Publication Date:
2006-03-04
Description:
Immunity to a plethora of microbes depends on a diverse repertoire of naive lymphocytes and the production of long-lived memory cells. We present evidence here that low clonal abundance in a polyclonal repertoire favors the survival and activation of naive CD4(+) T cells as well as the survival of their memory cell progeny. The inverse relation between clonal frequency and survival suggests that intraclonal competition could help maintain an optimally diverse repertoire of T cells and an optimal environment for the generation of long-lived memory cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hataye, Jason -- Moon, James J -- Khoruts, Alexander -- Reilly, Cavan -- Jenkins, Marc K -- AI27998/AI/NIAID NIH HHS/ -- AI39614/AI/NIAID NIH HHS/ -- F32 AI063793/AI/NIAID NIH HHS/ -- F32 AI063793-01A1/AI/NIAID NIH HHS/ -- T32 CA009138/CA/NCI NIH HHS/ -- T32-AI007313/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2006 Apr 7;312(5770):114-6. Epub 2006 Mar 2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. hata0006@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16513943" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
CD4-Positive T-Lymphocytes/*immunology/physiology
;
Cell Survival
;
Clone Cells/immunology/physiology
;
Half-Life
;
Histocompatibility Antigens Class II/immunology
;
*Immunologic Memory
;
Lymphocyte Activation
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Ovalbumin/immunology
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocyte Subsets/*immunology/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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