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  • 1
    Monograph available for loan
    Monograph available for loan
    Soil carbon dynamics : an integrated methodology (2009)
    Cambridge [u.a.] : Cambridge Univ. Press
    Details Availability
    Call number: M 12.0112
    Description / Table of Contents: Carbon stored in soils represents the largest terrestrial carbon pool and factors affecting this will be vital in the understanding of future atmospheric CO2 concentrations. This book provides an integrated view on measuring and modelling soil carbon dynamics
    Type of Medium: Monograph available for loan
    Pages: XI, 286 S. , graph. Darst.
    ISBN: 9780521865616
    Classification:
    Geography and Geomorphology
    Note: Erscheinungsjahr in Vorlageform:2009
    Location: Upper compact magazine
    Branch Library: GFZ Library
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  • 2
    Electronic Resource
    Electronic Resource
    PRE5 and PRE6, the Last Missing Genes Encoding 20S Proteasome Subunits from Yeast? Indication for a Set of 14 Different Subunits in the Eukaryotic Proteasome Core (1994)
    s.l. : American Chemical Society
    Biochemistry 33 (1994), S. 12229-12237 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00206a028
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  • 3
    Electronic Resource
    Electronic Resource
    Characterization of the guanosine 5'-triphosphate 3'-diphosphate and guanosine 5'-diphosphate 3'-diphosphate degradation reaction catalyzed by a specific pyrophosphorylase from Escherichia coli (1978)
    s.l. : American Chemical Society
    Biochemistry 17 (1978), S. 5368-5372 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00618a007
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in carotenoid biosynthesis caused by variations of growth conditions in cultures of Rhodopseudomonas acidophila strain 7050 (1983)
    Springer
    Archives of microbiology 134 (1983), S. 217-221 
    Details
    ISSN: 1432-072X
    Keywords: Rhodopseudomonas acidophila ; Carotenoids ; Glucosidic carotenoids ; Rhodopinal synthesis ; Light intensities
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Rhodopseudomonas acidophila strain 7050 was grown at 2000 and 400 lx with pyruvate, lactate, succinate, fumarate, and DL-malate as substrates. The cells were analyzed for their pigmentation and especially for their carotenoid composition. The data showed that low light promoted synthesis of rhodopinal and its glucoside with all substrates tested. But with pyruvate, succinate and malate the low light effect was intensified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407761
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  • 5
    Electronic Resource
    Electronic Resource
    Quantitative determination by HPLC of urinary 6β-hydroxycortisol, an indicator of enzyme induction by rifampicin and antiepileptic drugs (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 63-71 
    Details
    ISSN: 1432-1041
    Keywords: 6beta-hydroxycortisol ; rifampicin ; cortisol metabolism ; high performance ; liquid chromatography ; urine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A method for determination of 6β-hydroxycortisol in urine by means of high performance liquid chromatography is described. After extraction of 10–30 ml aliquots of urine with ethylacetate, separation is accomplished on a silica gel column (30 cm, Lichrosorb Si 100) with a special two-phase four-component eluent of methylene chloride, n-hexane, ethanol and water. Complete separation of α- andβ-isomers requires 15 to 20 min. For routine determinations precolumn cleaning by backflush permits injections of samples at minimum time intervals. For quantitative determinations, each injection should contain at least 0.05–0.5 µg of 6β-hydroxycortisol, depending on the detector employed. The mean excretion rate in healthy male adults (26–40 years) was 273 µg/day (SD=74.5; n=12). In patients on long term mono-therapy with rifampicin, 6β-hydroxycortisol excretion had risen fourfold (1166 µg/d; SEM=248; n=7), paralleling the known enzyme-inducing effect of rifampicin. The relatively smaller increase to 498 µg/d observed in patients receiving triple therapy with rifampicin, isoniazid and ethambutol points to possible inhibition by isoniazid. The greatest stimulation of 6β-hydroxycortisol excretion (2352 µg/d) was found in patients receiving antiepileptic therapy (phenytoin and/or carbamazepine and other drugs). The HPLC technique for 6β-hydroxycortisol proved to be a tool routinely applicable to non-invasive evaluation of drug metabolizing enzyme activity in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00644969
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  • 6
    Electronic Resource
    Electronic Resource
    Kinetics of hexobarbital and dipyrone in critical care patients receiving high-dose pentobarbital (1987)
    Springer
    European journal of clinical pharmacology 32 (1987), S. 273-277 
    Details
    ISSN: 1432-1041
    Keywords: pentobarbital ; hexobarbital ; dipyrone ; intensive care ; D-glucaric acid ; pharmacokinetics ; drug interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of pentobarbital treatment in a mean dose of 30 mg/kg/day on the clearance of hexobarbital (Evipan) and dipyrone (Novalgin) has been evaluated in critical care patients receiving a large number of drugs as comedication. Eleven patients treated with pentobarbital showed a hexobarbital half-life of 2.79 h and a total plasma clearance of 9.80 ml·min−1·kg−1 as compared to 10 patients without pentobarbital administration in whom there was a significantly longer half life (6.92 h) and lower clearance (2.97 ml·min−1·kg−1). The kinetics of hexobarbital were correlated with the urinary excretion of D-glucaric acid, a non-invasive parameter of drug metabolising activity. In 10 patients on pentobarbital, the total plasma clearance of N-4-methylaminoantipyrine, the active form of dipyrone, did not differ from that in 8 patients not receiving pentobarbital. As drug kinetics show great variability in these patients, it is difficult to discriminate enzyme induction from other mechanisms, for example competitive inhibition or changes in volume of distribution. In the presence of pentobarbital, however, induction of drug metabolising enzymes should be considered as a possible reason for the higher clearance of hexobarbital.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00607575
