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  • 1
    Publication Date: 2022-03-29
    Description: Space radiation is one of the main concerns in planning long‐term human space missions. There are two main types of hazardous radiation: solar energetic particles (SEP) and galactic cosmic rays (GCR). The intensity and evolution of both depends on solar activity. GCR activity is most enhanced during solar minimum and lowest during solar maximum. The reduction of GCRs is alagging behind solar activity only by 6–12 month. SEP probability and intensity are maximized during solar maximum and are minimized during solar minimum. In this study, we combine models of the particle environment arising due to SEP and GCR with Monte Carlo simulations of radiation propagation inside a spacecraft and phantom. We include 28 fully ionized GCR elements from hydrogen to nickel and consider protons and nine ion species to model the SEP irradiation. Our calculations demonstrate that the optimal time for a flight to Mars would be launching the mission at solar maximum, and that the flight duration should not exceed approximately 4 years.
    Description: Plain Language Summary: Space particle radiation is one of the main concerns in planning long‐term human space missions. There are two main types of hazardous particle radiation: (a) solar energetic particles (SEP) originating from the Sun and (b) galactic cosmic rays (GCR) that come from the distant galaxies in space. Fluxes in particles of solar origin maximize during solar maximum when particles originating from the distant galaxies are more efficiently deflected from the solar system during times when the sun is active. Our calculations clearly demonstrate that the best time for launching a human space flight to Mars is during the solar maximum, as it is possible to shield from SEP particles. Our simulations show that an increase in shielding creates an increase in secondary radiation produced by the most energetic GCR, which results in a higher dose, introducing a limit to a mission duration. We estimate that a potential mission to Mars should not exceed approximately 4 years. This study shows that while space radiation imposes strict limitations and presents technological difficulties for the human mission to Mars, such a mission is still viable.
    Description: Key Points: Space missions to Mars should be scheduled to be launched during solar max. Optimal spacecraft shielding is ~30 g/cm2, which allows long‐duration flights of ~4 years. Increase of shielding thickness beyond ~30 g/cm2 results in dose increase.
    Keywords: ddc:629.416
    Language: English
    Type: doc-type:article
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  • 2
    Publication Date: 2021-10-04
    Description: Space radiation is one of the main concerns in planning long-term human space missions. There are two main types of hazardous radiation: Solar Energetic Particles (SEP) and Galactic Cosmic Rays (GCR). The intensity and evolution of both depends on solar activity. GCR activity is most enhanced during solar minimum and lowest during solar maximum. SEP probability and intensity are maximized during solar maximum and are minimized during solar minimum. In this study, we combine models of the particle environment arising due to SEP and GCR with Monte-Carlo simulations of radiation propagation inside a spacecraft and phantom. We include 28 fully ionized GCR elements from hydrogen to nickel and consider protons and nine ion species to model the SEP irradiation. Our calculations demonstrate that the optimal time for a flight to Mars is during solar maximum, and that the flight duration should not exceed approximately 4 years.
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 1983-1984 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 13 (1980), S. 1194-1198 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 95 (1973), S. 5822-5823 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 31 (1959), S. 1934-1940 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 49 (1979), S. 57-74 
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Self-exchange of chloride and sulfate in dog and cat red cells has been measured under equilibrium conditions. The rates of efflux for these anions are approximately twofold higher in dog compared to cat red blood cells. Although the rates differ, the anion exchange systems of these two red cell types exhibit many common properties. The dependence of35SO4 efflux on the intracellular SO4 concentration, the pH dependence and the inhibition of35SO4 efflux by Cl and SITS are almost identical in dog and cat red cells. Nystatin treatment was used to study the dependence of36Cl efflux on internal Cl. Chloride efflux exhibits saturation in both cell types with dog red cells possessing a higherV max andK 1/2 than cat red cells. The number of anion transport sites was estimated by extrapolation to the number of molecules of dihydro DIDS (H2DIDS, where DIDS is 4,4′-diisothiocyano-2,2′ stilbene-disulfonic acid) which were bound at 100% inhibition of transport. The results indicate that either the turnover numbers for anion transport differ in dog, cat, and human red cells or that there is heterogeneity in the function of the membrane components which bind H2DIDS.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 91 (1961), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 185 (1960), S. 186-187 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A hæmolysate of completely lysed human erythrocytes wTas made approximately isotonic with plasma by the addition of 3 M salt solution (5 parts potassium chloride and 1 part sodium chloride) to give final concentrations of 150 mM potassium chloride and 30 mM sodium chloride. The ghosts were ...
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 181 (1958), S. 706-707 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have combined streptomycin, neomycin, viomycin and strepto-thrycin with carboxyl, sulphonie or phosphorylated high molecular compounds and studied the changes in their pharmacological properties. In one series of experiments the question of the colloidal versus the crystalloid behaviour of these ...
    Type of Medium: Electronic Resource
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