ISSN:
0021-8995
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
,
Physics
Notes:
The preparation of stable syndiotacticity-rich poly(vinyl alcohol) (s-PVA) hydrogels is easier in comparison with that of the atactic poly(vinyl alcohol) (a-PVA) hydrogels. The drug release with use of s-PVA hydrogels containing indomethacin of 1.5 mg/mL buffer, solution was studied under several conditions: at the gelation temperatures of 20-30°C, the release temperatures of 27-47°C, and pHs of phosphate buffer solutions of 6.6-7.4, for the gels with the concentrations of PVA of 3-8% using the degree of polymerization of 2170-4380. Indomethacin has been released spending 14 h. The diffusion exponents were 0.45-0.50, corresponding to Fickian diffusion. © 1995 John Wiley & Sons, Inc.
Additional Material:
10 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/app.1995.070580815
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