Wiley InterScience Backfile Collection 1832-2000
Chemistry and Pharmacology
The synthesis of nine macrocyclic polyamines 2-10 containing pyridine units is described. These compounds are 22- (9), 24- (2-4,6,8,10), or 26- (5, 7) membered hexaaza (2,3,9,10) or octaaza (4-7) macrocycles in which one to four pyridine units are incorporated. Compounds 3,4,9, and 10 are homoditopic ligands, whereas 2 and 5 are heteroditopic and 6-8 multitopic receptors. Compounds 2-10 are potential ligands for metal cations as well as, in their protonated forms, for anions. Protonated macrocycles 2-10 are also potential catalysts for the hydrolysis of nucleotides and polyphosphates.
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