ISSN:
0170-2041
Keywords:
1,3-Asymmetric induction
;
Butyrolactones
;
Halolactonization
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Iodolactonization of 2-alkoxy- and 2-hydroxy-4-alkenoic acids 3a-d under kinetic control gives mixtures of cis- and trans-lactones 6a-d and 7a-d with cis-selectivity up to 5.5:1.0. The bromolactonization of carboxamides 4 a, 4 c, and 5 c shows moderate 1,3-asymmetric induction, favoring the trans-lactones 9 with a selectivity of up to 2.5:1.0.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199019900161
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