Regular and relayed heteronuclear correlations
Single 2D NMR experiment
Analytical Chemistry and Spectroscopy
Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
In order to achieve a better suppression of signals arising from protons non-bonded to the considered heteronucleus, two (π/4) proton pulses are used in the HMQC sequence: one, at the very beginning, replaces the classical (π/2) pulse and the other is at the end of the sequence. In addition, a spin-lock purging period improves the elimination process. This novel sequence is shown to provide the conventional heteronuclear correlations and, in addition, relayed homonuclear (proton-proton) correlations. A simple methodology capable of sorting out both types of correlations is proposed. However, this procedure entails a sensitivity loss by a factor of two.
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