ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
On the Chemistry of 5-Amino-2-phenyl-1,2,3-thiadiazolium SaltsTreatment of the title compounds 1 with pyridine yield the phenylhydrazones of the 1,2,4-thiadiazol-3,5-diyl-glyoxylic acid derivatives 4. The amides 4a, b can also be obtained by reaction of the phenylhydrazono cyanacetoamides 3a, b with sulphur in the presence of pyridine. Nitriles react with 1 to form the phenylhydrazones of the 1,2,4-thiadiazol-5-yl-glyoxylic acid derivatives 6. Reduction of 6a yields the 1,2,4-thiadiazol-5-yl-glycine derivative 7. Depending on its condition the reaction of 1c with benzoyl acetonitrile yield either the 1,2,4-thiadiazole or the 4-amino-thiazole derivative (6i or 8). From 1a and ethyl acetoacetate the phenylhydrazone of the thiazol-2-yl-glyoxylic acid derivative 9 arises which can be reduced to yield the thiazol-2-yl-glycine derivative 10. The addition of 1 onto isothiocyanates in the presence of pyridine yields the substituted N-(1,2,3-thiadiazol-5-ylidene)-thioureas 12a, b. Carboxylic acids react with 1 in the presence of pyridine to form the 5-Acylimino-1,2,3-Δ3-thiadiazolines 13.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19863280512
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