ISSN:
0947-3440
Keywords:
β-Amino alcohols
;
Organophosphorus compounds
;
Methoxyphosphane borane complexes
;
Enantioselective borane reduction
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
New, chiral 1,3,2-oxazaphospholidine-borane complexes 3a-b and 8a-d were synthesized from the β-amino alcohols 1a-b and 6a-d. The borane complexes 3, 8a, 8c, and 8d were allowed to react with different organolithium compounds and afforded the corresponding aminophosphane-borane complexes 4a-c and 9a-g. Acid methanolysis of those complexes led to the formation of the phosphinite-borane complexes 5a-c. This is a further example of the utilization of the industrial waste material (all-R)-2-azabicyclo-[3.3.0]octane-3-carboxylic acid. The catalytic efficiency of the chiral 1,3,2-oxazaphospholidine-borane complexes 3a, 3b, and 8c was examined in the enantioselective borane reduction of some ketones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1995199512298
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