ISSN:
1432-0703
Source:
Springer Online Journal Archives 1860-2000
Topics:
Energy, Environment Protection, Nuclear Power Engineering
,
Medicine
Notes:
Abstract. The objective of this study was to further characterize the developmental toxicity of mono-n-butyl phthalate (MBuP), which is one of the major metabolites of n-butyl benzyl phthalate (BBP) and di-n-butyl phthalate (DBP). Pregnant rats were given MBuP by gastric intubation at a dose of 500, 625 or 750 mg/kg on days 7–9, days 10–12, or days 13–15 of pregnancy. A significantly increased incidence of postimplantation loss was noted in pregnant rats given MBuP on days 7–9 and days 10–12 at doses of 625 mg/kg and above and on days 13–15 at doses of 500 mg/kg and above. No evidence of teratogenicity was found when MBuP was given on days 10–12 of pregnancy. A significantly increased incidence of fetuses with external malformations was found after treatment with MBuP on days 7–9 and days 13–15 at doses of 625 and 750 mg/kg. A significantly increased incidence of fetuses with skeletal malformations was observed after treatment with MBuP on days 7–9 at doses of 500 mg/kg and above and on days 13–15 at doses of 625 mg/kg and above. Deformity of the cervical vertebrae was predominantly observed following treatment with MBuP on days 7–9. Cleft palate and fusion of the sternebrae were exclusively found following treatment with MBuP on days 13–15. It could be concluded that the manifestation of deviant development induced by MBuP varies with the developmental stage at the time of administration.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00212362
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