ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    R & D management 35 (2005), S. 0 
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: This paper presents and discusses the contribution of ‘mentoring’ relationships to organisational learning and knowledge creation in the early stages of research and development (R&D) projects. Our study considers the characteristics of a scientific leader, the nature of the context he creates, and how dialogue contributes to scientific breakthrough. Our study is unusual in as much as research on knowledge creation has developed separately, yet in parallel, with that of mentoring. It is rare to combine these disciplines and yet our research shows there is much to learn from examining the two as a process.We conducted our research at TECHNO, a high-tech-based European company producing advanced equipment dedicated to particles acceleration. Interviews were carried out in 2002–2003 with the founder of the company, the head of the R&D and engineering department, and team members involved in the low energy cyclotron project.Our exploratory research enabled us to identify differences in actors' perceptions about the nature and characteristics of these relationships. Our study also suggests that not all sets of relationships can tolerate the degree of intensity provided by the ‘mentor’. TECHNO has other ‘mentors’ who do not manage to generate the same creative context. Complementary mentoring styles based on premises and process reflection allow to support and enhance ‘upper levels’ learning by junior team members. We examine the nature of the leaders as mentors and catalysts within the learning process and briefly discuss implications for setting up and maintaining learning teams.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK and Boston, USA : Blackwell Publishers Ltd
    R & D management 28 (1998), S. 0 
    ISSN: 1467-9310
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Notes: In this article a set of determinants of organisational learning and result appropriation are identified and then tested on a sample of Research and Development (R&D) consortia. The literature review and an exploratory case study highlight the main factors which favour learning and the appropriation of knowledge. The case study observes the organisational learning processes at work in three R&D partnerships entered into by a European high technology firm. Six hypotheses are formulated. They pertain to the link between the firm's learning and exploitation capabilities. The hypotheses relate to (1) trust between partners, (2) R&D integration in the firm, (3) the access to adequate complementary assets, (4) the member's involvement and motivation in the cooperative process, (5) its own experience in R&D, and (6) the number of partners in the consortium. These hypotheses are tested on a sample of 317 R&D consortia in the European EUREKA initiative. The results show that a firm's internal organisation and the level of trust between partners influence learning and result appropriation. However, the determinants vary according to the kind of outcome (tangible knowledge, new products/processes, improved products/processes, intangible knowledge). With the knowledge that alliances are increasingly becoming a necessity for firms involved in technology, a better understanding of how to benefit from R&D partnerships can only improve firms’ competitiveness in the future.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2013-06-03
    Description: Background: Epidermal Growth Factor (EGF) plays an important function in the regulation of cell growth, proliferation, and differentiation by binding to its receptor (EGFR) and providing cancer cells with increased survival responsiveness. Signal transduction carried out by EGF has been extensively studied at both transcriptional and post-transcriptional levels. Little is known about the involvement of microRNAs (miRNAs) in the EGF signaling pathway. miRNAs have emerged as major players in the complex networks of gene regulation, and cancer miRNA expression studies have evidenced a direct involvement of miRNAs in cancer progression. Results: In this study, we have used an integrative high content analysis approach to identify the specific miRNAs implicated in EGF signaling in HeLa cells as potential mediators of cancer mediated functions. We have used microarray and deep-sequencing technologies in order to obtain a global view of the EGF miRNA transcriptome with a robust experimental cross-validation. By applying a procedure based on Rankprod tests, we have delimited a solid set of EGF-regulated miRNAs. After validating regulated miRNAs by reverse transcription quantitative PCR, we have derived protein networks and biological functions from the predicted targets of the regulated miRNAs to gain insight into the potential role of miRNAs in EGF-treated cells. In addition, we have analyzed sequence heterogeneity due to editing relative to the reference sequence (isomiRs) among regulated miRNAs. Conclusions: We propose that the use of global genomic miRNA cross-validation derived from high throughput technologies can be used to generate more reliable datasets inferring more robust networks of co-regulated predicted miRNA target genes.
    Electronic ISSN: 1471-2164
    Topics: Biology
    Published by BioMed Central
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2015-11-11
    Print ISSN: 0167-4544
    Electronic ISSN: 1573-0697
    Topics: Philosophy , Economics
    Published by Springer
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...