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetic interaction between cyclosporin and diltiazem (1990)
    Springer
    European journal of clinical pharmacology 38 (1990), S. 237-242 
    Details
    ISSN: 1432-1041
    Keywords: cyclosporin A ; diltiazem ; pharmacokinetics ; kidney transplantation ; drug metabolism ; cytochrome P-450 ; drug interactions ; human liver microsomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Previous reports have indicated that administration of the calcium antagonist diltiazem results in major changes in the pharmacokinetics of cyclosporin A (CyA). A new clinical trial was undertaken in 22 renal transplant patients receiving a constant dose of cyclosporin to further explore this interaction. Coadministration of diltiazem for one week produced an increase in the blood concentration of CyA and its metabolites 17 and 18 in almost all patients, but no increase in CyA metabolites 1 and 21. The mean whole blood CyA trough level determined by HPLC rose from 117 ng·ml−1 to 170 ng·ml−1 after one week on diltiazem, and the mean trough level of metabolite 17 rose similarly from 184 ng·ml−1 before to 336 ng·ml−1. Based on experiments with microsomes from human liver the effect of diltiazem was due to noncompetitve inhibition of CyA-metabolism by diltiazem, and the increased concentration of metabolite 17 might have been due to stronger inhibition of its secondary metabolism steps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315023
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  • 8
    Electronic Resource
    Electronic Resource
    The kinetics of metamizol and its metabolites in critical-care patients with acute renal dysfunction (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 445-450 
    Details
    ISSN: 1432-1041
    Keywords: Metamizol ; Acute renal failure ; Sepsis ; intensive care patients ; drug metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the clearance of monomethylaminoantipyrine (MMAAP), the pharmacologically active form of metamizol, in 46 patients in surgical intensive care with different degrees of renal dysfunction. In 23 patients without any renal impairment, mean clearance was 2.8 ml·min−1·kg−1. Twentyone patients with acute renal impairment had a significantly reduced clearance of MMAAP (0.83 ml·min−1·kg−1). There was also reduced clearance in four patients with septic shock (1.0 ml·min−1·kg−1). Kinetics of the metabolites of MMAAP (N-formylaminoantipyrine (FAAP), aminoantipyrine (AAP), and its secondary product N-acetylaminoantipyrine (AcAAP)) were calculated. FAAP and AcAAP showed delayed invasion, which can be explained by reduced hepatic metabolic activity. The product of N-demethylation, AAP, was not significantly altered. The delayed elimination of monomethylaminoantipyrine can be explained by reduced hepatic function in parallel with acute renal failure due to disturbed cardiovascular function caused by septic shock. This may also lead to disturbed hepatic macro- and microperfusion associated with altered oxygen supply and oxygen consumption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315516
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  • 9
    Electronic Resource
    Electronic Resource
    Nucleotide sequence of the clustered genes for apocytochrome b6 and subunit 4 of the cytochrome b/f complex in the spinach plastid chromosome (1984)
    Springer
    Current genetics 8 (1984), S. 543-549 
    Details
    ISSN: 1432-0983
    Keywords: Plastid DNA ; Cytochrome b6 gene ; Amino acid sequence ; Hydropathy ; Thylakoid membrane ; Transcript modification ; Evolution ; Spinach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A 2.4 kilobase-pair segment of the spinach plastid chromosome carrying the genes for apocytochrome b6 and subunit 4 of the thylakoid membrane cytochrome b/f complex has been analysed by DNA sequencing and Northern blot analysis. The nucleotide sequence reveals two uninterrupted open reading frames of 211 and 139 triplets coding for two hydrophobic proteins of 23.7 kd (cytochrome b6) and 15.2 kd (subunit 4). The genes are located on the same strand and are separated from each other by 1018 untranslated base pairs. They map adjacent to the gene for the P680 chlorophyll α apoprotein of the photosystem II reaction center. The three genes appear to be under common transcriptional control and the transcripts post-transcriptionally modified. The deduced amino acid sequences of cytochrome b6 and subunit 4 both exhibit significant homology with published sequences from mitochondrial b cytochromes (42 kd) suggesting that these functionally equivalent polypeptides in photosynthetic and respiratory electron transport chains arose monophyletically.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410442
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  • 10
    Electronic Resource
    Electronic Resource
    EFFECT OF FAT AND TEXTURED SOY PROTEIN CONTENT ON CONSUMER ACCEPTANCE OF GROUND BEEF (1975)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 40 (1975), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1975.tb01085.x
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