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  • 1
    Publication Date: 2017-04-04
    Description: We use a kinematic GPS and laser range findersurvey of a 200 m-long section of the Muliwai a Pele lava channel (Mauna Ulu, Kilauea) to examine the construction processes and flow dynamics responsible for the channel– levee structure. The levees comprise three packages. The basal package comprises an 80–150 m wide ′a′a flow in which a ~2 m deep and ~11 m wide channel became centred. This is capped by a second package of thin (〈45 cm thick) sheets of pahoehoe extending no more than 50 m from the channel. The upper-most package comprises localised ′a′a overflows. The channel itself contains two blockages located 130 m apart and composed of levee chunks veneered with overflow lava. The channel was emplaced over 50 h, spanning 30 May–2 June, 1974, with the flow front arriving at our section (4.4 km from the vent) 8 h after the eruption began. The basal ′a′a flow thickness yields effusion rates of 35 m3 s−1 for the opening phase, with the initial flow advancing across the mapped section at ~10 m/min. Short-lived overflows of fluid pahoehoe then built the levee cap, increasing the apparent channel depth to 4.8 m. There were at least six pulses at 90–420 m3 s−1, causing overflow of limited extent lasting no more than 5 min. Brim-full flow conditions were thus extremely shortlived. During a dominant period of below-bank flow, flow depth was ~2 m with an effusion rate of ~35 m3 s−1, consistent with the mean output rate (obtained from the total flow bulk volume) of 23–54 m3 s−1. During pulses, levee chunks were plucked and floated down channel to form blockages. In a final low effusion rate phase, lava ponded behind the lower blockage to form a syn-channel pond that fed ′a′a overflow. After the end of the eruption the roofed-over pond continued to drain through the lower blockage, causing the roof to founder. Drainage emplaced inflated flows on the channel floor below the lower blockage for a further ~10 h. The complex processes involved in levee–channel construction of this short-lived case show that care must be taken when using channel dimensions to infer flow dynamics. In our case, the full channel depth is not exposed. Instead the channel floor morphology reflects late stage pond filling and drainage rather than true channel-contained flow. Components of the compound levee relate to different flow regimes operating at different times during the eruption and associated with different effusion rates, flow dynamics and time scales. For example, although high effusion rate, brim-full flow was maintained for a small fraction of the channel lifetime, it emplaced a pile of pahoehoe overflow units that account for 60% of the total levee height. We show how time-varying volume flux is an important parameter in controlling channel construction dynamics. Because the complex history of lava delivery to a channel system is recorded by the final channel morphology, time-varying flow dynamics can be determined from the channel morphology. Developing methods for quantifying detailed flux histories for effusive events from the evidence in outcrop is therefore highly valuable. We here achieve this by using highresolution spatial data for a channel system at Kilauea. This study not only indicates those physical and dynamic characteristics that are typical for basaltic lava flows on Hawaiian volcanoes, but also a methodology that can be widely applied to effusive basaltic eruptions.
    Description: In press
    Description: on line first
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: reserved
    Keywords: Lava channel ; Levees ; Effusion rates ; Flow dynamics ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 2
    Publication Date: 2017-04-04
    Description: We use a kinematic GPS and laser range finder survey of a 200 m-long section of the Muliwai a Pele lava channel (Mauna Ulu, Kilauea) to examine the construction processes and flow dynamics responsible for the channel–levee structure. The levees comprise three packages. The basal package comprises an 80–150 m wide ′a′a flow in which a ∼2 m deep and ∼11 m wide channel became centred. This is capped by a second package of thin (〈45 cm thick) sheets of pahoehoe extending no more than 50 m from the channel. The upper-most package comprises localised ′a′a overflows. The channel itself contains two blockages located 130 m apart and composed of levee chunks veneered with overflow lava. The channel was emplaced over 50 h, spanning 30 May–2 June, 1974, with the flow front arriving at our section (4.4 km from the vent) 8 h after the eruption began. The basal ′a′a flow thickness yields effusion rates of 35 m3 s−1 for the opening phase, with the initial flow advancing across the mapped section at ∼10 m/min. Short-lived overflows of fluid pahoehoe then built the levee cap, increasing the apparent channel depth to 4.8 m. There were at least six pulses at 90–420 m3 s−1, causing overflow of limited extent lasting no more than 5 min. Brim-full flow conditions were thus extremely short-lived. During a dominant period of below-bank flow, flow depth was ∼2 m with an effusion rate of ∼35 m3 s−1, consistent with the mean output rate (obtained from the total flow bulk volume) of 23–54 m3 s−1. During pulses, levee chunks were plucked and floated down channel to form blockages. In a final low effusion rate phase, lava ponded behind the lower blockage to form a syn-channel pond that fed ′a′a overflow. After the end of the eruption the roofed-over pond continued to drain through the lower blockage, causing the roof to founder. Drainage emplaced inflated flows on the channel floor below the lower blockage for a further ∼10 h. The complex processes involved in levee–channel construction of this short-lived case show that care must be taken when using channel dimensions to infer flow dynamics. In our case, the full channel depth is not exposed. Instead the channel floor morphology reflects late stage pond filling and drainage rather than true channel-contained flow. Components of the compound levee relate to different flow regimes operating at different times during the eruption and associated with different effusion rates, flow dynamics and time scales. For example, although high effusion rate, brim-full flow was maintained for a small fraction of the channel lifetime, it emplaced a pile of pahoehoe overflow units that account for 60% of the total levee height. We show how time-varying volume flux is an important parameter in controlling channel construction dynamics. Because the complex history of lava delivery to a channel system is recorded by the final channel morphology, time-varying flow dynamics can be determined from the channel morphology. Developing methods for quantifying detailed flux histories for effusive events from the evidence in outcrop is therefore highly valuable. We here achieve this by using high-resolution spatial data for a channel system at Kilauea. This study not only indicates those physical and dynamic characteristics that are typical for basaltic lava flows on Hawaiian volcanoes, but also a methodology that can be widely applied to effusive basaltic eruptions.
