ISSN:
1573-4919
Keywords:
poly(ADP-ribose) glycohydrolase
;
antibody
;
expression
;
ADP-ribose polymer metabolism
;
DNA repair
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract We have recently described the isolation and characterization of bovine cDNA encoding poly(ADP-ribose) glycohydrolase (PARG). We describe here the preparation and characterization of antibodies to PARG. These antibodies have been used to demonstrate the presence of multiple forms of PARG in tissue and cell extracts from bovine, rat, mouse, and insects. Our results indicate that multiple forms of PARG previously reported could result from a single gene. Analysis of PARG in cells in which poly(ADP-ribose) polymerase (PARP) has been genetically inactivated indicates that the cellular content of PARG is regulated independently of PARP.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006912210439
Permalink