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  • 1
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    ^{243}Am neutron-induced fission cross section in the fast neutron energy range (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-04-20
    Description: Author(s): G. Kessedjian, G. Barreau, M. Aïche, B. Jurado, A. Bidaud, S. Czajkowski, D. Dassié, B. Haas, L. Mathieu, L. Tassan-Got, J. N. Wilson, F. -J. Hambsch, S. Oberstedt, I. AlMahamid, J. Floyd, W. Lukens, and D. Shuh The existing evaluations of the 243 Am neutron-induced fission cross section have been questioned by recent measurements performed at the GNEISS facility. In the neutron energy range from 1 to 6 MeV, the GNEISS data present deviations of more than 15 % with respect to the evaluations. In order to solv... [Phys. Rev. C 85, 044613] Published Thu Apr 19, 2012
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Evaluating the impact of pulse oximetry on childhood pneumonia mortality in resource-poor settings (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-12-04
    Description: It is estimated that pneumonia is responsible for 15% of childhood deaths worldwide. Recent research has shown that hypoxia and malnutrition are strong predictors of mortality in children hospitalized for pneumonia. It is estimated that 15% of children under 5 who are hospitalized for pneumonia have hypoxaemia and that around 1.5 million children with severe pneumonia require oxygen treatment each year. We developed a deterministic compartmental model that links the care pathway to disease progression to assess the impact of introducing pulse oximetry as a prognostic tool to distinguish severe from non-severe pneumonia in under-5 year olds across 15 countries with the highest burden worldwide. We estimate that, assuming access to supplemental oxygen, pulse oximetry has the potential to avert up to 148,000 deaths if implemented across the 15 countries. By contrast, integrated management of childhood illness alone has a relatively small impact on mortality owing to its low sensitivity. Pulse oximetry can significantly increase the incidence of correctly treated severe cases as well as reduce the incidence of incorrect treatment with antibiotics. We also found that the combination of pulse oximetry with integrated management of childhood illness is highly cost-effective, with median estimates ranging from US$2.97 to $52.92 per disability-adjusted life year averted in the 15 countries analysed. This combination of substantial burden reduction and favourable cost-effectiveness makes pulse oximetry a promising candidate for improving the prognosis for children with pneumonia in resource-poor settings.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Floyd, Jessica -- Wu, Lindsey -- Hay Burgess, Deborah -- Izadnegahdar, Rasa -- Mukanga, David -- Ghani, Azra C -- Medical Research Council/United Kingdom -- England -- Nature. 2015 Dec 3;528(7580):S53-9. doi: 10.1038/nature16043.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, Norfolk Place, London W2 1PG, UK. ; Department of Immunology and Infection, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. ; The Bill &Melinda Gates Foundation, 500 Fifth Avenue North, Seattle, Washington 98109, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26633766" target="_blank"〉PubMed〈/a〉
    Keywords: Anoxia/complications/diagnosis ; Child ; Cost-Benefit Analysis ; Disease Progression ; Global Health ; Health Resources/*economics ; Humans ; Incidence ; *Oximetry/economics/utilization ; Oxygen/therapeutic use ; Pneumonia/*diagnosis/economics/*mortality/therapy ; Sensitivity and Specificity
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    The UK10K project identifies rare variants in health and disease (2015)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2015-09-15
    Description: The contribution of rare and low-frequency variants to human traits is largely unexplored. Here we describe insights from sequencing whole genomes (low read depth, 7x) or exomes (high read depth, 80x) of nearly 10,000 individuals from population-based and disease collections. In extensively phenotyped cohorts we characterize over 24 million novel sequence variants, generate a highly accurate imputation reference panel and identify novel alleles associated with levels of triglycerides (APOB), adiponectin (ADIPOQ) and low-density lipoprotein cholesterol (LDLR and RGAG1) from single-marker and rare variant aggregation tests. We describe population structure and functional annotation of rare and low-frequency variants, use the data to estimate the benefits of sequencing for association studies, and summarize lessons from disease-specific collections. Finally, we make available an extensive resource, including individual-level genetic and phenotypic data and web-based tools to facilitate the exploration of association results.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773891/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773891/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉UK10K Consortium -- Walter, Klaudia -- Min, Josine L -- Huang, Jie -- Crooks, Lucy -- Memari, Yasin -- McCarthy, Shane -- Perry, John R B -- Xu, ChangJiang -- Futema, Marta -- Lawson, Daniel -- Iotchkova, Valentina -- Schiffels, Stephan -- Hendricks, Audrey E -- Danecek, Petr -- Li, Rui -- Floyd, James -- Wain, Louise V -- Barroso, Ines -- Humphries, Steve E -- Hurles, Matthew E -- Zeggini, Eleftheria -- Barrett, Jeffrey C -- Plagnol, Vincent -- Richards, J Brent -- Greenwood, Celia M T -- Timpson, Nicholas J -- Durbin, Richard -- Soranzo, Nicole -- 091551/Wellcome Trust/United Kingdom -- 095515/Wellcome Trust/United Kingdom -- 095564/Wellcome Trust/United Kingdom -- 098498/Wellcome Trust/United Kingdom -- 100140/Wellcome Trust/United Kingdom -- 104036/Wellcome Trust/United Kingdom -- CZD/16/6/4/Chief Scientist Office/United Kingdom -- MC_UU_12013/3/Medical Research Council/United Kingdom -- RG/10/13/28570/British Heart Foundation/United Kingdom -- WT091310/Wellcome Trust/United Kingdom -- England -- Nature. 2015 Oct 1;526(7571):82-90. doi: 10.1038/nature14962. Epub 2015 Sep 14.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26367797" target="_blank"〉PubMed〈/a〉