    Description: Published
    Description: 459-474
    Description: 1.5. TTC - Sorveglianza dell'attività eruttiva dei vulcani
    Description: 1.10. TTC - Telerilevamento
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: JCR Journal
    Description: reserved
    Keywords: Lava channel ; Levees ; Effusion rates ; Flow dynamics ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 4
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 43 (1921), S. 2218-2223 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 45 (1923), S. 757-762 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 16 (1894), S. 587-597 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1041
    Keywords: tiamenidine ; rebound hypertension ; plasma noradrenaline ; metanephrines ; urinary catecholamines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A limitation of clonidine therapy is the syndrome of rebound hypertension and sympathetic overactivity after withdrawal. Ten patients, four male, six female, aged 28–64 years, with essential hypertension, were treated for one year with an imidazoline derivative, tiamenidine. Blood pressure fell from an average of 178/108 mm Hg pretreatment to 152/86 mm Hg after 1 year. Tiamenidine was then withdrawn in hospital, replaced by identical placebo under single blind conditions and observations made over 96 h. The study was interrupted in five patients (4 patients within 36 h) because blood pressure rose to greater than 30 mm Hg (systolic) or greater than 20 mm Hg (diastolic) above pretreatment values. For the group, blood pressure was maximal at 194/112 mm Hg, 18 h post withdrawal, significantly higher than pretreatment (p〈0.005). Headache, tremor, flushing and insomnia were noted. Saliva production rose 100% at 24 h. Plasma noradrenaline rose within 24 h with an accompanying rise in urinary metanephrine and catecholamine excretion. Tiamenidine appears to share with other imidazolines rebound cardiovascular and autonomic effects following abrupt withdrawal.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 27 (1984), S. 209-215 
    ISSN: 1432-1041
    Keywords: propranolol ; hepatic drug disposition ; rat liver perfusion ; pharmacokinetics in man ; heart rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Studies were conducted to determine the mechanism whereby ethanol alters the hepatic disposition of propranolol. In eight isolated perfused rat livers, ethanol ( $$\bar x$$ =40.1 mmol/l diminished the clearance of dl-propranolol (1.93±0.43 to 1.24±0.22 ml/min/g liver, p〈0.05); increased its t1/2 (12.8±1.5 to 20.7±3.25 min, p〈0.01); and decreased the proportion metabolized (68.7±4.7% to 34.3±10.3%, p〈0.01). These results suggest that ethanol could substantially increase the oral bioavailability of propranolol in humans. However, in normal human volunteers administered 80 mg of propranolol orally, alone, or preceded and followed by ethanol to maintain breath ethanol concentrations of 800–1000 mg/l, increases in propranolol AUC were smaller than anticipated. Seven subjects had increases in free propranolol AUC0–8h (32%, range: 12–61%) (p〈0.05), while total propranolol AUC0–8h increased by a mean 22% (range: −4–+49%). Propranolol free fraction varied with time and was higher after ethanol ( $$\bar x$$ =0.090 vs 0.084) (p〈0.077). The extent of the propranolol-induced slowing of heart rate was not influenced by ethanol (mean decrease from baseline of 13 bpm at peak propranolol effect vs 9 bpm without ethanol); mean heart rates following propranolol with ethanol were higher at all times (mean of 7.5 bpm) (p〈0.001) than after propranolol alone. Ethanol inhibits the hepatic oxidative metabolism of propranolol in vitro; however, any effect on heart rate of higher concentrations of propranolol induced by ethanol in humans is off-set by the cardio-acceleratory effect of ethanol.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 16 (1979), S. 75-80 
    ISSN: 1432-1041
    Keywords: methyldopa ; hypotension ; tricyclic antidepressants ; drug interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.
    Type of Medium: Electronic Resource
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