of HB-EGF mRNA; however, proHB-EGF was detected at the cell surface indirectly by demonstration of specific sensitivity to DT. HB-EGF is the first HER1 ligand to be identified predominantly as a smooth muscle cell product in the human prostate. Further, the observation that HB-EGF is similar to EGF in mitogenic potency for human prostate carcinoma cells suggests that it may be one of the hypothesized stromal mediators of prostate cancer growth. J. Cell. Biochem. 68:328-338, 1998. © 1998 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 2
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    Düsseldorf: Hans-Böckler-Stiftung
    Publication Date: 2016-04-21
    Description: Der Chemieriese DuPont veröffentlicht seit Jahren außerordentlich geringe Unfallzahlen. Was steckt hinter diesen statistischen Werten? Ein besonders effizientes Arbeitsschutzsystem? Abweichende und damit nicht vergleichbare Bewertungsmaßstäbe? Diese Studie versucht, einen Blick hinter die Kulissen zu tun. Es werden Konzept und Praxis des Arbeitsschutzes bei DuPont dargestellt, ebenso eine Analyse der Erfolgsfaktoren, die Möglichkeiten zur Mitwirkung seitens der Beschäftigten und die Handlungsmöglichkeiten des Betriebsrates innerhalb dieses Konzeptes. Schließlich wird auch die Frage einer Übertragbarkeit dieses Arbeitsschutzsystems auf Dritte angeschnitten.
    Keywords: ddc:330
    Repository Name: EconStor: OA server of the German National Library of Economics - Leibniz Information Centre for Economics
    Language: German
    Type: doc-type:workingPaper
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  • 3
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Superficial bladder cancer is often treated by removing the cancerous portion of thebladder wall combined with immuno-chemotherapy; in more extreme cases, it is often necessary toremove the entire bladder wall. This diagnosis brings an obvious need for bladder tissue replacementdesigns with a high degree of efficacy. Since bladder cells are accustomed to interacting withextracellular matrix proteins having dimensions on the nanometer scale, this study aimed to designthe next generation of tissue-engineered bladder replacement constructs with nanometer (less than100 nm) surface features. For this purpose, porous and biodegradable PLGA and PU scaffolds weretreated with various concentrations of NaOH or HNO3, respectively, for various periods of time tocreate nanometer surface roughness. Resulting surface properties were characterized using SEM (tovisualize scaffold properties) and BET. Cell experiments conducted on these polymeric scaffoldsprovided evidence of enhanced bladder smooth muscle cell attachment, growth, and elastin/collagenproduction (critical extracellular matrix proteins in the bladder tissue regeneration process) as surfacefeature dimensions were reduced into the nanometer regime. In vivo augmentation surgeries withnano-structured PLGA and PU patches will provide further information regarding total bladdercapacity, anastomotic integrity, burst pressure, epithelialization, muscular ingrowth, andneovascularization. In vitro and in vivo proof of material usefulness and technique would provideurologists with a readily accessible graft for bladder tissue replacement applications
    Type of Medium: Electronic Resource
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