    Keywords: Adiponectin/blood ; Alleles ; Cohort Studies ; Disease/*genetics ; Exome/genetics ; Female ; Genetic Predisposition to Disease/genetics ; Genetic Variation/*genetics ; Genetics, Medical ; Genetics, Population ; Genome, Human/*genetics ; Genome-Wide Association Study ; Genomics ; Great Britain ; *Health ; Humans ; Lipid Metabolism/genetics ; Male ; Molecular Sequence Annotation ; Receptors, LDL/genetics ; Reference Standards ; Sequence Analysis, DNA ; Triglycerides/blood
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 4
    Electronic Resource
    Electronic Resource
    Large activation energy barriers to chaperone-peptide complex formation and dissociation (1995)
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 15574-15582 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00047a024
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Gas purification and pressure control system for inert atmosphere boxes (1969)
    s.l. : American Chemical Society
    Analytical chemistry 41 (1969), S. 1708-1709 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60281a003
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  • 6
    Electronic Resource
    Electronic Resource
    PRELIMINARY NOTE ON A NEW SEPARATION OF THORIUM. (1902)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 24 (1902), S. 275-276 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02017a013
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  • 7
    Electronic Resource
    Electronic Resource
    A NEW SEPARATION OF THORIUM FROM CERIUM, LANTHANUM, AND DIDYMIUM, AND ITS APPLICATION TO THE ANALYSIS OF MONAZITE.1 (1902)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 24 (1902), S. 901-917 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02024a001
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  • 8
    Electronic Resource
    Electronic Resource
    The Absorption Spectra of Some Chloro-Substituted Tetracyclones (1951)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 73 (1951), S. 228-229 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja01145a078
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  • 9
    Electronic Resource
    Electronic Resource
    Evidence for fault weakness and fluid flow within an active low-angle normal fault (2001)
    [s.l.] : Macmillian Magazines Ltd.
    Nature 411 (2001), S. 779-783 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Determining the composition and physical properties of shallow-dipping, active normal faults (〉dips 〈 35° with respect to the horizontal) is important for understanding how such faults slip under low resolved shear stress and accommodate significant extension of the crust and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35081040
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  • 10
    Electronic Resource
    Electronic Resource
    Physical Injury Risks Associated with Drinking Water Arsenic Treatment (2002)
    Oxford, UK : Blackwell Publishing, Inc
    Risk analysis 22 (2002), S. 0 
    Details
    ISSN: 1539-6924
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Notes: We estimated the number of transportation deaths that would be associated with water treatment in Albuquerque to meet the EPA's recently proposed revisions of the Maximum Contaminant Level (MCL) for arsenic. Vehicle mileage was estimated for ion exchange, activated alumina, and iron coagulation/microfiltration water treatment processes to meet an MCL of 0.020 mg/L, 0.010 mg/L, 0.005 mg/L, and 0.003 mg/L. Local crash, injury, and death rates per million vehicle miles were used to estimate the number of injuries and deaths. Depending on the water treatment options chosen, we estimate that meeting an arsenic MCL of 0.005 mg/L will result in 143 to 237 crashes, 58 to 98 injuries, and 0.6 to 2.6 deaths in Albuquerque over a 70-year period, resulting in 26 to 113 years of life lost. The anticipated health benefits for Albuquerque residents from a 0.005 mg/L arsenic MCL, estimated using either a multistage Weibull or Poisson model, ranged from 3 to 80 arsenic-related bladder and lung cancer deaths prevented over a 70-year period, adding between 43 and 1,123 years of life. Whether a revised arsenic MCL increases or reduces overall loss of life in Albuquerque depends on the accuracy of EPA's cancer risk assessment. If the multistage Weibull model accurately estimates the benefits, the years of life added is comparable or lower than the anticipated years lost due to transportation associated with the delivery of chemicals, disposal of treatment waste, and operation of the water treatment system. Coagulation/microfiltration treatment will result in substantially fewer transportation deaths than either ion exchange or activated alumina.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/0272-4332.00032
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